Systemic and forearm vascular resistance changes after upright bicycle exercise in man.

Coats, Andrew J.S.; Conway, James; Isea, Jesús; Pannarale, Giuseppe; Sleight, Peter; Somers, Virend K.

doi:10.1113/jphysiol.1989.sp017654

Cited by 91 publications

(98 citation statements)

References 23 publications

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“…This may be due to other compensatory mechanisms, such as the baroreflex, that are activated in normotensive subjects, and prevent the degree of PEH from affecting orthostatic tolerance. Although there are reports of gender differences in blood pressure 17 and sympathetic nerve activity, 18 PEH appears to be unaffected by gender, since gender specific 19,20 and mixed gender studies 15,[21][22][23] have found similar degrees of hypotension. It also occurs independent of age, having been observed in young 24,25 middle aged 25 and older adults.…”

Section: Does Peh Occur In All Individuals?mentioning

confidence: 90%

“…In those studies that have observed a decline in blood pressure following exercise, the average decrement in pressure was approximately 8/9 (SBP/DBP) mm Hg in the normotensive population, 16,[20][21][22][23]25,[31][32][33][34][35] 14/9 mm Hg in the borderline hypertensive population [10][11][12]34,[36][37][38][39] and 10/7 mm Hg in the hypertensive population. 13 37 We recently examined the effects of the exercising muscle mass by comparing the PEH response to both leg and arm ergometry at the same relative intensity.…”

Section: Magnitude Of the Blood Pressure Declinementioning

confidence: 99%

“…10,11,19,22,24,[31][32][33]35,41,[43][44][45][59][60][61]63,71,72 Treadmill exercise at similar intensities has also been documented to elicit PEH. 14,15,20,25,34,40,[55][56][57][58] Direct comparisons of the effect of exercise intensity have, for the most part, found that PEH occurs independent of exercise intensity.…”

Section: Intensity Of the Exercisementioning

confidence: 99%

“…9,16,31,44,49,57,61 Most studies have measured blood pressure for only 1-2 h following exercise 12,13,16,20,22,23,25,34,[36][37][38][39]55,58,75 and the majority of these have found a nadir in blood pressure during that time with a return or trend towards baseline pressure at the cessation of measurement.…”

Section: Duration Of the Responsementioning

confidence: 99%

“…13,15,57 In all such instances the decrements were found to be due to reductions in stroke volume. In humans, it is common to observe an increased heart rate during some or all of the hypotensive period, 20,22,33,35,58,63,77 whereas rodents often display decreased or unchanged heart rates. 30,[48][49][50]54 Of interest is that, with the exception of one study, 43 changes in human cardiac output post exercise appear dependent on the initial state of hypertension.…”

Section: Cardiac Output (Q · C)mentioning

confidence: 99%

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Potential causes, mechanisms, and implications of post exercise hypotension

2002

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Post exercise hypotension (PEH) is a phenomenon of a prolonged decrease in resting blood pressure in the minutes and hours following acute exercise. Knowledge of PEH is potentially useful in designing first line strategies against hypertension as well as allowing a further understanding of blood pressure regulation in both Keywords: blood pressure; vascular; cardiac; opioids; exercise Blood pressure responses during exerciseDuring dynamic exercise, cardiac output increases dramatically to ensure adequate perfusion to the working musculature. This increase is achieved by a withdrawal of parasympathetic tone (causing an increased heart rate and contractility), an increase in sympathetic activity (directly and indirectly increasing heart rate and contractility) and pronounced vasoconstriction of the venous vasculature (causing a greater venous return and therefore stroke volume). In parallel, the need for increased blood flow and oxygen delivery to the exercising muscle is achieved through regional vasodilation of those arterioles supplying blood to the exercising tissue in combination with a vasoconstriction of arterioles, which perfuse non-essential tissues. Although the mechanism of vasodilation at the onset of exercise is not fully understood, many compounds (eg, potassium, adenosine, nitric oxide, etc) have been implicated in the exercise induced changes. Contraction of the active muscle mass also assists in returning blood towards the heart. This 'muscle pump' effect further increases venous return and stroke volume.Increased cardiac output and vasoconstriction in non-exercising vascular beds increases systolic blood pressure (SBP), but the significant vasodilation at the exercising muscle beds helps to buffer this increase and results in a minimal rise in diastolic blood pressure (DBP). As exercise continues Correspondence: JR MacDonald, McMaster University Medical Centre, Room 4U18, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada. E-mail: jaymacȰmcmaster.ca health and disease. Following a brief review of blood pressure responses to exercise, this paper will provide a current and comprehensive summary of PEH and integrate the current state of knowledge surrounding it.

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Section: Does Peh Occur In All Individuals?mentioning

confidence: 90%

Section: Magnitude Of the Blood Pressure Declinementioning

confidence: 99%

Section: Intensity Of the Exercisementioning

confidence: 99%

Section: Duration Of the Responsementioning

confidence: 99%

Section: Cardiac Output (Q · C)mentioning

confidence: 99%

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Potential causes, mechanisms, and implications of post exercise hypotension

2002

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Baroreceptors and Hypertension

Sleight

1991

Baroreceptor Reflexes

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Book ReviewsBaroreceptors and Hypertension : Proceedings of an International Symposium November, 1965, Edited by P. Kezdi, Pergamon Press 1967, 460 pages, 105^. or US SI6.This book records the proceedings of a two-day symposium held in Dayton, Ohio, in November, 1965, and attended by some fifty experts in this field, drawn from the USA and many European countries. For a book of this kind, the delay in publication seems unduly long. As a factual report of the communi-

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Sciatic nerve stimulation induces hypotension but not renal or lumbar sympathoinhibition in hypertensive Dahl rats

Kenney

Morgan

1993

Clinical Autonomic Research

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Sustained reductions in arterial pressure and sympathetic nerve activity occur after prolonged sciatic nerve stimulation in spontaneously hypertensive and pre-hypertensive Dahl salt-sensitive rats whereas these responses are not observed in renal hypertensive or Dahl resistant rats. These observations suggest that the development of post-stimulation hypotension and sympathoinhibition may be related to the genetic predisposition for hypertension rather than to the increased level of arterial pressure. However, it is not known whether the magnitude of the post-stimulation blood pressure and sympathetic nerve responses are influenced by the increased level of arterial pressure in addition to the genetic predisposition to hypertension. In the present study, we sought to determine if sustained sciatic nerve stimulation induces post-stimulation hypotension in hypertensive Dahl sensitive (DS) rats. For this purpose, mean arterial pressure (MAP), heart rate (HR), renal (RSNA) and lumbar (LSNA) sympathetic nerve activity were recorded during and after sciatic nerve stimulation in hypertensive DS rats (n = 17) fed an 8.0% NaCl diet for 7-8 weeks. Sciatic nerve stimulation increased HR (control, 443 +/- 10 b.p.m.; stimulation, 487 +/- 8 b.p.m.; p < 0.05) and tended to increase MAP, RSNA and LSNA. Two hours after stimulation, MAP was reduced (control 145 +/- 5 mmHg; recovery, 124 +/- 8 mmHg; p < 0.01) from control values. In contrast, RSNA and HR remained unchanged whereas LSNA was increased (69 +/- 20%; p < 0.05) from control values 120 min after stimulation. MAP, HR and RSNA were unchanged from control values during and for 2 h after sham stimulation in eight DS rats.(ABSTRACT TRUNCATED AT 250 WORDS)

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Systemic and forearm vascular resistance changes after upright bicycle exercise in man.

Cited by 91 publications

References 23 publications

Potential causes, mechanisms, and implications of post exercise hypotension

Potential causes, mechanisms, and implications of post exercise hypotension

Baroreceptors and Hypertension

Sciatic nerve stimulation induces hypotension but not renal or lumbar sympathoinhibition in hypertensive Dahl rats

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