Systemic and local cocaine increase extracellular serotonin in the nucleus accumbens

Teneud, Luis; Baptista, Trino; Murzi, Euro; Hoebel, Bartley G.; Hernández, Luis

doi:10.1016/0091-3057(95)02087-x

Cited by 43 publications

(27 citation statements)

References 32 publications

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“…Cocaine itself inhibits 5-HT reuptake, and microdialysis studies have shown comparable increases in extracellular levels of 5-HT for cocaine versus the SSRIs, at least over the dose ranges used in the present experiments. For example, 10 mg/kg cocaine elevates extracellular levels of 5-HT in nucleus accumbens by about 200% (Teneud et al 1996;Andrews and Lucki 2001). Fluoxetine (Koch et al 2002;Li et al 2002), sertraline (Sprouse et al 1996), and citalopram (Millan et al 2000) elevate levels of 5-HT to a similar extent.…”

Section: Discussionmentioning

confidence: 95%

Fluoxetine, but not sertraline or citalopram, potentiates the locomotor stimulant effect of cocaine: possible pharmacokinetic effects

et al. 2004

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Fluoxetine enhanced the ability of cocaine to increase locomotor activity. This effect appears not to depend upon increasing 5-HT function since fluoxetine was also effective in rats with substantial 5-HT depletions, and two other SSRIs did not alter the effects of cocaine. Fluoxetine-treated rats had higher brain levels of cocaine than rats treated with cocaine alone. This effect suggests that fluoxetine slows the metabolism of cocaine, perhaps by inhibition of CYP enzymes involved in metabolizing cocaine. The results also indicate that 5-HT reuptake inhibition may not play a prominent role in mediating the stimulant effects of cocaine.

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Section: Discussionmentioning

confidence: 95%

Fluoxetine, but not sertraline or citalopram, potentiates the locomotor stimulant effect of cocaine: possible pharmacokinetic effects

et al. 2004

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“…However, both cocaine and MDMA also increase 5-HT neurotransmission by blocking the 5-HT transporter and by releasing 5-HT from neuronal terminals, respectively (Bradberry et al 1993;Kankaanpaa et al 1998;Ritz and Kuhar 1989;Teneud et al 1996). At least in the case of MDMA, a direct role for increased 5-HT function in mediating locomotor stimulation induced by this drug has been shown (Bankson and Cunningham 2002;Callaway et al 1990;Fletcher et al 2002b;Kehne et al 1996).…”

Section: Introductionmentioning

confidence: 92%

The effects of the 5-HT2C receptor antagonist SB242084 on locomotor activity induced by selective, or mixed, indirect serotonergic and dopaminergic agonists

2006

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SB242084 potentiated the locomotor stimulant effects of both indirect DA and 5-HT agonists. This potentiation may reflect two distinct mechanisms. The first involves direct enhancement of DA activity as shown by potentiation of the effects of amphetamine and methylphenidate. The second mechanism reflects an unmasking of stimulatory 5-HT receptors activated by 5-HT releasers (possibly 5-HT(1B/2A)) through blockade of inhibitory 5-HT(2C) receptors. The failure of SB242084 to potentiate the effect of citalopram might reflect differences between changes in synaptic levels of 5-HT produced by release compared to reuptake inhibition.

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“…Thus, our results, together with the above considerations, indicate that 5-HT 2C receptor antagonists may modulate DA exocytosis also when it is not associated with an increase in DA neuron firing. In addition to its ability to block DA transporter, cocaine is also a potent inhibitor of the 5-HT transporter, thereby increasing 5-HT extracellular levels and reducing 5-HT neuron firing (Cunningham and Lakoski, 1990;Teneud et al, 1996). It is possible that the raise in 5-HT extracellular concentration strengthens the inhibitory tone of 5-HT 2C receptors on DA neuron activity.…”

Section: Discussionmentioning

confidence: 99%

In Vivo Evidence that 5-HT2C Receptor Antagonist but not Agonist Modulates Cocaine-Induced Dopamine Outflow in the Rat Nucleus Accumbens and Striatum

Navailles

Deurwaerdère

Porras

et al. 2003

Neuropsychopharmacol

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During recent years, much attention has been devoted at investigating the modulatory role of central 5-HT 2C receptors on dopamine (DA) neuron activity, and it has been proposed that these receptors modulate selectively DA exocytosis associated with increased firing of DA neurons. In the present study, using in vivo microdialysis in the nucleus accumbens (NAc) and the striatum of halothaneanesthetized rats, we addressed this hypothesis by assessing the ability of 5-HT 2C agents to modulate the increase in DA outflow induced by haloperidol and cocaine, of which the effects on DA outflow are associated or not with an increase in DA neuron firing, respectively. The intraperitoneal administration of cocaine (10-30 mg/kg) induced a dose-dependent increase in DA extracellular levels in the NAc and the striatum. The effect of 15 mg/kg cocaine was potentiated by the mixed 5-HT 2C/2B antagonist SB 206553 (5 mg/kg i.p.) and the selective 5-HT 2C antagonist SB 242084 (1 mg/kg i.p.) in both brain regions. The mixed 5-HT 2C/2B agonist, Ro 60-0175 (1 mg/kg i.p.), failed to affect cocaine-induced DA outflow, but reduced significantly the increase in DA outflow induced by the subcutaneous administration of 0.1 mg/kg haloperidol. The obtained results provide evidence that 5-HT 2C receptors exert similar effects in both the NAc and the striatum, and they modulate DA exocytosis also when its increase occurs independently from an increase in DA neuron impulse activity. Furthermore, they show that 5-HT 2C agonists, at variance with 5-HT 2C antagonists, exert a preferential control on the impulse-stimulated release of DA.

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Systemic and local cocaine increase extracellular serotonin in the nucleus accumbens

Cited by 43 publications

References 32 publications

Fluoxetine, but not sertraline or citalopram, potentiates the locomotor stimulant effect of cocaine: possible pharmacokinetic effects

Fluoxetine, but not sertraline or citalopram, potentiates the locomotor stimulant effect of cocaine: possible pharmacokinetic effects

The effects of the 5-HT2C receptor antagonist SB242084 on locomotor activity induced by selective, or mixed, indirect serotonergic and dopaminergic agonists

In Vivo Evidence that 5-HT2C Receptor Antagonist but not Agonist Modulates Cocaine-Induced Dopamine Outflow in the Rat Nucleus Accumbens and Striatum

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