Systemic antibiotic therapy in periodontics

Kapoor, Anoop; Malhotra, Ranjan; Grover, Vishakha; Grover, Deepak

doi:10.4103/1735-3327.104866

Cited by 284 publications

(73 citation statements)

References 26 publications

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“…Some clinical studies even mention the use of toremifene at a dose of 680 mg/day, which lies well within the range of recommended antibiotic dosages for treatment of oral infections (13,31). Regarding toxicity, toremifene is generally well tolerated by patients (13).…”

Section: Discussionmentioning

confidence: 99%

Repurposing Toremifene for Treatment of Oral Bacterial Infections

Gerits

Defraine

Vandamme

et al. 2017

Antimicrob Agents Chemother

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The spread of antibiotic resistance and the challenges associated with antiseptics such as chlorhexidine have necessitated a search for new antibacterial agents against oral bacterial pathogens. As a result of failing traditional approaches, drug repurposing has emerged as a novel paradigm to find new antibacterial agents. In this study, we examined the effects of the FDA-approved anticancer agent toremifene against the oral bacteria Porphyromonas gingivalis and Streptococcus mutans. We found that the drug was able to inhibit the growth of both pathogens, as well as prevent biofilm formation, at concentrations ranging from 12.5 to 25 M. Moreover, toremifene was shown to eradicate preformed biofilms at concentrations ranging from 25 to 50 M. In addition, we found that toremifene prevents P. gingivalis and S. mutans biofilm formation on titanium surfaces. A time-kill study indicated that toremifene is bactericidal against S. mutans. Macromolecular synthesis assays revealed that treatment with toremifene does not cause preferential inhibition of DNA, RNA, or protein synthesis pathways, indicating membrane-damaging activity. Biophysical studies using fluorescent probes and fluorescence microscopy further confirmed the membrane-damaging mode of action. Taken together, our results suggest that the anticancer agent toremifene is a suitable candidate for further investigation for the development of new treatment strategies for oral bacterial infections.

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Section: Discussionmentioning

confidence: 99%

Repurposing Toremifene for Treatment of Oral Bacterial Infections

Gerits

Defraine

Vandamme

et al. 2017

Antimicrob Agents Chemother

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“…32,33 Öte yandan hafif ya da orta düzeydeki kronik periodontitte ve jinjivitlerde antibiyotik tedavisine gerek yoktur. 68 Sistemik yayılım belirtilerinin olduğu, akut periodontal enfeksiyonlarda (nekrotizan ülseratif jinjivit, nekrotizan ülseratif periodontit ve periodontal apse) antibiyotik tedavisinden yararlanıl-maktadır. [67][68][69] Rejeneratif materyallerin kullanıldığı periodontal işlemler dâhil tüm cerrahi tedavilerde rasyonel gerekçeler bulunmadığı takdirde antibiyotik kullanımından kaçınılmalıdır.…”

Section: Peri̇odontoloji̇de Anti̇bi̇yoti̇k Kullanimiunclassified

The Rational Use of Antibiotics in Dentistry: Review

Aydın¹,

Koyuncuoğlu²,

Kilboz³

et al. 2017

Turkiye Klinikleri J Dental Sci

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“…Literature states that amoxicillin has been formed for treatment of periodontal disease because of its considerable activity against several periodontal pathogens at levels available in gingival fluid [6] .…”

Section: Historical Backgroundmentioning

confidence: 99%

“…Studies state that metronidazole affects specifically the obligately anaerobic part of oral flora including p gingivalis and other black pigmenting gram negative organisms but not A actinomycetemcomitans, a facultative anaerobes [6] .…”

Section: Historical Backgroundmentioning

confidence: 99%

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Highlights on role of antibiotics in periodontics

Shetty¹,

Bhandary²,

Thomas³

2016

Int J Dentistry Res

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Periodontal treatment aims at restoring a micro biota compatible with periodontal health. Scaling and root planing can be classified as 'THE GOLD STANDARD" of periodontal care and has been demonstrated to be successful in order to maintain periodontal health for more than 20 years. Whereas periodontal antibiotic therapy aims to reinforce mechanical periodontal treatment and to support host defense system in overcoming the infection by killing sub gingival pathogens that remains after conventional mechanical periodontal therapy. A number of key elements need to be considered such as the anti-biofilm strategies, drug resistance in biofilm, various routes of antibiotic administration, its efficacy, sequencing of antibiotics while administering antibiotics for periodontitis. Pencillin was the first antibiotic systemically administered; historical background of antibiotics is reviewed here. Earlier choice was based exclusively on empiric evidence but with time tetracycline, metronidazole and beta lactams are among the most widely used agents for treating periodontal condition. This review henceforth attempts to describe the rationale of antibiotics in periodontal therapy. There is also a collection of data from scientific papers clinically relevant to the periodontitis providing description of nature of biofilms in general, oral biofilms in particular as well as approaches to their control, behavior of antibiotics in oral biofilm, potential of systemic and locally applied antibiotic therapy to control the periodontopathic microbiota.

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Systemic antibiotic therapy in periodontics

Cited by 284 publications

References 26 publications

Repurposing Toremifene for Treatment of Oral Bacterial Infections

Repurposing Toremifene for Treatment of Oral Bacterial Infections

The Rational Use of Antibiotics in Dentistry: Review

Highlights on role of antibiotics in periodontics

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