Systemic Fat Embolism after Renal Homotransplantation and Treatment with Corticosteroids

Jones, John Paul; Engleman, Ephraim P.; Najarían, John S.

doi:10.1056/nejm196512302732703

Cited by 105 publications

(10 citation statements)

References 17 publications

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“…28,29 It would also be beneficial for non-orthopaedic practising physicians since ONFH is often associated with other medical problems. 1,15,16,[30][31][32][33] The JIC diagnostic criteria are met, but the accuracy and efficacy of the criteria have to be clarified and simplified. The specificity of the previous major criteria was high and appropriate for diagnosis but that of minor criteria was lower and of limited value.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic criteria for non-traumatic osteonecrosis of the femoral head

Sugano

Kubo

Takaoka

et al. 1999

The Journal of Bone and Joint Surgery. British volume

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S ix major and seven minor diagnostic criteria have been developed by the Japanese Investigation Committee for osteonecrosis of the femoral head (ONFH). We have carried out a multicentre study to clarify these. We studied prospectively 277 hips in 222 patients, from six hospitals, who had ONFH and other hip pathology and from whom histological material was available. We identified five criteria with high specificity: 1) collapse of the femoral head without narrowing of the joint space or acetabular abnormality on radiographs, including the crescent sign; 2) demarcating sclerosis in the femoral head without narrowing or acetabular abnormality; 3) a 'cold-in-hot' appearance on the bone scan; 4) a low-intensity band on T1-weighted images (band pattern); and 5) evidence of trabecular and marrow necrosis on histological examination. With any combination of two of these criteria, the sensitivity and specificity of the diagnosis were 91% and 99%, respectively.

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Section: Discussionmentioning

confidence: 99%

Diagnostic criteria for non-traumatic osteonecrosis of the femoral head

Sugano

Kubo

Takaoka

et al. 1999

The Journal of Bone and Joint Surgery. British volume

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“…Vascular injury due to steroid induced osteoporosis and microrotrauma was suggested [ 40 ]. Steroid induced thrombi due to hypercoagulability was proposed [ 41 ]; others theorized that steroids induced fatty liver could cause fatty emboli [ 42 - 44 ] leading to decreased perfusion and osteocyte death. There are also those who feel that an increased intraosseous pressure due steroid induced lipid infiltration could cause an external obstruction leading to AVN [ 20 ].…”

Section: Reviewmentioning

confidence: 99%

Avascular necrosis in pediatric systemic lupus erythematosus: a brief report and review of the literature

et al. 2015

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ᅟAvascular necrosis (AVN) occurs in several chronic illnesses, including systemic lupus erythematosus (SLE), but can also occur in healthy children. There are multiple theories to explain why and how AVN occurs, but an exact mechanism has yet to be unraveled. AVN in the pediatric lupus population is understudied. The Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) trial, provides an excellent venue to conduct an exploratory analysis to assess associations between AVN and demographics, SLE disease activity and vitamin D deficiency. Herein we present a brief report describing our findings, as well as reviewing the literature on AVN in SLE and other entities.Trial registrationClinicalTrials.gov identifier: NCT00065806.

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“…En animales de experimentación y en humanos se ha observado que la administración prolongada de glucocorticoides puede provocar la degeneración hidrópica de los hepatocitos, esteatosis, necrosis focales e hialina alcohólica (203). A pesar de su habitual intrascendencia, hay observaciones publicadas de embolias grasas sistémicas en el curso del tratamiento con corticoides e incluso durante la fase de retirada (204).…”

Section: Glucocorticoidesunclassified

Manifestaciones hepatobiliares en la enfermedad inflamatoria intestinal

Herruzo

Solís‐Muñoz

2007

Rev. esp. enferm. dig.

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Systemic Fat Embolism after Renal Homotransplantation and Treatment with Corticosteroids

Cited by 105 publications

References 17 publications

Diagnostic criteria for non-traumatic osteonecrosis of the femoral head

Diagnostic criteria for non-traumatic osteonecrosis of the femoral head

Avascular necrosis in pediatric systemic lupus erythematosus: a brief report and review of the literature

Manifestaciones hepatobiliares en la enfermedad inflamatoria intestinal

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