Systematic Transcriptional Profiling of Responses to STAT1- and STAT3-Activating Cytokines in Different Cancer Types

Kirchmeyer, Mélanie; Servais, Florence; Ginolhac, Aurélien; Nazarov, Petr V.; Margue, Christiane; Philippidou, Demetra; Nicot, Nathalie; Behrmann, Iris; Haan, Claude; Kreis, Stephanie

doi:10.1016/j.jmb.2020.09.011

Cited by 5 publications

(4 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…STAT1, EGFR, ESR1 and TP53 have all been shown to be important for the progression of liver cancer, along with the STAT3 signalling pathway. 68 , 69 , 70 , 71 , 72 , 73 , 74 Notably, two clinical trials, a phase III trial on tamoxifen (an ESR1 antagonist) and a phase II trial of tamoxifen in combination with cisplatin and doxorubicin hydrochloride, have already been performed for the treatment of liver cancers. 75 , 76 The postulated central role of the estrogen receptor should be further investigated to address whether both classes of estrogen receptors (ERα and ERβ) are involved and relevant in hepatocellular carcinoma progression.…”

Section: Resultsmentioning

confidence: 99%

“…These four proteins have the largest influence in the STAT interactome in liver cancer with STAT3 following closely behind. STAT1, EGFR, ESR1 and TP53 have all been shown to be important for the progression of liver cancer, along with the STAT3 signalling pathway 68–74 . Notably, two clinical trials, a phase III trial on tamoxifen (an ESR1 antagonist) and a phase II trial of tamoxifen in combination with cisplatin and doxorubicin hydrochloride, have already been performed for the treatment of liver cancers 75,76 .…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

JAK‐STAT core cancer pathway: An integrative cancer interactome analysis

Erdogan

Radu

Orlova

et al. 2022

J Cellular Molecular Medi

View full text Add to dashboard Cite

Through a comprehensive review and in silico analysis of reported data on STATlinked diseases, we analysed the communication pathways and interactome of the seven STATs in major cancer categories and proposed rational targeting approaches for therapeutic intervention to disrupt critical pathways and addictions to hyperactive JAK/STAT in neoplastic states. Although all STATs follow a similar molecular activation pathway, STAT1, STAT2, STAT4 and STAT6 exert specific biological profiles associated with a more restricted pattern of activation by cytokines. STAT3 and STAT5A as well as STAT5B have pleiotropic roles in the body and can act as critical oncogenes that promote many processes involved in cancer development. STAT1, STAT3 and STAT5 also possess tumour suppressive action in certain mutational and cancer type context. Here, we demonstrated member-specific STAT activity in major cancer types. Through systems biology approaches, we found surprising roles for EGFR family members, sex steroid hormone receptor ESR1 interplay with oncogenic STAT function and proposed new drug targeting approaches of oncogenic STAT pathway addiction.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

JAK‐STAT core cancer pathway: An integrative cancer interactome analysis

Erdogan

Radu

Orlova

et al. 2022

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

“…As any abnormality or change in signal regulatory factors can lead to tumor formation, the role of STAT1 in the occurrence and development of tumors requires further study. There is evidence that STAT1 may play a dual role in this regard (8,26). Specifically, while there is some evidence that STAT1 can induce tumorigenesis, accumulating evidence has shown that STAT1 is a tumor suppressor, exerting its anti-tumor role by interfering with the tumor microenvironment and/or signaling pathway (7,26,27).…”

Section: Discussionmentioning

confidence: 99%

“…In this way, signal transducer and activator of transcription 1 (STAT1) can play an essential role in signal transduction induced by many cytokines (6). STAT1 is mainly involved in antiviral and antibacterial reactions, inhibits tumor growth, and induces cell apoptosis by regulating antiapoptotic genes such as Bcl-XL, caspases, and Bax (7,8). Research has shown that abnormalities in 12 signaling pathways mainly relate to the occurrence and development of cancer, with the JAK/STAT1 signaling pathway being one of these pathways (9).…”

Section: Introductionmentioning

confidence: 99%