Systemic Contact Dermatitis from Propylene Glycol

Lowther, Abigail; McCormick, Thomas S.; Nedorost, Susan T.

doi:10.2310/6620.2008.07037

Cited by 36 publications

(13 citation statements)

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“…In humans, there is documented evidence of contact dermatitis resulting from exposure to many of the ingredients in SUPER PRO Aloe Shampoo SP‐2 including aloe vera, 12 chamomile, 13 cocamidopropyl betaine, 14 cocamide DEA, 15 glycerine, 16 propylene glycol 17 and sodium chloride 18 . However, to our knowledge, there are no reported cases of contact dermatitis due to these ingredients in the veterinary literature.…”

Section: Discussionmentioning

confidence: 97%

A case of superficial suppurative necrolytic dermatitis of miniature schnauzers with identification of a causative agent using patch testing

Murayama¹,

Midorikawa

Nagata³

2008

Veterinary Dermatology

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A 9-year-old, castrated male, miniature schnauzer presented with malaise, anorexia, fever and severe inflammatory skin lesions on the dorsum, thighs and pinnae. The lesions developed 2 days after bathing with a commercial shampoo. Histopathological examination of skin samples revealed neutrophilic exocytosis, parakeratosis, epidermal hyperplasia and neutrophilic infiltration in the superficial dermis. Skin lesions resolved completely after 14 days of treatment with prednisolone and ofloxacin. Patch testing performed on the patient and a clinically healthy dog showed erythema at the site exposed to the culprit shampoo 48 h later only on the patient. Histopathological findings of the erythematous reaction were similar to those of the spontaneous skin lesions. Based on these findings, the dog was diagnosed with superficial suppurative necrolytic dermatitis of miniature schnauzers. The patch test results suggested that contact dermatitis to a commercial shampoo played a role in the pathogenesis of this disease.

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Section: Discussionmentioning

confidence: 97%

A case of superficial suppurative necrolytic dermatitis of miniature schnauzers with identification of a causative agent using patch testing

Murayama¹,

Midorikawa

Nagata³

2008

Veterinary Dermatology

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“…Fragrance mix I is a combination of eight chemical fragrances that is commonly used in PCPs, perfumes, lotions, and detergents, as well as in the workplace 30,31 . Propylene glycol is a ubiquitous allergen used in PCPs, medications, and foods as an emollient and an emulsifier 32,33 . Positive reactions to propylene glycol were found in similar proportions in those with and without NE.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and trend of allergen sensitization in patients with nummular (discoid) eczema referred for patch testing: North American Contact Dermatitis Group data, 2001–2016

et al. 2021

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Background Few studies have examined the relationship between nummular (discoid) eczema (NE) and allergic contact dermatitis (ACD). Objective To examine trends, associations, and clinical relevance of ACD in patients with NE who were referred for patch testing. Methods Retrospective analysis of 38 723 patients from the North American Contact Dermatitis Group. Results Overall, 748 patients (1.9%) were diagnosed with NE; 23.9% had a concomitant diagnosis of ACD. The prevalence of NE fluctuated over time between 2001 and 2016, with no overall change in prevalence in diagnosed NE. In multivariable logistic regression models, NE increased steadily with age and was associated with male sex and Asian and other race/ethnicity, and inversely associated with a history of atopic dermatitis (AD) and hay fever. Patients with NE had lower proportions of one or more positive allergic reactions and lower odds of a positive reaction in multiple individual allergens. The most commonly relevant allergens in patients with NE were formaldehyde 2.0% aq., methylisothiazolinone, quaternium 15, fragrance mix I, and propylene glycol. Conclusion NE is a heterogeneous disorder with distinct subsets of lesional distributions and a profile of relevant allergens, especially formaldehyde and formaldehyde releasers. Nearly one in four patients with NE had ACD, supporting the role of patch testing in patients with NE.

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“…Two of the patients had flares of their vesicular hand eczema after challenge with parabens but not the placebo. Butylhydroxyanisole and butylhydroxytoluene have been implicated as the cause of systemic contact dermatitis, 96 as have sorbic acid, 97 propylene glycol 98 , and formaldehyde 99 (Table 1).…”

Section: Mercurymentioning

confidence: 99%

“…Butylhydroxyanisole and butylhydroxytoluene have been implicated as the cause of systemic contact dermatitis, 96 as have sorbic acid, 97 propylene glycol 98 , and formaldehyde 99 (Table 1).…”

Section: Other Substances That Can Cause Systemic Contact Dermatitismentioning

confidence: 99%

Systemic contact dermatitis

Veien¹

2011

Int J Dermatology

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Systemic contact dermatitis is an inflammatory skin disease that may occur in persons with contact allergy when they are exposed to the hapten orally, transcutaneously, per rectum, intravesically, intravenously, or by inhalation. The most common causes of systemic contact dermatitis are drugs used both topically and systemically. Other causes are ubiquitously occurring haptens, such as the metals nickel, cobalt, gold, and chromate, and aromatic substances such as spices. Avoidance of the offending hapten is the most obvious treatment. For some haptens, such as nickel, diet treatment may be effective. Chelation therapy with disulfiram is another therapeutic option in nickel-allergic patients with systemic contact dermatitis. Hyposensitization therapy has been attempted with some success in systemic contact dermatitis caused by nickel and Parthenium hysterophorus.

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Systemic Contact Dermatitis from Propylene Glycol

Cited by 36 publications

References 0 publications

A case of superficial suppurative necrolytic dermatitis of miniature schnauzers with identification of a causative agent using patch testing

A case of superficial suppurative necrolytic dermatitis of miniature schnauzers with identification of a causative agent using patch testing

Prevalence and trend of allergen sensitization in patients with nummular (discoid) eczema referred for patch testing: North American Contact Dermatitis Group data, 2001–2016

Systemic contact dermatitis

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