Systemic antibiotic prophylaxis and reconstructive ear surgery

Carlin, W. V.; Lesser, T. H. J.; John, D. G.; Fielder, C. P.; Carrick, D. G.; Thomas, Ponnamma; Hill, Sharon

doi:10.1111/j.1365-2273.1987.tb00230.x

Cited by 13 publications

(9 citation statements)

References 12 publications

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“…The mean otorrhea score at day 1 was 0.33 (0-1.7), 1st month was 4.67 (1-5), 2nd month was 3.33 (1)(2)(3)(4), and 3rd month was 1.44 (1)(2)(3) in the study group. In the control group it was 0.30 (0-1.5) at day 1, 3.00 (1-5) at 1 month, 1.65 (0-4) at 2nd month, and 0.75 (0-2) at 3 months.…”

Section: Resultsmentioning

confidence: 80%

“…2) Both systemic antibiotics and topical antibiotics have been used in the postoperative period to eradicate infection and improve healing of the mastoid cavity. 3,4) However its use in routine mastoid surgery is controversial and there is a risk of antibiotic resistance. 5) Winerman, et al 6) stated that there was no role of prophylactic or postoperative antibiotics in uncomplicated mastoid surgery.…”

Section: Introductionmentioning

confidence: 99%

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Manuka Honey versus Antibiotic Ear Drops in Healing of Post-Operative Mastoid Cavity: A Prospective Randomized Trial

Damodharan

Verma

Angrup

et al. 2020

Korean J Otorhinolaryngol-Head Neck Surg

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Background and ObjectivesThis study investigates the role of manuka honey in the healing of postoperative mastoid cavity. Subjects and Method This was a single centre prospective study on 40 consecutive patients of chronic otitis media undergoing canal wall down mastoidectomy. Manuka honey soaked in gel foam was kept in the mastoid cavity for the study group and antibiotic soaked gel foam was kept for the control group. Culture swabs from mastoid granulations were sent at various times from both groups. The healing of the mastoid cavity was assessed in the follow up period. Results Preoperatively 15 out of 20 patients (75%) had a positive aural swab culture in the study group while 11 out of 20 (55%) in the control group had a positive aural swab culture. The most common organism isolated was Pseudomonas aeruginosa and Proteus mirabilis. One month after mastoidectomy only 4 patients (20%) had sterile culture and 16 patients (80%) had grown organisms; in the control group, 7 patients (35%) had sterile culture and 13 patients (65%) had growth on culture. The mean merchant scores for the study group and the control were 2.61 (2-5) and 2.05 (1-4), respectively. At 3 months 13 patients (65%) with sterile culture and 7 patients (35%) had growth on culture; in the control group, 16 patients (80%) had sterile culture and 4 had shown persistent growth on culture (p=0.28). All positive cultures were aerobic in both groups. The mean merchant scores for the study group and the control were 1.03 (0-4) and 0.7 (0-3), respectively (p=0.09). Conclusion Healing of mastoid cavity was almost similar in both groups (p>0.05). Manuka honey exhibited antibacterial activity against Pseudomonas, Proteus, Klebsiella, Escherichia coli, Staphylococcus. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. combination with antibiotics. Int J Bacteriol 2014;2014:795281. 13) Youngs R. The histopathology of mastoidectomy cavities, with particular reference to persistent disease leading to chronic otorrhoea. Clin Otolaryngol Allied Sci 1992;17(6):505-10. 14) Sutton DV, Derkay CS, Darrow DH, Strasnick B. Resistant bacteria in middle ear fluid at the time of tympanotomy tube surgery. Ann Otol Rhinol Laryngol 2000;109(1):24-9. 15) Sojka M, Valachova I, Bucekova M, Majtan J. Antibiofilm efficacy of honey and bee-derived defensin-1 on multispecies wound biofilm. J Med Microbiol 2016;65(4):337-44.

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Section: Resultsmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Manuka Honey versus Antibiotic Ear Drops in Healing of Post-Operative Mastoid Cavity: A Prospective Randomized Trial

Damodharan

Verma

Angrup

et al. 2020

Korean J Otorhinolaryngol-Head Neck Surg

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“…The change in the bacteriology may be attributed to new infections occurring postoperatively, either through external auditory canal or Eustachian tube. Carlin et al. (1987) in their study also noted the occurrence of new organisms postoperatively.…”

Section: Discussionmentioning

confidence: 84%

Does preoperative bacterial culture have bearing on healing of mastoid cavity: A prospective study

et al. 2018

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ObjectiveTo study the bacteriological profile in a healing mastoid cavity.MethodsThis study was a single centre prospective study. Culture swabs from granulations in the mastoid cavity were sent in 40 consecutive patients with squamosal chronic otitis media undergoing mastoidectomy. Cultures were processed for both aerobic and anaerobic bacteria.ResultsPreoperatively: specimens from 26 out of 40 (60.5%) had growth on culture, with 22 (55%) showing only one organism while 4 showing multiple organisms. The commonest organism isolated was pseudomonas aeruginosa (n = 15).At 1 month after mastoidctomy, 11 patients had sterile culture while 29 had growth, of which 26 had aerobic growth and 3 had anaerobic growth. Pseudomonas was seen in 22 patients and staphylococcus aureus in 2 patients. The mean Merchant score was 2.At 3 months: 29 patients (72.5%) had sterile culture from mastoid cavity while 11 patients (27.5%) had growth on culture. All positive cultures were aerobic, including pseudomonas (n = 9) and proteus (n = 2). The mean Merchant score was 1.03. Of the 40 patients, 16 (40%) had a different organism cultured postoperatively compared to preoperative swabs.ConclusionPseudomonas and proteus seem to be the most common organisms responsible for persistent otorrhea after mastoidectomy. Persistent sterile otorrhea was seen in 4 patients (10%) in this group at the end of 3 months. Sterile cultures of preoperative swab are more likely to remain sterile in the postoperative period.

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“…20 Bacteria present in the ear pre-operatively were not eliminated and the appearance of organisms postoperatively was not prevented. Carlin et al investigated the use of systemic antibiotic prophylaxis for myringoplasty in 71 patients but failed to demonstrate any benefit from its use.…”

Section: Discussionmentioning

confidence: 99%

“…In the current series, another factor which might have influenced the healing time was the use of prophylactic oral antibiotics. Carlin et al investigated the use of systemic antibiotic prophylaxis for myringoplasty in 71 patients but failed to demonstrate any benefit from its use 20 . Bacteria present in the ear pre-operatively were not eliminated and the appearance of organisms post-operatively was not prevented.…”

Section: Discussionmentioning

confidence: 99%

Early healing and hearing improvement following type one tympanoplasty using the ‘drum sandwich’ technique

Mills

2013

J. Laryngol. Otol.

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Systemic antibiotic prophylaxis and reconstructive ear surgery

Cited by 13 publications

References 12 publications

Manuka Honey versus Antibiotic Ear Drops in Healing of Post-Operative Mastoid Cavity: A Prospective Randomized Trial

Manuka Honey versus Antibiotic Ear Drops in Healing of Post-Operative Mastoid Cavity: A Prospective Randomized Trial

Does preoperative bacterial culture have bearing on healing of mastoid cavity: A prospective study

Early healing and hearing improvement following type one tympanoplasty using the ‘drum sandwich’ technique

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