Systemic Delivery of Melanotan II through the Ocular Route in Rabbits

Pinsuwan, Sirirat; Myrdal, Paul B.; Yalkowsky, Samuel H.

doi:10.1021/js9604265

Cited by 9 publications

(1 citation statement)

References 14 publications

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“…He showed that a Gelfoam insert produces both prolonged and efficient miosis in rabbits. Pinsuwan et al 16,17 showed that Gelfoam is an excellent vehicle for systemic delivery of melanotan II, a cyclic heptapeptide. Recently, Simamora et al 18,19 demonstrated that Gelfoam is a useful eye insert in the systemic delivery of sodium bovine insulin to rabbits.…”

Section: Introductionmentioning

confidence: 99%

Effect of Brij-78 on Systemic Delivery of Insulin from an Ocular Device

Lee

Simamora

Yalkowsky

1997

Journal of Pharmaceutical Sciences

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An ocular insert is developed for the controlled systemic delivery of insulin. Commercially available Gelfoam absorbable gelatin sponge, USP, is used in the fabrication of the ocular insert in the form of a matrix system. Two eyedrop formulations and 13 eye device formulations were evaluated. The efficacy of insulin ocular delivery was quantitated by monitoring the changes in its pharmacological response (i.e., blood glucose lowering). The in vivo results from devices containing 0.5 or 1.0 mg of insulin with 20 micrograms of polyoxyethylene-20-stearyl ether (Brij-78) give a substantial improvement in insulin activity and a significant prolongation in its duration compared with the eyedrops. In addition, the mean blood glucose concentration returns to nearly normal levels within 60 min after the removal of the device. Overall, the application of the Gelfoam device makes it feasible to obtain a prolonged systemic delivery of insulin within the desired therapeutic levels without the risk of hypoglycemia.

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Section: Introductionmentioning

confidence: 99%