Systemic antibiotic therapy of acne vulgaris

Ochsendorf, Falk

doi:10.1111/j.1610-0387.2006.06053.x

Cited by 61 publications

(41 citation statements)

References 55 publications

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“…Doxycycline is the preferred systemic antibiotic. Minocycline is no more effective but associated with rare yet potentially very serious adverse events such as drug rash with eosinophilia and systemic symptoms (DRESS) (details in [ 32,33 ] ).…”

Section: Selection Of the Appropriate Agentmentioning

confidence: 99%

“…Moreover, treatment with systemic antibiotics should be limited to three months. After this period, there is an increase in resistance and longer treatment has no additional benefi ts [ 31,32 ] . Systemic antibiotic therapy, too, should always be combined with topical agents such as retinoids and/or benzoyl peroxid (BPO) ( Table 2 ).…”

Section: Selection Of the Appropriate Agentmentioning

confidence: 99%

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Acne

Degitz

Ochsendorf

2017

J Deutsche Derma Gesell

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Summary Acne is a chronic disease with a high prevalence among adolescents. Key pathogenetic factors (and their clinical correlates) are increased sebum production (seborrhea), follicular hyperkeratosis (comedones), and perifollicular inflammation (papules and pustules). The disease is modulated by a variety of endogenous (androgens, IGF‐1, neuroendocrine factors) and exogenous (Propionibacterium acnes, diet, friction, ingredients of medical or cosmetic topical products) triggers. Acne is associated with high morbidity, and even mild manifestations may potentially cause considerable impairment in quality of life. Effective topical and systemic treatments are available. Optimal therapeutic results require continuous patient management over the course of the entire treatment period as well as adjustment of treatment modalities based on symptoms and disease severity.

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Section: Selection Of the Appropriate Agentmentioning

confidence: 99%

Section: Selection Of the Appropriate Agentmentioning

confidence: 99%

Acne

Degitz

Ochsendorf

2017

J Deutsche Derma Gesell

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“…Further study is needed to confirm and better understand these findings. Side effects of the tetracycline class include most commonly gastrointestinal complaints, such as nausea or vomiting [17]. Dose-dependent photosensitivity may be noted with doxycycline [18], and this class is contraindicated in pregnancy and children younger than 10, as it may cause yellow discoloration of the teeth and hypoplasia of tooth enamel [10,19].…”

Section: Existing Systemic Treatmentmentioning

confidence: 99%

Emerging drugs for acne

James

Burkhart

Morrell

2009

Expert Opinion on Emerging Drugs

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Acne vulgaris is a common skin disorder that affects most individuals at some point in their lives. It may result in significant morbidity, including cutaneous scarring and psychological impairment. Current treatments include topical retinoids, benzoyl peroxide, topical and systemic antibiotics, and systemic isotretinoin. There are growing concerns of rising antibiotic resistance, significant side effects of isotretinoin therapy, and lack of safe and effective treatment for pregnant females. Recent advances in the pathogenesis of acne have led to a greater understanding of the underlying inflammatory mechanisms and the role the Propionibacterium acnes and biofilms. This has led to the development of new therapeutic targets. This article reviews emerging treatments of acne, including topical picolinic acid, topical antibiotic dapsone, systemic zinc salts, oral antibiotic lymecycline, new formulations of and synergistic combinations of benzoyl peroxide, photodynamic therapy with topical photosensitizers and potential acne vaccines.

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“…Le choix de l'antibiotique n'est donc pas réalisé sur son efficacité mais sur la pharmacologie, les résistances, les effets secondaires, la tolérance et le coût. Les dérivés semi-synthétiques de la tétra-cycline ont un avantage pharmacologique : l'absorption est plus rapide, l'élimination plus lente et l'observance du traitement pour les patients plus aisée [16].…”

Section: Acné Et Traitements à Base De Tétracycline Ou Ses Dérivésunclassified

Colorations coronaire et radiculaire des troisièmes molaires dues aux tétracyclines : cas clinique et revue de littérature

Dubar¹,

Seckinger²,

Anastasio³

2014

Med Buccale Chir Buccale

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Pôle Tête, Cou, chirurgie plastique, chirurgie des brûlés, service d'odontologie, CHR Metz-Thionville, hôpital Bel-Air, Thionville, France (Reçu le 5 juin 2014, accepté le 28 septembre 2014) Résumé -Introduction : Les tétracyclines sont des antibiotiques à large spectre, connues depuis les années 1960 pour provoquer des colorations dentaires lors de l'odontogenèse. Leur prescription est contre-indiquée chez les enfants de moins de 8 ans et les femmes enceintes. Depuis les années 1990, les traitements contre l'acné inflammatoire modérée à sévère chez l'adolescent et le jeune adulte font systématiquement appel aux tétracyclines et ses dérivés semi-synthétiques. Un cas de colorations radiculaire et coronaire de troisièmes molaires visualisées après avulsion est rapporté dans cet article. Observation : Nous rapportons ici le cas d'une patiente âgée de 17 ans présentant des colorations jaune d'or en bandes au niveau coronaire et radiculaire de ses troisièmes molaires découvertes après leur avulsion, non présentes chez sa soeur jumelle. Ces dyschromies ont fait évoquer la prise d'un traitement à base de tétracycline. L'interrogatoire médical a confirmé la prise d'un traitement contre l'acné à base de lymécycline, dérivé semi-synthétique des tétracyclines, non pris par sa soeur. Discussion : La localisation et la teinte de la dyschromie concordaient avec la prise du traitement ; tout ceci était étayé par l'absence de coloration chez la soeur jumelle. Même si les colorations dentaires dues aux tétracyclines sont connues depuis longtemps, aucun article dans la littérature ne fait référence à des colorations qui seraient dues à la lymécycline.Abstract -Root and coronary stainings of the third molars caused by tetracyclines: case report and literature review. Introduction: Tetracyclines are broad-spectrum antibiotics, known since the 60s to cause tooth staining during odontogenesis. Their prescription is forbidden in children until 8 years of age and pregnant women. Since the 90s, treatments for moderate to severe inflammatory acne in teenagers and young adults always involve tetracyclines and their semi-synthetic derivates. This article relates a root and coronary staining case involving third molars discernible after being removed. Case report: This case report concerned a 17-year-old female patient with golden yellow strips which stained the third molars' roots and the crown. The staining was discovered after their extraction and was not present on the wisdom teeth of her twin sister. These dyschromias called to mind the absorption of a tetracycline-based treatment. Medical interrogation confirmed the intake of lymecycline (a semisynthetic tetracycline)-based treatment for acne which her twin sister was not treated with. Discussion: The dyschromia's localisation and shade agree with the taking of the treatment. Moreover, the lack of staining on the sister's tooth backs this assertion up. Although dental staining caused by tetracyclines has been known about for some time, there are no articles in the literature which ref...

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Systemic antibiotic therapy of acne vulgaris

Abstract: The systemic antibiotic therapy of widespread papulo-pustular acne not amenable to a topical therapy is effective and well-tolerated. In general therapy can be carried out for 3 months and should be combined with BPO to prevent resistance.

Cited by 61 publications

References 55 publications

Acne

Acne

Emerging drugs for acne

Colorations coronaire et radiculaire des troisièmes molaires dues aux tétracyclines : cas clinique et revue de littérature

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