Systemic assessment of fetal hemodynamics by Doppler ultrasound

Chang, Cheng-Yen; Chang, Feng-Cheng; Chen, Yu; Liang, Ren Ing; Ko, Huei Chen; Chen, Hsi Yao

doi:10.1016/s0301-5629(00)00207-6

Cited by 51 publications

(37 citation statements)

References 27 publications

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“…A slow decrease in IVCT was found, likely attributable to increasing ventricular pressure. This also has been reported in human fetuses (Leiva et al 1999;Chang et al 2000). As seen in previous mouse and human fetal echocardiography studies, both peak arotic and pulmonary outflow velocities increased with development (Gui et al 1996;Spurney et al 2004;Phoon et al 2000Phoon et al , 2004Leiva et al 1999;van der Mooren et al 1991;Chang et al 2000;Abuhamad et al 2004).…”

Section: Discussionsupporting

confidence: 85%

“…The E/A ratio was observed to increase as development progressed, which may be indicative of an overall increase in ventricular compliance in fetal mice (Gui et al 1996;Zhou et al 2003;Spurney et al 2004). This also has been observed in human fetuses from 20 weeks of gestation to term (van der Mooren et al 1991;Chang et al 2000;Abuamad et al 2004). A-wave inflow velocities were observed to be greater than outflow velocities between E12.5 to E14.5, which would further suggest atrial systolic function may play a significant role in supporting early fetal development.…”

Section: Discussionsupporting

confidence: 65%

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Cardiovascular Assessment of Fetal Mice by In Utero Echocardiography

Leatherbury

Tian

et al. 2008

Ultrasound in Medicine & Biology

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To establish a developmental profile of fetal mouse cardiovascular parameters, we analyzed a large body of ultrasound measurements obtained by in utero echocardiography of C57BL/6J fetal mice from embryonic day 12.5 to 19.5 (term). Measurements were obtained using 2D, spectral Doppler and M-mode imaging with standard clinical cardiac ultrasound imaging planes. As these studies were conducted as part of a large scale mouse mutagenesis screen, stringent filtering criteria were used to eliminate potentially abnormal fetuses. Our analysis showed heart rate increased from 190 to 245 bpm as the mouse fetus grew from 8 mm at embryonic day 12.5 to 18.7 mm at term. This was accompanied by increases in peak outflow velocity, E-wave, E/A ratio and ventricular dimensions. In contrast, the A-wave, myocardial performance index and isovolemic contraction time decreased gradually. Systolic function remained remarkably stable at 80% ejection fraction. Analysis of intra and interobserver variabilities showed these parameters were reproducible, with most comparing favorably to clinical ultrasound measurements in human fetuses. A comprehensive database was generated comprising 23 echocardiographic parameters delineating fetal mouse cardiovascular function from embryonic day 12.5 to term. This database can serve as a standard for evaluating cardiovascular pathophysiology in genetically altered and mutant mouse models.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionsupporting

confidence: 65%

Cardiovascular Assessment of Fetal Mice by In Utero Echocardiography

Leatherbury

Tian

et al. 2008

Ultrasound in Medicine & Biology

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“…Before the era of 3DPD, Doppler ultrasound by 2D real-time ultrasound had been widely used for evaluating uteroplacental and fetoplacental perfusion [14]. For example, umbilical Doppler is a powerful tool in clinical practice, particularly in the diagnosis and management of SGA fetuses.…”

Section: Dus: Benefits Versus Conflictsmentioning

confidence: 99%

A Review of Three-dimensional Ultrasound Applications in Fetal Growth Restriction

Lee

Chang

Cheng

et al. 2012

Journal of Medical Ultrasound

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KEY WORDSfetal growth restriction, three-dimensional ultrasound Fetal growth restriction (FGR), previously known as intrauterine growth restriction, remains one of the main challenges in maternity care. Three-dimensional ultrasound (3DUS) has the potential to provide improved visualization of the fetal anatomic morphology compared with conventional two-dimensional ultrasound imaging. The present paper reviews 3DUS studies in the diagnosis, evaluation and prediction of FGR, and discusses the possible clinical applications of 3DUS. ª

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“…Na atualidade, o diagnóstico de anemia fetal grave é realizado pela dopplervelocimetria na ACM do feto, evitando-se a realização de procedimentos invasivos 4,5 . Para a observação de complicações na circulação fetal e na adaptação hemodinâmica em fetos de risco é obrigatório reconhecer mudanças hemodinâmicas fetais durante a gestação normal 6 . Trabalhos recentes descrevem a hemodinâmica fetal por meio da dopplervelocimetria, demonstrando a interação entre o débito cardíaco e o sistema arterial e venoso fetal 6 , e por modelo artificial, que Todas as pacientes tinham gestação única, idade gestacional entre a 22ª e a 38ª semana, calculada pela data da última menstruação e/ou avaliação ultra-sonográfica do comprimento cabeça-nádega entre a 8ª e a 12ª semana de gestação.…”

Section: Introductionunclassified

“…Para a observação de complicações na circulação fetal e na adaptação hemodinâmica em fetos de risco é obrigatório reconhecer mudanças hemodinâmicas fetais durante a gestação normal 6 . Trabalhos recentes descrevem a hemodinâmica fetal por meio da dopplervelocimetria, demonstrando a interação entre o débito cardíaco e o sistema arterial e venoso fetal 6 , e por modelo artificial, que Todas as pacientes tinham gestação única, idade gestacional entre a 22ª e a 38ª semana, calculada pela data da última menstruação e/ou avaliação ultra-sonográfica do comprimento cabeça-nádega entre a 8ª e a 12ª semana de gestação. Não eram portadoras de enfermidades maternas associadas e/ou próprias da gestação, como também não eram usuárias de fumo, álcool ou drogas.…”

Section: Introductionunclassified

Velocidade sistólica máxima e índice de resistência de artérias fetais durante a segunda metade da gestação

Costa¹,

Filho²,

Spara³

et al. 2005

Rev. Bras. Ginecol. Obstet.

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RESUMOObjetivo: avaliar a velocidade sistólica máxima (VSM) e o índice de resistência (IR) nas artérias fetais cerebral média (ACM), aorta supra-renal (ASR), aorta infra-renal (AIR) e artéria umbilical (AU) . Conclusão: em fetos normais, na segunda metade da gestação, a VSM aumenta na ACM, ASR e AIR, diminuindo na AU entre a 34ª e a 38ª semana de gestação. O IR é menor na 22ª e 38ª semana de gestação na ACM, diminui entre a 22ª e a 38ª semana na AU e é constante na maioria das semanas gestacionais na ASR e AIR. Rev Bras Ginecol Obstet. 2005; 27(7): 387-92, PALAVRAS-CHAVE:

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Systemic assessment of fetal hemodynamics by Doppler ultrasound

Cited by 51 publications

References 27 publications

Cardiovascular Assessment of Fetal Mice by In Utero Echocardiography

Cardiovascular Assessment of Fetal Mice by In Utero Echocardiography

A Review of Three-dimensional Ultrasound Applications in Fetal Growth Restriction

Velocidade sistólica máxima e índice de resistência de artérias fetais durante a segunda metade da gestação

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