Systemic amyloidosis with amyloid goiter: An autopsy report

Kawai, Chihiro; Miyao, Masashi; Kotani, Hirokazu; Minami, Hirozo; Abiru, Hitoshi; Hamayasu, Hideki; Yamamoto, A.; Tamaki, Keiji

doi:10.1016/j.legalmed.2022.102167

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…Forensic pathologists have utilized different variations in HSPs under diverse stressors (including hypoxia, and thermal stress), designating HSP27 and HSP70 as target proteins for the postmortem diagnosis of heat stroke, death in fire, and hypothermia (Table 1). Specific IHC stains can also help forensic pathologists to determine the final cause of death when they encounter sudden death in patients with systematic immune disorders [40]. With the application of IHC in complex forensic judicial autopsies, more and more cases achieve a precise diagnosis of the cause of death.…”

Section: Immunohistochemistry (Ihc) Assaymentioning

confidence: 99%

The Role of Protein Degradation in Estimation Postmortem Interval and Confirmation of Cause of Death in Forensic Pathology: A Literature Review

Huang,

Zhao,

Liu

et al. 2024

IJMS

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It is well known that proteins are important bio-macromolecules in human organisms, and numerous proteins are widely used in the clinical practice, whereas their application in forensic science is currently limited. This limitation is mainly attributed to the postmortem degradation of targeted proteins, which can significantly impact final conclusions. In the last decade, numerous methods have been established to detect the protein from a forensic perspective, and some of the postmortem proteins have been applied in forensic practice. To better understand the emerging issues and challenges in postmortem proteins, we have reviewed the current application of protein technologies at postmortem in forensic practice. Meanwhile, we discuss the application of proteins in identifying the cause of death, and postmortem interval (PMI). Finally, we highlight the interpretability and limitations of postmortem protein challenges. We believe that utilizing the multi-omics method can enhance the comprehensiveness of applying proteins in forensic practice.

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Section: Immunohistochemistry (Ihc) Assaymentioning

confidence: 99%

The Role of Protein Degradation in Estimation Postmortem Interval and Confirmation of Cause of Death in Forensic Pathology: A Literature Review

Huang,

Zhao,

Liu

et al. 2024

IJMS

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Amyloid Goiter Secondary to Behcet's Disease: A Case Report and Literature Review

Khader,

Abed,

Rabee

et al. 2023

Cureus

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Amyloid deposition in the thyroid gland is a common presentation, yet amyloid goiter remains relatively rare. Proper differentiation of this condition from other goiter types and malignancies is essential. Although amyloid extensively invades the thyroid gland, patients are usually euthyroid, and many different presentations may occur. We report a case of a 42-year-old male patient who was diagnosed with secondary amyloidosis due to Behcet's disease. He presented with clinical manifestations of hyperthyroidism and systemic amyloidosis complicated by chronic kidney disease, which is the first case of such an entity to be reported in Palestine.

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Systemic amyloidosis with amyloid goiter: An autopsy report

Cited by 2 publications

References 19 publications

The Role of Protein Degradation in Estimation Postmortem Interval and Confirmation of Cause of Death in Forensic Pathology: A Literature Review

The Role of Protein Degradation in Estimation Postmortem Interval and Confirmation of Cause of Death in Forensic Pathology: A Literature Review

Amyloid Goiter Secondary to Behcet's Disease: A Case Report and Literature Review

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