Systematical analysis of underlying markers associated with Marfan syndrome via integrated bioinformatics and machine learning strategies

Wang, Guohua; Liu, Chunjiang; Wu, Qianyun; Wang, Jiajia; Tang, Xiaoqi; Wu, Zhifeng; Tang, Liming; Zhou, Yufei

doi:10.1080/07391102.2023.2233021

Cited by 1 publication

(1 citation statement)

References 40 publications

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“…The presence of bacteria associated with chicken meat spoilage and storage conditions was analyzed by several authors, and associations between different genera ( Acinetobacter , Brochothrix , Thermosphacta , Flavobacterium , Photobacterium , Pseudomonas , Psychrobacter ) were found [ 90 , 91 , 97 ]. Some companies are offering services [ 98 , 99 , 100 ] in this area, such as Clear Labs, a business providing fully automated NGS platforms ( accessed on 24 November 2023). The Clear Safety Salmonella test has been approved by the National Poultry Improvement Plan (NPIP) for interim use in the detection of Salmonella.…”

Section: Direct Short and Long-read Sequencing For Applications Not R...mentioning

confidence: 99%

Next-Generation Sequencing for the Detection of Microbial Agents in Avian Clinical Samples

Afonso,

Afonso

2023

Veterinary Sciences

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Direct-targeted next-generation sequencing (tNGS), with its undoubtedly superior diagnostic capacity over real-time PCR (RT-PCR), and direct-non-targeted NGS (ntNGS), with its higher capacity to identify and characterize multiple agents, are both likely to become diagnostic methods of choice in the future. tNGS is a rapid and sensitive method for precise characterization of suspected agents. ntNGS, also known as agnostic diagnosis, does not require a hypothesis and has been used to identify unsuspected infections in clinical samples. Implemented in the form of multiplexed total DNA metagenomics or as total RNA sequencing, the approach produces comprehensive and actionable reports that allow semi-quantitative identification of most of the agents present in respiratory, cloacal, and tissue samples. The diagnostic benefits of the use of direct tNGS and ntNGS are high specificity, compatibility with different types of clinical samples (fresh, frozen, FTA cards, and paraffin-embedded), production of nearly complete infection profiles (viruses, bacteria, fungus, and parasites), production of “semi-quantitative” information, direct agent genotyping, and infectious agent mutational information. The achievements of NGS in terms of diagnosing poultry problems are described here, along with future applications. Multiplexing, development of standard operating procedures, robotics, sequencing kits, automated bioinformatics, cloud computing, and artificial intelligence (AI) are disciplines converging toward the use of this technology for active surveillance in poultry farms. Other advances in human and veterinary NGS sequencing are likely to be adaptable to avian species in the future.

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Section: Direct Short and Long-read Sequencing For Applications Not R...mentioning

confidence: 99%

Next-Generation Sequencing for the Detection of Microbial Agents in Avian Clinical Samples

Afonso,

Afonso

2023

Veterinary Sciences

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show abstract

Systematical analysis of underlying markers associated with Marfan syndrome via integrated bioinformatics and machine learning strategies

Cited by 1 publication

References 40 publications

Next-Generation Sequencing for the Detection of Microbial Agents in Avian Clinical Samples

Next-Generation Sequencing for the Detection of Microbial Agents in Avian Clinical Samples

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