Systemic and Regional Hemodynamic Changes during Food Intake and Digestion in Nonanesthetized Dogs

Fronek, K.; Stahlgren, LeRoy H.

doi:10.1161/01.res.23.6.687

Cited by 102 publications

(50 citation statements)

References 6 publications

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“…With respect to the HR change, it was previously reported that in the human and in the dog and sheep, HR increased by about 12-128 % during eating from the preeating value (ABRAMSON and FIERST, 1941;FRONEK and STAHLGREN, 1968;BLAIR-WEST and BROOK, 1969;VATNER et al, 1970a, b;EHRLICH et al, 1972;BLOOM et al, 1975). In our study, the increase in HR during eating was 22 % in the cat.…”

Section: Discussionsupporting

confidence: 57%

Transient responses of heart rate, arterial pressure, and head movement at the beginning of eating in awake cats.

Matsukawa¹,

Ninomiya²

1985

Jpn.J.Physiol

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Time courses of heart rate (HR), arterial pressure (AP), and head movement at the beginning of eating were analyzed in conscious cats. The cats were trained to eat when movements of their body trunks were restrained. Food was presented for 10 sec at intervals of 100 sec. With the abrupt presentation of food, a head-down movement occurred immediately and thereafter eating started with a mean latency of 1.6 sec. During eating HR increased by 22% from the preeating value and AP was elevated by 11 %. To determine the time relation between the onset of eating and the change in each variable in response to eating, mean time courses of HR, AP, and head movement were obtained from 7-40 trials in each cat. The head-down movement preceded the onset of eating by 1.3 sec. The increase in HR preceded the onset of eating by 0.2 sec; the change in AP followed it by 3-4 sec. This indicated that the increase in HR was not induced reflexly either by food intake or by the change in AP. After administration of hexamethonium, the changes in HR and AP in response to eating were abolished, although eating was evoked by the food presentation. Additionally, the increase in HR was also reduced by propranolol and atropine. Thus, the acceleration of HR at the beginning of eating may be induced by central activation of the autonomic nervous system.

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Section: Discussionsupporting

confidence: 57%

Transient responses of heart rate, arterial pressure, and head movement at the beginning of eating in awake cats.

Matsukawa¹,

Ninomiya²

1985

Jpn.J.Physiol

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“…In the study of sheep cited above, BlairWest and Brook (18) not only observed increases in HR and BP similar to those seen in other species (1,4,5,15,17), but also noted the production of copious amounts of saliva. This resulted in a reduction in renal blood flow with the consequent retention of sodium and water, and a reduction in the circulatory volume with a rise in plasma renin concentrations (18).…”

supporting

confidence: 63%

“…Although these alterations occur rapidly and are transitory, they clearly demonstrate that the autonomic nervous system is directly implicated in the cardiovascular adjustments that take place during feeding. In dogs, at the beginning of feeding (1,17), HR and BP rise by 79 and 33%, respectively, compared with control values. In sheep (18), HR and BP increase by 75 and 50%, respectively, when feeding starts.…”

mentioning

confidence: 84%

Cardiovascular responses to locomotor activity and feeding in unrestrained three-toed sloths, Bradypus variegatus

Duarte

Jaguaribe

Pedrosa

et al. 2004

Braz J Med Biol Res

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Heart rate (HR) and systolic (SBP), diastolic (DBP) and mean (MBP) blood pressure were recorded by biotelemetry in nine conscious unrestrained sloths for 1 min every 15 min over a 24-h period. The animals were allowed to freely move in an acoustically isolated and temperature-controlled (24 ± 1ºC) experimental room with light-dark cycle (12/12 h). Behavior was closely monitored through a unidirectional visor and classified as resting (sitting or suspended), feeding (chewing and swallowing embauba leaves, Cecropia adenops), or locomotor activity around the tree trunk or on the room floor. Locomotor activity caused statistically significant increases in SBP (+8%, from 121 ± 22 to 131 ± 18 mmHg), DBP (+7%, from 86 ± 17 to 92 ± 10 mmHg), MBP (+8%, from 97 ± 19 to 105 ± 12 mmHg), and HR (+14%, from 84 ± 15 to 96 ± 15 bpm) compared to resting values, indicating a possible major influence of the autonomic nervous system on the modulation of cardiac function during this behavior. During feeding, the increase in blood pressure was even higher (SBP +27%, from 119 ± 21 to 151 ± 21 mmHg; DBP +21%, from 85 ± 16 to 103 ± 15 mmHg; MBP +24%, from 96 ± 17 to 119 ± 17 mmHg), while HR remained at 14% (from 84 ± 15 to 96 ± 10 bpm) above resting values. The proportionally greater increase in blood pressure than in HR during feeding suggests an increase in peripheral vascular resistance as part of the overall response to this behavior.

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“…A comparison of the calculated hepatic arterial blood concentrations of secretin and pancreozymin with the plasma or serum levels determined in other investigations indicates that a significant reduction in vascular resistance in the liver occurs due to their presence in the systemic arterial circulation following physiological stimuli which provoke their release, as in the small intestine (Fara, Rubinstein & Sonnenschein, 1972;Richardson, 1976). During digestion, secretin and pancreozymin would be released concomitantly; previous reports have demonstrated that mesenteric vasodilatation occurs after eating in dogs (Fronek & Stahlgren, 1968), and in cats, the release of gastrointestinal hormones, particularly secretin and pancreozymin, has been strongly implicated in the mediation of mesenteric vasodilatation resulting from the intraduodenal instillation of fat and other substances (Fara et al, 1972).…”

Section: Discussionmentioning

confidence: 66%

The Effects of Glucagon, Secretin, Pancreozymin and Pentagastrin on the Hepatic Arterial Vascular Bed of the Dog

Richardson

Withrington

1977

British J Pharmacology

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1The sympathetically-innervated arterial vascular bed of the dog's liver was perfused from a femoral artery. Arterial blood flow and perfusion pressure were monitored continuously and the hepatic arterial vascular resistance (HAVR) calculated from these measurements. 2 Commercial preparations of secretin, pancreozymin, glucagon and pentagastrin were administered by intra-arterial (i.a.) injection and infusion. 3 Secretin and pancreozymin by injection caused dose-dependent hepatic arterial vasodilatation, and on a molar basis were both more potent than glucagon or pentagastrin. 4 Intra-arterial infusions of secretin and pancreozymin caused hepatic arterial vasodilatation at calculated blood concentrations close to those measured under physiological conditions by other investigators. The vasodilatation was of the same duration as that of the hormone infusions. 5Pentagastrin by i.a. injection caused dose-dependent hepatic arterial vasodilatation; by i.a. infusion, vasodilatation occurred but there was marked 'escape' from the effects during the continued infusion.6 As reported previously, glucagon by injection caused dose-dependent hepatic arterial vasodilatation of long duration; by infusion, glucagon caused vasodilatation that persisted after the cessation of the infusion. 7 Glucagon infused i.a., inhibited the vasoconstrictor effects of i.a. noradrenaline, over the same range of infusions that caused hepatic arterial vasodilatation. 8 Secretin or pancreozymin did not antagonize the effects of noradrenaline on the hepatic arterial vascular bed at any doses used. 9 Pentagastrin did not antagonize the vasoconstrictor effect of noradrenaline whether hepatic arterial vasodilatation resulted from the pentagastrin infusion, or not. 10 These results are discussed with respect to the possible control of the hepatic arterial vascular bed by gastrointestinal hormones.

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Systemic and Regional Hemodynamic Changes during Food Intake and Digestion in Nonanesthetized Dogs

Cited by 102 publications

References 6 publications

Transient responses of heart rate, arterial pressure, and head movement at the beginning of eating in awake cats.

Transient responses of heart rate, arterial pressure, and head movement at the beginning of eating in awake cats.

Cardiovascular responses to locomotor activity and feeding in unrestrained three-toed sloths, Bradypus variegatus

The Effects of Glucagon, Secretin, Pancreozymin and Pentagastrin on the Hepatic Arterial Vascular Bed of the Dog

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