Systemic, but not pulmonary, hemodynamics are depressed during combined high thoraco-cervical epidural and general anesthesia in dogs

Funayama, Tadahisa; Aida, Sumihisa; Matsukawa, Takashi; Okada, Kazuo; Kumazawa, Teruo

doi:10.1007/bf03021056

Cited by 6 publications

(2 citation statements)

References 15 publications

(17 reference statements)

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“…Machala et al [ 4 ] studied the hemodynamic effects of propofol, found that propofol increased the pulmonary mean arterial pressure and afterload on the right ventricle. Funayama and his group [ 5 ] combined high thoraco-cervical epidural and general anesthesia in dogs found that propofol altered neither the pulmonary mean arterial pressure nor the pulmonary vascular resistance, but did decrease systemic vascular resistance. Another study [ 6 ] compared vasorelaxation induced by propofol in the intrapulmonary artery (IPA) and tehe extrapulmonary artery (EPA) and concluded that the response was significantly greater in the EPA than the IPA at higher drug concentrations.…”

Section: Introductionmentioning

confidence: 99%

The bifunctional effect of propofol on thromboxane agonist (U46619)-induced vasoconstriction in isolated human pulmonary artery

Hao

Wang

Kuang

et al. 2017

Korean J Physiol Pharmacol

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Propofol is known to cause vasorelaxation of several systemic vascular beds. However, its effect on the pulmonary vasculature remains controversial. In the present study, we investigated the effects of propofol on human pulmonary arteries obtained from patients who had undergone surgery. Arterial rings were mounted in a Multi-Myograph system for measurement of isometric forces. U46619 was used to induce sustained contraction of the intrapulmonary arteries, and propofol was then applied (in increments from 10–300 µM). Arteries denuded of endothelium, preincubated or not with indomethacin, were used to investigate the effects of propofol on isolated arteries. Propofol exhibited a bifunctional effect on isolated human pulmonary arteries contracted by U46619, evoking constriction at low concentrations (10–100 µM) followed by secondary relaxation (at 100–300 µM). The extent of constriction induced by propofol was higher in an endothelium-denuded group than in an endothelium-intact group. Preincubation with indomethacin abolished constriction and potentiated relaxation. The maximal relaxation was greater in the endothelium-intact than the endothelium-denuded group. Propofol also suppressed CaCl2-induced constriction in the 60 mM K+-containing Ca2+-free solution in a dose-dependent manner. Fluorescent imaging of Ca2+ using fluo-4 showed that a 10 min incubation with propofol (10–300 µM) inhibited the Ca2+ influx into human pulmonary arterial smooth muscle cells induced by a 60 mM K+-containing Ca2+-free solution. In conclusion, propofol-induced arterial constriction appears to involve prostaglandin production by cyclooxygenase in pulmonary artery smooth muscle cells and the relaxation depends in part on endothelial function, principally on the inhibition of calcium influx through L-type voltage-operated calcium channels.

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Section: Introductionmentioning

confidence: 99%

The bifunctional effect of propofol on thromboxane agonist (U46619)-induced vasoconstriction in isolated human pulmonary artery

Hao

Wang

Kuang

et al. 2017

Korean J Physiol Pharmacol

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“…Thoracic epidurals have been associated with decreased sympathetic tone (9,10) with a negative influence on cardiac output (11,12) but enhanced blood flow to the blocked region (13). Blood flow to the vagina is regulated by thoracolumbar sympathetic nuclei via the hypogastric nerve (14).…”

mentioning

confidence: 99%

Orthogonal Polarization Spectral Imaging of the Microcirculation During Acute Hypervolemic Hemodilution and Epidural Lidocaine Injection

Oever¹,

Dzoljic²,

İnce³

et al. 2006

Anesthesia &Amp; Analgesia

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We used Orthogonal Polarization Spectral Imaging to examine the microcirculation of the vaginal mucosa in nine anesthetized patients during two consecutive anesthetic interventions: hypervolemic hemodilution using hydroxyethyl starch followed by thoracic epidural lidocaine. Images taken before and after each intervention were compared. During hypervolemic hemodilution, systolic blood pressures increased significantly, but functional capillary density remained unchanged. Epidural anesthesia decreased systolic and diastolic blood pressures, but there was no change in capillary density, venular diameter, or flow velocity. We concluded that when using Orthogonal Polarization Spectral imaging, no consistent effects on the microcirculation of the vaginal wall can be detected.

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Patient-controlled cervical epidural fentanyl compared with patient-controlled i.v. fentanyl for pain after pharyngolaryngeal surgery

Roussier

Mahul

Pascal

et al. 2006

British Journal of Anaesthesia

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Systemic, but not pulmonary, hemodynamics are depressed during combined high thoraco-cervical epidural and general anesthesia in dogs

Abstract: P Pu ur rp po os se e: : An epidural block is frequently combined with general anesthesia. Both systemic and pulmonary hemodynamics may be affected by high epidural anesthesia and the combined general anesthetic. These effects were investigated in a canine model.

Cited by 6 publications

References 15 publications

The bifunctional effect of propofol on thromboxane agonist (U46619)-induced vasoconstriction in isolated human pulmonary artery

The bifunctional effect of propofol on thromboxane agonist (U46619)-induced vasoconstriction in isolated human pulmonary artery

Orthogonal Polarization Spectral Imaging of the Microcirculation During Acute Hypervolemic Hemodilution and Epidural Lidocaine Injection

Patient-controlled cervical epidural fentanyl compared with patient-controlled i.v. fentanyl for pain after pharyngolaryngeal surgery

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