Systemic Effects of Photobiomodulation on Blood Components in the Treatment of Community-Acquired Pneumonia

Cardiopulmonary and hematological effects of infrared LED photobiomodulation in the treatment of SARS-COV2

“…This clinical trial demonstrated the beneficial effects of photobiomodulation in patients with COVID-19 symptoms, corroborating other data reported in the scientific literature on the anti-inflammatory effects of this technique on lung tissues in both animal and human models [ 5 , 17 , 20 , [28] , [29] , [30] , [31] , 38 , 39 ].…”

“…Data from this study and those reported by Pereira et al [ 17 ] agree with the findings of de Brito et al [ 20 ], who verified a systemic effect of LLLT (780 nm and 30 mW) on the reduction of inflammatory cell counts in the blood of animals with idiopathic pulmonary fibrosis, noting that, in relation to cytokines, LLLT reduced the release of pro-inflammatory cytokines and increased IL-10, justifying the anti-inflammatory effect presented by the photobiomodulation [ 20 ].…”

“…A statistically significant reduction was observed in this study for the count of leukocytes, neutrophils, and lymphocytes after therapy when infrared LED was combined with conventional treatment ( p < 0.05); however, no significant reduction was observed in patients who received only medication and physiotherapy ( p > 0.05). In a study by Pereira et al [ 17 ], patients with community-acquired pneumonia (CAP) who were treated with LED therapy showed a significant reduction in the number of leukocytes, neutrophils, lymphocytes, and monocytes.…”

“…The LED irradiation protocol is described in Pereira and coworkers' article [ 17 ]. Briefly, the LED system consisted of a set of 300 infrared LEDs (940 nm) with an optical power of 0.02 W each.…”

“…The photobiomodulation technique can modify cellular and molecular metabolism, signaling, reducing inflammation and release of chemical messengers, with promising results in reducing acute pulmonary inflammation, as they present significant potential for local balancing of immune responses [ 15 , 16 ]. In the last few decades, photobiomodulation has been used in the treatment of community-acquired pneumonia (CAP) with promising results regarding pulmonary inflammatory response and significant effects on the recovery of patients' blood count [ 17 ].…”