Systemic and Ocular Comorbidities of Black, Hispanic, and White Women with Cataracts

Kanakamedala, Amritha; Go, Jonathan A.; Wendt, Sydney; Ugoh, Peter; Khan, Mahmood; Al-Mohtaseb, Zaina

doi:10.1089/jwh.2020.8793

Cited by 4 publications

(2 citation statements)

References 20 publications

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“…We plan to investigate the MSO by α-crystallin with genetic mutation of α-crystallin (i.e., αAc-R116C, αAc-R49C, αAc-G98R, αBc-R120G, and αBc-D140N) in our future research. Additionally, all of the donors in this study are Caucasian, but previous studies have shown different races may be at varying levels of risk for the development of cataracts [154,155]; therefore, studying the interactions of α-crystallin in lenses from individuals of different races may be beneficial to gain more insight into the impact race-related risk factors may have on the development of cataracts. Studies involving intrinsic membrane proteins show α-crystallin can bind to intrinsic proteins and affects the lipid interactions of α-crystallin [60,63,156], while other studies show that α-crystallin primarily binds to lipids [31,51,52,56,57,157].…”

Section: Discussionmentioning

confidence: 99%

Association of Alpha-Crystallin with Human Cortical and Nuclear Lens Lipid Membrane Increases with the Grade of Cortical and Nuclear Cataract

Hazen,

Trossi-Torres,

Timsina

et al. 2024

IJMS

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Eye lens α-crystallin has been shown to become increasingly membrane-bound with age and cataract formation; however, to our knowledge, no studies have investigated the membrane interactions of α-crystallin throughout the development of cataracts in separated cortical membrane (CM) and nuclear membrane (NM) from single human lenses. In this study, four pairs of human lenses from age-matched male and female donors and one pair of male lenses ranging in age from 64 to 73 years old (yo) were obtained to investigate the interactions of α-crystallin with the NM and CM throughout the progression of cortical cataract (CC) and nuclear cataract (NC) using the electron paramagnetic resonance spin-labeling method. Donor health history information (diabetes, smoker, hypertension, radiation treatment), sex, and race were included in the data analysis. The right eye lenses CM and NM investigated were 64 yo male (CC: 0), 68 yo male (CC: 3, NC: 2), 73 yo male (CC: 1, NC: 2), 68 yo female (CC: 3, NC: 2), and 73 yo female (CC: 1, NC: 3). Similarly, left eye lenses CM and NM investigated were 64 yo male (CC: 0), 68 yo male (CC: 3, NC: 2), 73 yo male (CC: 2, NC: 3), 68 yo female (CC: 3, NC: 2), and 73 yo female (CC: 1, NC: 3). Analysis of α-crystallin binding to male and female eye lens CM and NM revealed that the percentage of membrane surface occupied (MSO) by α-crystallin increases with increasing grade of CC and NC. The binding of α-crystallin resulted in decreased mobility, increased order, and increased hydrophobicity on the membrane surface in male and female eye lens CM and NM. CM mobility decreased with an increase in cataracts for both males and females, whereas the male lens NM mobility showed no significant change, while female lens NM showed increased mobility with an increase in cataract grade. Our data shows that a 68 yo female donor (long-term smoker, pre-diabetic, and hypertension; grade 3 CC) showed the largest MSO by α-crystallin in CM from both the left and right lens and had the most pronounced mobility changes relative to all other analyzed samples. The variation in cholesterol (Chol) content, size and amount of cholesterol bilayer domains (CBDs), and lipid composition in the CM and NM with age and cataract might result in a variation of membrane surface mobility, membrane surface hydrophobicity, and the interactions of α-crystallin at the surface of each CM and NM. These findings provide insight into the effect of decreased Chol content and the reduced size and amount of CBDs in the cataractous CM and NM with an increased binding of α-crystallin with increased CC and NC grade, which suggests that Chol and CBDs might be a key component in maintaining lens transparency.

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Section: Discussionmentioning

confidence: 99%

Association of Alpha-Crystallin with Human Cortical and Nuclear Lens Lipid Membrane Increases with the Grade of Cortical and Nuclear Cataract

Hazen,

Trossi-Torres,

Timsina

et al. 2024

IJMS

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“…Several other studies have shown that exposure to beta-blockers can also increase cataract formation because it can increase intracellular levels of cyclic adenosine monophosphate, resulting in the modification of lens proteins. 18,19,20 A study by Bautista et al has found that elevated plasma levels of IL-6 and TNF-a occur in patients with hypertension, which is closely associated with an intense systemic inflammation resulting in elevated levels of C-reactive protein, hence triggering cataract development. Hypertension has also been reported to cause a conformational change in the lens capsule, thereby interfering with potassium ion transport in the lens epithelial cells.…”

Section: Prasad Et Al Filho Et Al and LI Et Al Explained That The Pha...mentioning

confidence: 99%

Hubungan Antara Tekanan Intraokular, Diabetes Mellitus, dan Hipertensi dengan Visus Setelah Operasi Fakoemulsifikasi

Sinurat¹,

Christine²,

Adella³

2023

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Introduction: The objective of this study is to determine whether there is a relationship between intraocular pressure (IOP), diabetes mellitus, and hypertension with visual acuity in senile cataract patients after phacoemulsification surgery. Methods: A retrospective cross-sectional study of senile cataract patients who underwent phacoemulsification surgery from 2019-2020 at Christian University of Indonesia General Hospital. Data were taken from medical records using purposive sampling, consist of visual acuity before and after phacoemulsification, visual acuity during 3 months of follow up, IOP before and after phacoemulsification, and the presence of systemic comorbidities such as hypertension and diabetes mellitus. Data were analyzed statistically with SPSS. Result: 122 eyes from 83 patients mostly had severe visual impairment before and a day after phacoemulsification, and improved to normal vision after a month and 3 months following phacoemulsification. The mean IOP was 18,36 mmHg and 21,33 mmHg before and after phacoemulsification. There were 78 patients who had systemic comorbidities such as hypertension and diabetes mellitus. There was no significant correlation between IOP and hypertension with visual acuity after phacoemulsification (p>0,005). Meanwhile, significant correlation was found between diabetes mellitus with visual acuity a day and a month after phacoemulsification (p<0,005). Conclusion: Diabetes mellitus has a significant relationship with visual acuity a day and a month after phacoemulsification surgery.

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Addressing Hearing and Vision Impairment in Long-Term Care: An Important and Often-Neglected Care Priority

Sloane

Whitson

Williams

2021

Journal of the American Medical Directors Association

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Systemic and Ocular Comorbidities of Black, Hispanic, and White Women with Cataracts

Cited by 4 publications

References 20 publications

Association of Alpha-Crystallin with Human Cortical and Nuclear Lens Lipid Membrane Increases with the Grade of Cortical and Nuclear Cataract

Association of Alpha-Crystallin with Human Cortical and Nuclear Lens Lipid Membrane Increases with the Grade of Cortical and Nuclear Cataract

Hubungan Antara Tekanan Intraokular, Diabetes Mellitus, dan Hipertensi dengan Visus Setelah Operasi Fakoemulsifikasi

Addressing Hearing and Vision Impairment in Long-Term Care: An Important and Often-Neglected Care Priority

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