Systemic and local hepcidin as emerging and important peptides in renal homeostasis and pathology

Abstract

Recent data suggest that the importance of hepcidin goes beyond its classical role in controlling systemic iron metabolism. Local hepcidins are emerging as important peptides for organ homeostasis in the brain, heart, blood vessels, and in cancer as well. Similarly, accumulating data indicate that hepcidin does seem to be an important factor in renal homeostasis. This review encompasses present knowledge concerning the role of hepcidin in renoprotection and its use as a biomarker of kidney diseases. Understanding the role of hepcidin in kidneys is important due to its relevance for kidney physiology and its potential therapeutic application in kidney pathologies. © 2018 BioFactors, 45(2):118–134, 2019

Distinctive modulation of hepcidin in cancer and its therapeutic relevance

“…Also, Veuthey et al hypothesized that the proximal tubule produces prohepcidin. However, it should be noted that the authors of this study measured the immunohistochemical expression of this peptide rather than its mRNA expression, which may indicate that the peptide's presence inside proximal tubular cells is caused by absorption from the blood filtrate, which contains the peptide's systemic form (103,104). However, hepcidin expression is not restricted to tubular cells, as there is evidence that it can also be found in the leukocytes of the renal interstitium when the kidney is inflamed (105).…”

“…Hepcidin expression in the kidney is relatively low compared to the liver, which is known to be the ultimate source of hepcidin (8,102). Kulaksiz et al claim that renal hepcidin is primarily found in the connecting tubules and the cortical thick ascending limb of nephron tubules (103). Also, Veuthey et al hypothesized that the proximal tubule produces prohepcidin.…”

“…Kulaksiz et al. claim that renal hepcidin is primarily found in the connecting tubules and the cortical thick ascending limb of nephron tubules ( 103 ). Also, Veuthey et al.…”

Hepcidin and Neutrophil Gelatinase-Associated Lipocalin as a Biomarker for Acute Kidney Injury Linked Iron Metabolism

“…There are multiple damaging mechanisms of cardiac surgery-induced AKI, such as ischemia and reperfusion injury, inflammation, and oxidative stress [4]. Among various candidate biomarkers and underlying mechanisms, hepcidin and iron metabolism in AKI are recently attracting the attention of researchers as one of the main mechanisms causing renal damage in various clinical conditions [5][6][7][8][9]. However, the role of iron regulation in cardiac surgery still remains unclear [8].…”