Systemic Essential Metal and Metalloid Levels in Patients with Benign Breast Disease and Breast Cancer

Skalny, Anatoly V.; Sekacheva, Marina; Aschner, Michael; Lobanova, Yulia N.; Tinkov, Alexey A.

doi:10.1007/s12011-022-03109-6

Cited by 2 publications

(2 citation statements)

References 51 publications

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“…The RT-PCR results showed that FAM83A was present in both breast cancer cell lines MDA-MB-231 and MCF-7 Da ( Figure 2(a) ). Of the 5 breast cancer tissues, 3 were highly expressed, and none was expressed in the responding paracancerous tissues and breast fibromas [ 32 ].…”

Section: Resultsmentioning

confidence: 99%

Bioinformatics Method Was Used to Analyze the Highly Expressed Gene FAM83A of Breast Cancer in Young Women

Tang

Wang

et al. 2022

Applied Bionics and Biomechanics

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Objectives. Preliminary analysis of breast cancer related to unknown functional gene FAM83A through bioinformatics knowledge to inform further experimental studies. Select high expression genes for breast cancer and use bioinformatics methods to predict the biological function of FAM83A. Methods. Genes with significant differences in expression between breast tumors and normal breast tissue libraries were selected from CGAP’s SAGE Digital Gene Expression Displayer (DGED) database. An unknown functional gene, FAM83A, which is highly expressed in breast cancer, was screened. We performed an analysis of the gene structure, subcellular localization, physicochemical properties of the encoding products, functional sites, protein structure, and functional domains. Results. Through SAGE DGED, a total of 185 genes with expression differences were found. The structure and function of FAM83A have ideal predictions, and it is generally determined that this gene encodes a nuclear protein with a nucleoprotein. The active site of PLDc and the functional domain of DUF1669 can be involved in signal transduction and gene expression regulation in tumorigenesis and metastasis. Digital gene representation of the Tumor Genome Project Data Library was used to select differentially expressed genes in breast cancer tissue and breast benign tumor tissue. Conclusion. Studies show that FAM83A is a potential research target associated with tumorigenesis and metastasis. Initial tests confirmed the expression of this gene. Lay a solid foundation for further research learning. FAM83A is a highly expressed gene in breast cancer and can serve as a target for studying molecular mechanisms in breast cancer.

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Section: Resultsmentioning

confidence: 99%

Bioinformatics Method Was Used to Analyze the Highly Expressed Gene FAM83A of Breast Cancer in Young Women

Tang

Wang

et al. 2022

Applied Bionics and Biomechanics

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“…Hair samples may be easily obtained and processed for the determination of trace element concentrations. Several studies proposed mineral analyses of hair in correlation with oncological [17][18][19] neurological [20,21], or metabolic [2,22,23] diseases. Trace element concentrations in blood, hair, urine, or vessel samples were also analyzed in cardiovascular diseases, including coronary and carotid artery disease and aortic valve disease [8,[24][25][26].…”

Section: Discussionmentioning

confidence: 99%

The Diagnostic Value of Trace Metal Concentrations in Hair in Carotid Artery Disease

Olasińska-Wiśniewska,

Urbanowicz,

Hanć

et al. 2023

JCM

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Several studies showed the role of trace elements in the increase in human susceptibility to cardiovascular diseases. Carotid artery stenosis is a leading cause of ischemic neurological events. We aimed to analyze the potential role of trace elements in hair as biomarkers of atherosclerotic carotid artery disease. Materials and Methods: Fifty-seven (n = 31 (54%) men and n = 26 (46%) women) individuals with a mean age of 67.7 ± 7.7 years who were white, European, non-Hispanic, and non-Latino were diagnosed and treated in hypertensiology/internal medicine and surgical departments over three consecutive months. Of these patients, forty were diagnosed with advanced carotid artery disease, and seventeen comprised a group of healthy controls. Inflammatory and oncological diseases were exclusion criteria. Hair samples were collected, and 14 trace elements were analyzed. Clinical and laboratory data were compared and revealed differences in the co-existence of diabetes (p = 0.036) and smoking history (p = 0.041). In the multivariable analysis, zinc, chrome, and copper revealed predictive value for the occurrence of carotid artery disease, and their combined receiver operating curve showed area under the curve of 0.935, with a sensitivity of 95% and a specificity of 82.4%. Conclusion: Our report shows the significance of trace elements analyses in patients with advanced carotid artery disease. We revealed that zinc, copper, and chrome concentrations are of particular importance in differentiating atherosclerotic disease and may serve as biomarkers of carotid atherosclerosis. Hair samples represent an easily obtained and beneficial biomatrix for the assessment of biomarkers.

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Systemic Essential Metal and Metalloid Levels in Patients with Benign Breast Disease and Breast Cancer

Cited by 2 publications

References 51 publications

Bioinformatics Method Was Used to Analyze the Highly Expressed Gene FAM83A of Breast Cancer in Young Women

Bioinformatics Method Was Used to Analyze the Highly Expressed Gene FAM83A of Breast Cancer in Young Women

The Diagnostic Value of Trace Metal Concentrations in Hair in Carotid Artery Disease

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