Systemic Chemotherapy for Advanced Esophageal Cancer

Agop, Y. Bedikian

doi:10.5144/0256-4947.1982.267

Cited by 1 publication

(2 citation statements)

References 6 publications

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“…These multidrug regimens gave complete remissions (determined by esophagogram and endoscopic examination) in 5% to 15% of the patients. 6,7 However, complete remissions determined by complete evaluation of esophagectomy surgical specimen are found in less than 5% of the cases. [7][8][9][10] Our phase I-II study showed that the multidrug regimen including fluorouracil, doxorubicin, cisplatin, and etoposide was well tolerated and quite effective.…”

Section: Discussionmentioning

confidence: 99%

“…Included in this group are fluorouracil with a response rate of 16%, bleomycin 15% to 22%, doxorubicin 15% to 19%, mitomycin C 15%, methotrexate 9% to 12%, lomustine 16%, vindesine 10%, cisplatin 22% to 24%, methyl-GAG 20%, and etoposide 22%. 6,7 These drugs rarely induce complete remissions. Evaluation of multidrug regimens showed only modest increases in response rate and survival duration.…”

Section: Discussionmentioning

confidence: 99%

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Preoperative Chemotherapy in the Management of Esophageal Carcinoma: Preliminary Report

1988

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Carcinoma of the esophagus is the most common malignancy of the digestive system seen in our institution. Since mid-1982, a multidrug regimen including fluorouracil, doxorubicin, cisplatin, and etoposide was used for the therapy of this malignancy. Twenty-four patients with squamous cell carcinoma of the esophagus received two cycles of chemotherapy followed by surgery. The resectability rate was 84%. The surgical mortality was 8%. Chemotherapy induced four complete remissions (no residual malignancy in the esophagectomy specimen) and 13 partial remissions. It was well tolerated. The median follow-up from time of surgical resection is 8+ months (range, 1 to 32+ months). To date, five of 18 patients who had tumor resection have developed recurrence of the malignancy. This multidrug chemotherapy regimen is effective against squamous cell carcinoma of the esophagus and has increased the resectability of the tumor when given preoperatively. Further follow-up is needed to determine the effect of the treatment on survival.

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