1982
DOI: 10.5144/0256-4947.1982.267
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Systemic Chemotherapy for Advanced Esophageal Cancer

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1988
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(2 citation statements)
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“…These multidrug regimens gave complete remissions (determined by esophagogram and endoscopic examination) in 5% to 15% of the patients. 6,7 However, complete remissions determined by complete evaluation of esophagectomy surgical specimen are found in less than 5% of the cases. [7][8][9][10] Our phase I-II study showed that the multidrug regimen including fluorouracil, doxorubicin, cisplatin, and etoposide was well tolerated and quite effective.…”
Section: Discussionmentioning
confidence: 99%
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“…These multidrug regimens gave complete remissions (determined by esophagogram and endoscopic examination) in 5% to 15% of the patients. 6,7 However, complete remissions determined by complete evaluation of esophagectomy surgical specimen are found in less than 5% of the cases. [7][8][9][10] Our phase I-II study showed that the multidrug regimen including fluorouracil, doxorubicin, cisplatin, and etoposide was well tolerated and quite effective.…”
Section: Discussionmentioning
confidence: 99%
“…Included in this group are fluorouracil with a response rate of 16%, bleomycin 15% to 22%, doxorubicin 15% to 19%, mitomycin C 15%, methotrexate 9% to 12%, lomustine 16%, vindesine 10%, cisplatin 22% to 24%, methyl-GAG 20%, and etoposide 22%. 6,7 These drugs rarely induce complete remissions. Evaluation of multidrug regimens showed only modest increases in response rate and survival duration.…”
Section: Discussionmentioning
confidence: 99%