Systemic control of the molecular, cell, and epigenetic mechanisms of long-lasting consequences of stress

Immediate and Delayed Effects of Hypobaric Hypoxia during Early Postnatal Period on the Functioning of Digestive Enzymes

“…It can be hypothesized that changed functioning of enzymes of the small intestine in adult animals after stress exposure during the early ontogeny can be explained by modifi cations at the epigenetic level. There are no direct evidence concerning the mechanism of these changes in activity of the small intestine enzymes, but the epigenetic mechanism of post-stress regulation was clearly demonstrated on other objects [2,3,8,10,12,13]. This work was supported by grant of the President of the Russian Federation for young Russian Scientists and Leading Scientifi c Schools (NSh-1434.2008.4).…”

Selected rat strains HT, LT as a model for the study of dysadaptation states dependent on the level of excitability of the nervous system

“…These characteristics allow the usage of these strains as model objects for studies on the post-stress anxiety disorders, in particular, post-traumatic stress disorder (PTSD) and compulsive disorder (CD). The long-term effects of stress are based on the morphological changes of neurons in various brain structures, differential chromatin modifications in neurons and other somatic cells associated with epigenetic DNA and histone modifications [3,4]. The horizons of using the HT and LT strains for the elucidating genetic and epigenetic mechanisms of dysadaptation in response to environmental factors in terms of a personified medicine with a glance on the nervous system excitability are discussed.…”