Systemic administration of vitamins C and E attenuates nociception induced by chronic constriction injury of the sciatic nerve in rats

Riffel, Alessandro; Souza, Jéssica Araújo de; Santos, Maria do Carmo Quevedo; Horst, Andréa; Scheid, Taina; Kolberg, Carolina; Belló‐Klein, Adriane; Partata, Wania Aparecida

doi:10.1016/j.brainresbull.2016.02.004

Cited by 33 publications

(28 citation statements)

References 40 publications

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“…GSH is a protective agent and detoxifies reactive oxygen species (ROS) both enzymatically and non-enzymatically ( 12 ). NAC has also a direct role in scavenging ROS in neurons ( 6 ), which seems to help normalize the oxidative status altered by neuropathic pain, because ROS such as superoxide radicals, hydrogen peroxide (H 2 O 2 ) and nitric oxide play an important role in the pathogenesis of neuropathic pain ( 8 , 9 , 10 , 13 ). In rats with CCI, NAC treatment reduced nitric oxide metabolites and increased the activity of antioxidant enzymes such as glutathione-S-transferase and glutathione peroxidase in the spinal cord ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

“…Since neuropathic pain increases ROS ( 8 , 9 , 10 , 13 ) and NAC is a precursor of GSH ( 4 , 5 ), we postulated that NAC treatment would change the levels of lipid hydroperoxides and ascorbic acid in the lumbosacral spinal cord from CCI rats, the region where most afferent fibers of the sciatic nerve enter. Thus, our study assessed the effect of intraperitoneal administration of NAC (150 mg·kg −1 ·day −1 ), given for 1, 3, and 7, days, on the lipid hydroperoxide and ascorbic acid levels in the lumbosacral spinal cord of rats with CCI.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, our study assessed the effect of intraperitoneal administration of NAC (150 mg·kg −1 ·day −1 ), given for 1, 3, and 7, days, on the lipid hydroperoxide and ascorbic acid levels in the lumbosacral spinal cord of rats with CCI. Since oxidative stress has also been determined by the measurements of a decrease in total antioxidant capacity (TAC) ( 13 ), we also assessed this parameter in the spinal cord of the rats with CCI. This measurement is important because NAC has an antioxidant action as discussed above.…”

Section: Introductionmentioning

confidence: 99%

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Effects of N-acetylcysteine on spinal cord oxidative stress biomarkers in rats with neuropathic pain

Horst

Souza

Santos

et al. 2017

Braz J Med Biol Res

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N-acetylcysteine (NAC) inhibits nociceptive transmission. This effect has been associated partly with its antioxidant properties. However, the effect of NAC on the levels of lipid hydroperoxides (a pro-oxidant marker), content of ascorbic acid (a key antioxidant molecule of nervous tissue) and total antioxidant capacity (TAC) is unknown. Thus, our study assessed these parameters in the lumbosacral spinal cord of rats with chronic constriction injury (CCI) of the sciatic nerve, one of the most commonly employed animal models of neuropathic pain. Thirty-six male Wistar rats weighing 200–300 g were equally divided into the following groups: Naive (rats did not undergo surgical manipulation); Sham (rats in which all surgical procedures involved in CCI were used except the ligature), and CCI (rats in which four ligatures were tied loosely around the right common sciatic nerve). All rats received intraperitoneal injections of NAC (150 mg·kg−1·day−1) or saline for 1, 3, or 7 days. Rats were killed 1, 3, and 7 days after surgery. NAC treatment prevented the CCI-induced increase in lipid hydroperoxide levels only at day 1, although the amount was higher than that found in naive rats. NAC treatment also prevented the CCI-induced increase in ascorbic acid content, which occurred at days 1, 3, and 7. No significant change was found in TAC with NAC treatment. The changes observed here may be related to the antinociceptive effect of NAC because modulation of oxidative-stress parameters seemed to help normalize the spinal cord oxidative status altered by pain.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of N-acetylcysteine on spinal cord oxidative stress biomarkers in rats with neuropathic pain

Horst

Souza

Santos

et al. 2017

Braz J Med Biol Res

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“…However, there is considerable divergence in the literature regarding the length of this period. It can vary from 3 days in a sciatic nerve constriction model (Riffel et al, ), to a period between 4 and 8 weeks for an infraorbital constriction model by the technique proposed by Kernisant (Kernisant, Gear, Jasmin, Vit, & Ohara, ). A similar result was found by Vos and colleagues (Vos et al, ) using an infraorbital nerve constriction model, which demonstrated a significant increase in response to mechanical stimulation by von Frey test filaments from the 12th to 15th days after surgery.…”

Section: Discussionmentioning

confidence: 99%

Transcranial direct current stimulation (tDCS) and trigeminal pain: A preclinical study

et al. 2019

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Objective Our objective was to evaluate the Transcranial direct current stimulation (tDCS) effect on facial allodynia induced by chronic constriction of the infraorbital nerve (CCI‐ION) and on the brainstem levels of TNF‐α, NGF, IL‐10, and serum LDH in rats. Methods Rats were exposed to the CCI‐ION model. Facial allodynia was assessed by von Frey filaments test at baseline, 3, 7, 10, and 14 days postsurgery and 24 hr and 7 days after the bimodal tDCS sessions for 20 min/day/8 days. Results Chronic constriction of the infraorbital nerve induced a significant decrease in the mechanical threshold 14 days after surgery. This effect was reversed by tDCS treatment, with the mechanical threshold returning to basal levels at 24 hr after the end of the treatment and it persisted for 7 days after the end of the treatment. tDCS also decreased LDH serum levels compared to those in the control group. There was an interaction between pain and treatment with respect to brainstem levels of NGF, TNF‐α, and IL‐10. Conclusion Chronic constriction of the infraorbital nerve model was effective in establishing trigeminal neuropathic pain on 14 days after surgery, and tDCS reduced allodynia and LDH serum levels and promoted alterations in NGF, TNF‐α, and IL‐10 brainstem levels. Thus, we suggest that tDCS may be a potential therapy in the trigeminal pain treatment.

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“…[6] In addition to its outstanding antioxidant activity, VE can prevent cardiovascular diseases and cancers, as well as it can exert antinociceptive action. [7][8][9][10] Another subject of interest in VE research is the neuroprotection since it had an effect on the survival of Purkinje neurons, neuroglial activation and excitotoxicity models, cytoprotection and inflammatory pathways of the neuroglia. This neuroprotective function was also mentioned to explain the alleged relationship between an optimal VE status and the reduced risk of mild cognitive impairment and Alzheimer's disease.…”

Section: Introductionmentioning

confidence: 99%

The efficacy of microemulsion-based delivery to improve vitamin E properties: evaluation of the antinociceptive, antioxidant, antidepressant- and anxiolytic-like activities in mice

Wilhelm

Vogt

Reis

et al. 2018

Journal of Pharmacy and Pharmacology

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Objectives A microemulsion‐based delivery system was designed to improve vitamin E (VE) properties, and its antinociceptive, antioxidant, antidepressant‐ and anxiolytic‐like activities in mice were evaluated. Methods Male Swiss mice received, by intragastric route, canola oil (20 ml/kg), blank microemulsion (B‐ME) (20 ml/kg), VE free (VE‐F) (200 mg/kg) or VE microemulsion (VE‐ME) (200 mg/kg). In acute treatment, a single dose of treatments was administrated and 30 min after behavioural tests were performed. In the subchronic treatment, mice received such treatments, once a day, for 8 days. On the eighth day, behavioural tests were performed. Key findings In the subchronic treatment, VE‐ME increased entries and spent time in the open arms in the elevated plus‐maze test and decreased the immobility time in the tail suspension test, but no change was found after acute treatment. Acute and subchronic treatments with VE‐ME increased response latency to thermal stimulus in the hot‐plate test. VE‐ME decreased the thiobarbituric acid reactive species levels in the acute and subchronic protocols. Additionally, in subchronic treatment, VE‐ME increased renal catalase activity, but VE‐F reduced its activity. Conclusions Vitamin E‐microemulsions showed antioxidant, antinociceptive, antidepressant‐ and anxiolytic‐like actions; thus, ME‐based delivery improved pharmacological properties of VE.

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Systemic administration of vitamins C and E attenuates nociception induced by chronic constriction injury of the sciatic nerve in rats

Cited by 33 publications

References 40 publications

Effects of N-acetylcysteine on spinal cord oxidative stress biomarkers in rats with neuropathic pain

Effects of N-acetylcysteine on spinal cord oxidative stress biomarkers in rats with neuropathic pain

Transcranial direct current stimulation (tDCS) and trigeminal pain: A preclinical study

The efficacy of microemulsion-based delivery to improve vitamin E properties: evaluation of the antinociceptive, antioxidant, antidepressant- and anxiolytic-like activities in mice

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