Systemic hypertension after cardiac transplantation: Effect of cyclosporine on the renin-angiotensin-aldosterone system

Bellet, M; Cabrol, C; Sassano, P; Léger, Philippe; Corvol, Pierre; Ménard, J

doi:10.1016/0002-9149(85)90406-0

Cited by 136 publications

(50 citation statements)

References 17 publications

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“…Contrary to studies in the rat and dog, for example, numerous human studies indicate that the circulating renin-angiotensin system is relatively suppressed in posttransplant hypertension. 30 EDRF, endothelium-derived relaxing factor. There is considerable disparity between experimental and human studies regarding the mechanisms of vascular control altered by cyclosporine.…”

Section: Pathogenesismentioning

confidence: 99%

De novo hypertension after liver transplantation.

Textor

1993

Hypertension

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Hypertension develops in most patients after transplantation when immunosuppression is based on cyclosporine and prednisone. The pathogenesis appears to be multifactorial but involves rapidly rising vasoconstrictor tone in renal and systemic vascular beds. Much of this tone reflects abnormal vascular function, characterized by impaired prostacyclin and EDRF effects, in conjunction with increased vasoconstriction due to endothelin and possibly other factors. Effective management of the transplant recipient depends on preventing excessive vasoconstriction, usually with calcium channel blocking agents.

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Section: Pathogenesismentioning

confidence: 99%

De novo hypertension after liver transplantation.

Textor

1993

Hypertension

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“…Bantle 29 in kidney transplant recipients and by Bellet 37 in heart transplant recipients showed no stimulation of the system in view of normal PRA values. These results were interpreted as the result of extracellular fluid volume expansion.…”

Section: Introductionmentioning

confidence: 85%

Effects of transplantation on the renin angiotensin system (RAS)

Farge

Julien

1998

J Hum Hypertens

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Hypertension in organ transplant recipients is associated with several functional modifications of the renin angiotensin system (RAS), which varies according to the type of transplanted organs (kidney, heart, liver or bone marrow) and the immunosuppressive regimen. Before transplantation, chronic organ failure is associated with direct and indirect stimulation of both systemic and local RASs. After transplantation, cyclosporin per se is the major determinant of hypertension. It induces

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“…54 A defect in sensing and responding to changes in central volume resulting from cardiac denervation could also result in abnormal regulation of sodium and water balance. 45 Blunted excretion of sodium could contribute to the increased plasma volume reported by Bellet 55 and Braith 49 resulting in a diminished day-night difference in central blood volume. Braith et al 49 reported a 14% increase in extracellular fluid volume in cardiac transplant recipients who became hypertensive, which was not seen in liver transplant recipients or controls.…”

Section: Sodium Balance and Extracellular Fluid Volumementioning

confidence: 99%

“…93 In a further study, Bellet et al 55 looked at 15 cardiac transplant recipients on cyclosporin under standardised conditions, and found a 15% increase in plasma volume, but normal levels of plasma renin activity, aldosterone, angiotensinogen and angiotensin-converting enzyme.…”

Section: Cyclosporin and Vasodilator Activitymentioning

confidence: 99%

Hypertension in thoracic transplant recipients

Jenkins

Singer

1998

J Hum Hypertens

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There are many mechanisms underlying the hypertension which occurs after thoracic transplantation. Previous disease, effects of cyclosporin, tacrolimus and steroid immunosuppression and cardiac denervation are major contributory factors. Abnormal sodium and water balance is an important common mediating factor. A new approach is clearly needed for classifying the severity of hypertension in these patients taking into account day-night variation and total blood pressure

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Systemic hypertension after cardiac transplantation: Effect of cyclosporine on the renin-angiotensin-aldosterone system

Cited by 136 publications

References 17 publications

De novo hypertension after liver transplantation.

De novo hypertension after liver transplantation.

Effects of transplantation on the renin angiotensin system (RAS)

Hypertension in thoracic transplant recipients

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