Systemic adverse effects of topical ocular treatments

Labétoulle, Marc; Frau, E; Jeunne, Claire Le

doi:10.1016/s0755-4982(05)83987-9

Cited by 45 publications

(36 citation statements)

References 45 publications

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“…Side effects can possibly be severe [19]. Most side effects that were registered concerning glaucoma medications in the present study are reversible.…”

Section: Discussionmentioning

confidence: 47%

Side effects of commonly used glaucoma medications: comparison of tolerability, chance of discontinuation, and patient satisfaction

Beckers

Schouten

Webers

et al. 2008

Graefes Arch Clin Exp Ophthalmol

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Background To compare the tolerability of commonly prescribed topical glaucoma medications by determining frequency and bother of side effects, patient satisfaction with their medication, and the chance of discontinuation of eye drops. Methods The tolerability of topical glaucoma medication was studied in glaucoma patients from nine hospitals. The frequency and severity of side effects was investigated together with patient satisfaction with the medication and the probability to change medication due to reported side effects. To register side effects of topical glaucoma medication, patients were requested to fill in a questionnaire based on "the Comparison of Ophthalmic Medications for Tolerability" (COMTOL) questionnaire supplemented with items based on the most frequently observed and severe side effects.Results The number of patients responding was 3,333 (87%). Most patients (79%) were satisfied with their eye medication. The median score for ocular side effects was 58 on a scale ranging from 0 to 320. The probability that medication would be changed by the ophthalmologist at the next visit due to reported side effects occurring since the patients' last or last but one visit to the ophthalmologist was 9%. The most frequently prescribed drugs were timolol, latanoprost, and the fixed combinations of dorzolamide/ timolol (Cosopt®) and latanoprost/timolol (Xalcom®). Only small differences in tolerability were found between these drugs. Conclusions The tolerability of timolol, latanoprost, and the fixed combinations of latanoprost/timolol (Xalcom®) and dorzolamide/timolol (Cosopt®) seem to be comparable. Patients are satisfied with their glaucoma medication and have a low chance of discontinuation of eye drops due to side effects.

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“…Side effects can possibly be severe [19]. Most side effects that were registered concerning glaucoma medications in the present study are reversible.…”

Section: Discussionmentioning

confidence: 47%

Side effects of commonly used glaucoma medications: comparison of tolerability, chance of discontinuation, and patient satisfaction

Beckers

Schouten

Webers

et al. 2008

Graefes Arch Clin Exp Ophthalmol

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“…1.9 mM. This high concentration of ophthalmic drugs in eye drops has been attributed to their poor permeability across the corneal epithelium, as only 1-5% of the active drug reportedly penetrates the eye [54,55]. The nanoparticle-loaded pHEMA contact lens released a maximum of 48 μg of DXP.…”

Section: Synthesis and Characterization Of Nanoparticle-laden Phema Cmentioning

confidence: 99%

Synthesis and Characterization of Poly(2-hydroxyethylmethacrylate) Contact Lenses Containing Chitosan Nanoparticles as an Ocular Delivery System for Dexamethasone Sodium Phosphate

et al. 2016

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“…Atropine or atropinelike drugs are competitor antagonists of acetylcholine that interact with muscarinic receptors. Cases of anticholinergic poisoning following the administration of topical eye drops containing atropine or atropine-like substances have been previously reported (1,(3)(4)(5). When a patient has nonreactive dilated pupils, tachycardia, flushed skin, dry mucosa, hyperthermia, urinary retention, and changes in consciousness, anticholinergic poisoning should be considered (3,4,6).…”

Section: Discussionmentioning

confidence: 99%

Uncontrolled Agitation and Flushed Face Due to Tropicamide: A Missed Diagnosis

Özkaya¹,

Gökay²,

Kendir³

et al. 2017

J Emerg Med Case Rep

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Introduction: Topical ophthalmic drugs that are not used in appropriate doses may lead to overdose symptoms. Case Report: A 2-month-old boy presented to the emergency department with extreme agitation, flushed face, mydriasis, cataract in the left eye, dry oral mucosa, spasticity in all extremities, and wheezing. It was learned that the patient had been receiving eye drops containing tropicamide at repeated doses before ophthalmologic evaluation. Pheniramine maleate and methylprednisolone were given to counter the drug-related side-effects or allergic reactions to the eye drop. At the follow-up, his symptoms and findings had become exacerbated, and he was admitted to the pediatric intensive care unit due to shock and drug-related anticholinergic toxicity. Conclusion: This case illustrates the importance of recognizing toxidromes at differential diagnosis and is the first reported pediatric case with tropicamide-induced anticholinergic syndrome.

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Systemic adverse effects of topical ocular treatments

Cited by 45 publications

References 45 publications

Side effects of commonly used glaucoma medications: comparison of tolerability, chance of discontinuation, and patient satisfaction

Side effects of commonly used glaucoma medications: comparison of tolerability, chance of discontinuation, and patient satisfaction

Synthesis and Characterization of Poly(2-hydroxyethylmethacrylate) Contact Lenses Containing Chitosan Nanoparticles as an Ocular Delivery System for Dexamethasone Sodium Phosphate

Uncontrolled Agitation and Flushed Face Due to Tropicamide: A Missed Diagnosis

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