Systemic Co-delivery of drugs by a pH- and photosensitive smart nanocarrier to treat cancer by chemo-photothermal-starvation combination therapy

Liu, Yixuan; Ding, Min; Guo, Kai; Wang, Zhengming; Zhang, Chengfei; Shubhra, Quazi T.H.

doi:10.1016/j.smaim.2022.05.003

Cited by 16 publications

(12 citation statements)

References 53 publications

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“…We followed the manufacturer’s protocol. We used the same reaction conditions following our previous study …”

Section: Methodsmentioning

confidence: 99%

“…Finally, absorbance was measured by a microplate reader (at 540 nm). We also observed the apoptosis of 1 × 10 4 cells by flow cytometer following our previously reported method …”

Section: Methodsmentioning

confidence: 99%

“…Currently, the number of pyroptotic agents/drugs is limited, and conventional drug delivery cannot avoid the high risk of pyroptosis in normal tissues . Hence, precise targeting of a pyroptotic agent is crucial to avoid their accumulation in healthy tissues, and that motivated us to develop a new DDS . To the best of our knowledge, there is no previous report on the dual targeting of breast cancer sites to precisely deliver a pyroptotic agent.…”

Section: Introductionmentioning

confidence: 99%

“…30 Hence, precise targeting of a pyroptotic agent is crucial to avoid their accumulation in healthy tissues, and that motivated us to develop a new DDS. 31 To the best of our knowledge, there is no previous report on the dual targeting of breast cancer sites to precisely deliver a pyroptotic agent. Moreover, pyroptosis−starvation−chemotherapeutic combination to treat breast cancer has not been reported yet.…”

Section: Introductionmentioning

confidence: 99%

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Engineered Magnetic Polymer Nanoparticles Can Ameliorate Breast Cancer Treatment Inducing Pyroptosis–Starvation along with Chemotherapy

Liu

Guo

Ding

et al. 2022

ACS Appl. Mater. Interfaces

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Nanotechnology has shown a revolution in cancer treatments, including breast cancers. However, there remain some challenges and translational hurdles. Surgery, radiotherapy, and chemotherapy are the primary treatment methods for breast cancer, although drug combinations showed promising results in preclinical studies. Herein we report the development of a smart drug delivery system (DDS) to efficiently treat breast cancer by pyroptosis–starvation–chemotherapeutic combination. Cancer-starvation agent glucose oxidase was chemically attached to synthesized iron oxide nanoparticles which were entrapped inside poly(lactic-co-glycolic acid) along with apoptosis-associated speck-like protein containing a caspase recruitment domain plasmid and paclitaxel (PTX). An emulsion solvent evaporation method was used to prepare the DDS. The surface of the DDS was modified with chitosan to which aptamer was attached to achieve site-specific targeting. Hence, the prepared DDS could be targeted to a tumor site by both external magnet and aptamer to obtain an enhanced accumulation of drugs at the tumor site. The final size of the aptamer-decorated DDS was less than 200 nm, and the encapsulation efficiency of PTX was 76.5 ± 2.5%. Drug release from the developed DDS was much higher at pH 5.5 than at pH 7.4, ensuring the pH sensitivity of the DDS. Due to efficient dual targeting of the DDS, in vitro viability of 4T1 cells was reduced to 12.1 ± 1.6%, whereas the nontargeted group and free PTX group could reduce the viability of cells to 29.2 ± 2.4 and 46.2 ± 1.6%, respectively. Our DDS showed a synergistic effect in vitro and no severe side effects in vivo. This DDS has strong potential to treat various cancers.

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“…We followed the manufacturer’s protocol. We used the same reaction conditions following our previous study …”

Section: Methodsmentioning

confidence: 99%

“…Finally, absorbance was measured by a microplate reader (at 540 nm). We also observed the apoptosis of 1 × 10 4 cells by flow cytometer following our previously reported method …”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Engineered Magnetic Polymer Nanoparticles Can Ameliorate Breast Cancer Treatment Inducing Pyroptosis–Starvation along with Chemotherapy

Liu

Guo

Ding

et al. 2022

ACS Appl. Mater. Interfaces

Self Cite

View full text Add to dashboard Cite

show abstract

“…TdT-mediated dUTP Nick-End Labeling (TUNEL) staining. TUNEL staining was performed by using One-step TUNEL staining kit (Beyotime Institute of Biotechnology) followed manufacturer's instructions to observe the protective ability of asiaticoside to UV-induced apoptosis (22). HaCat cells (1x10 4 ) were seeded to confocal dishes and cultured in an incubator for 37˚C overnight.…”

Section: Determination Of Superoxide Dismutase (Sod)mentioning

confidence: 99%

Asiaticoside delays senescence and attenuate generation of ROS in UV‑exposure cells through regulates TGF‑β1/Smad pathway

Jiang

Zhou

2022

Exp Ther Med

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Advances and opportunities of polydopamine coating in biosensing: Preparation, functionality, and applications

Gao,

Zhang,

Pedrero

et al. 2024

Coordination Chemistry Reviews

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Systemic Co-delivery of drugs by a pH- and photosensitive smart nanocarrier to treat cancer by chemo-photothermal-starvation combination therapy

Cited by 16 publications

References 53 publications

Engineered Magnetic Polymer Nanoparticles Can Ameliorate Breast Cancer Treatment Inducing Pyroptosis–Starvation along with Chemotherapy

Engineered Magnetic Polymer Nanoparticles Can Ameliorate Breast Cancer Treatment Inducing Pyroptosis–Starvation along with Chemotherapy

Asiaticoside delays senescence and attenuate generation of ROS in UV‑exposure cells through regulates TGF‑β1/Smad pathway

Advances and opportunities of polydopamine coating in biosensing: Preparation, functionality, and applications

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