“…Neonatal sepsis was defined as the growth of a single potentially pathogenic organism (bacterium or fungus) from blood or cerebrospinal fluid in infants with clinical and laboratory findings consistent with infection 13. EOS was defined as an infection among infants younger than 3 days while LOS among infants 3 days of birth or older.…”
The pattern of EOS in Asian settings is similar to that in industrialised countries with low incidence of GBS sepsis. The important features of neonatal sepsis in Asia are the burden of Klebsiella spp. and high level of antibiotic resistance. These should be addressed while developing measures to reduce neonatal mortality due to infection.
“…Neonatal sepsis was defined as the growth of a single potentially pathogenic organism (bacterium or fungus) from blood or cerebrospinal fluid in infants with clinical and laboratory findings consistent with infection 13. EOS was defined as an infection among infants younger than 3 days while LOS among infants 3 days of birth or older.…”
The pattern of EOS in Asian settings is similar to that in industrialised countries with low incidence of GBS sepsis. The important features of neonatal sepsis in Asia are the burden of Klebsiella spp. and high level of antibiotic resistance. These should be addressed while developing measures to reduce neonatal mortality due to infection.
The increasing use of intrapartum antibiotics produced a steady decline in EOGBS disease in Australasia. There was also a trend to decreasing EO E. coli sepsis in all babies, and the rate in very low birth weight infants remained stable.
“…In their 2000–2003 report, the World Health Organization estimated that neonatal sepsis and pneumonia are responsible for about 1.6 million deaths each year, mainly in resource-poor countries 1. Antibiotic resistance is an important problem in resource-poor countries,2 – 5 and a survey of neonatologists in Asian countries suggested that there is a significant problem with sepsis caused by multi-resistant Gram-negative organisms and meticillin-resistant Staphylococcus aureus (MRSA) 6. Previous studies have reported rates of hospital-acquired neonatal infections that are 3–20 times higher in resource-poor than resource-rich countries 3.…”
The incidence of late-onset sepsis was higher in Asia than in resource-rich countries, but the organisms isolated and mortality were similar. Over half of all Gram-negative bacilli were antibiotic resistant.
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