Systemic and Vascular Inflammation in Patients With Moderate to Severe Psoriasis as Measured by [18F]-Fluorodeoxyglucose Positron Emission Tomography –Computed Tomography (FDG-PET/CT)

Abstract

To evaluate the feasibility of using [18F]fluorodeoxyglucose positron emission tomographycomputed tomography (FDG-PET/CT) to detect and quantify systemic inflammation in patients with psoriasis.Design: Case series with a nested case-control study.Setting: Referral dermatology and preventive cardiology practices.Participants: Six patients with psoriasis affecting more than 10% of their body surface area and 4 controls age and sex matched to 4 of the patients with psoriasis for a nested case-control study. Main Outcome Measures:The FDG uptake in the liver, musculoskeletal structures, and aorta measured by mean standardized uptake value, a measure of FDG tracer uptake by macrophages and other inflammatory cells.Results: FDG-PET/CT identified numerous foci of inflammation in 6 patients with psoriasis within the skin, liver, joints, tendons, and aorta. Inflammation in the joints

Perioperative stroke in a patient undergoing surgery for oral cancer: A case report

“…Atherosclerotic plaque vulnerability represents a crucial target to decrease the probability of plaque rupture and the thrombotic ischemic events that follow (13,14). CT/FDG-PET facilitates highly precise measurements of the inflammatory activity of atherosclerotic plaques (15,16). …”

An Unusual Case of Pulmonary Embolism in a Patient with Psoriasis: Highlighting the Association between Psoriasis and Pulmonary Embolism

“…the skin, but also subclinical inflammation in the liver, joints, tendons and vascular tree even after adjusting for traditional cardiovascular risk factors 6 , suggesting that psoriasis itself predisposes to pro-inflammation pathways independent of traditional risk factors. Others have suggested a more direct hypothesis that psoriasis-initiated skin and systemic inflammation cause insulin resistance, which promotes endothelial cell dysfunction, subsequent atherosclerosis and ultimately thromboembolic events 7 .…”

Psoríase e Doença Cardiovascular: Impacto da Terapêutica com Inibidores do TNF-alfa

“…33, 34 Yiu et al 25 mostraram não existir diferenças significativas entre os IHR de doentes psoriáticos comparativamente ao grupo controlo, tendo-se verificado o mesmo no estudo realizado por Jensen et al 35 Estudos observacionais mostram que a inflamação, detetada por tomografia por emissão de positrões com 18F--fluorodesoxiglicose associada à tomografia computorizada (FDG-PET/CT) nas artérias aorta e carótida, pode ser um preditor futuro de eventos cardiovasculares. [36][37][38] Um estudo recente levado a cabo por Mehta et al 39 permitiu detetar numerosas áreas de inflamação tecidular e vascular, em 6 doentes com psoríase. Os autores compararam ainda a inflamação vascular medida pela FDG-PET/CT em quatro dos seis doentes com psoríase com quatro controlos.…”