Systemic antimicrobials adjuvant to periodontal therapy in diabetic subjects: a meta‐analysis

Abstract

Adjunctive therapy may improve the efficacy of SRP in reducing PD in diabetic subjects.

Efficacy of systemic antibiotics in nonsurgical periodontal therapy for diabetic subjects: a systematic review and meta-analysis

“…These main findings are in agreement with the other two SRs. One of the SRs excluded one trial that was included in our review. The reason was that the final number of participants in the groups was not reported in the article.…”

Benefits of non‐surgical periodontal treatment in patients with type 2 diabetes mellitus and chronic periodontitis: A randomized controlled trial

“…This reinforces the hypothesis that the periodontal treatment improves glycaemic control (Costa et al., ). On the other hand, the meta‐analysis conducted by Grellmann, Sfreddo, Maier, Lenzi, and Zanatta () supports the additional effect of the use of systemic antibiotics in periodontal treatment. Although, antibiotic prescription should be restricted to particularly complicated clinical scenarios.…”

Empirical or microbiologically guided systemic antimicrobials as adjuncts to non‐surgical periodontal therapy? A systematic review

“…The use of antibiotic treatment as adjunctive to non‐surgical periodontal therapy was initially introduced to tackle the microbial aetiology of periodontitis (Baer & Socransky, ) and later on more specifically with the main aim to eliminate periodontopathogenic bacteria (such as Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis ) which are otherwise likely to persist following mechanical biofilm removal only (van Winkelhoff et al, ). Adjunctive antibiotic treatment was initially restricted to patients with juvenile periodontitis (Lindhe & Liljenberg, ), but then sometimes also extended to patients with chronic, adult forms of periodontitis (Winkel, Winkelhoff, Timmerman, Velden, & Weijden, ) and/or to diabetic patients with periodontitis (Grellmann, Sfreddo, Maier, Lenzi, & Zanatta, ). The adjunctive use of systemic antibiotics has shown to be beneficial, especially but not exclusively in patients with aggressive periodontitis, in terms of improvements in clinical parameters (probing pocket depths, PPD, and clinical attachment levels, CAL) compared with placebo (Haffajee, Socransky, & Gunsolley, ; Herrera, Sanz, Jepsen, Needleman, & Roldán, ; Jepsen & Jepsen, ; Sgolastra, Petrucci, Gatto, & Monaco, ; Smiley et al, ; Zandbergen, Slot, Niederman, & Weijden, ), although the long‐term stability of such improvements is probably highly influenced by the supportive periodontal therapy regime adopted (Ramberg et al, ).…”