Systematic Studies on the Paracellular Permeation of Model Permeants and Oligonucleotides in the Rat Small Intestine with Chenodeoxycholate as Enhancer

Tsutsumi, Keiko; Li, S.Kevin; Hymas, R.V.; Teng, Ching‐Leou; Tillman, Lloyd; Hardee, Gregory E.; Higuchi, William I.; Ho, Norman F.H.

doi:10.1002/jps.21093

Cited by 27 publications

(17 citation statements)

References 36 publications

(40 reference statements)

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“…This is achieved through the process of restitution, whereby neighboring epithelial cells rapidly migrate into denuded areas, thereby restoring barrier integrity. It was also proposed that, although prolonged increases in luminal bile acids can be detrimental because of enhanced epithelial permeability, transient permeability changes that occur upon acute exposure may be useful in augmenting delivery of hydrophilic drugs to the intestine [28].…”

Section: Epithelial Barrier Functionmentioning

confidence: 99%

Bile acids in regulation of intestinal physiology

Keating¹,

Keely

2009

Curr Gastroenterol Rep

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In addition to their roles in facilitating lipid digestion and absorption, bile acids are recognized as important regulators of intestinal function. Exposure to bile acids can dramatically influence intestinal transport and barrier properties; in recent years, they have also become appreciated as important factors in regulating cell growth and survival. Indeed, few cells reside within the intestinal mucosa that are not altered to some degree by exposure to bile acids. The past decade saw great advances in the knowledge of how bile acids exert their actions at the cellular and molecular levels. In this review, we summarize the current understanding of the role of bile acids in regulation of intestinal physiology.

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Section: Epithelial Barrier Functionmentioning

confidence: 99%

Bile acids in regulation of intestinal physiology

Keating¹,

Keely

2009

Curr Gastroenterol Rep

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“…Conversely, diarrhea without steatorrhea benefits from treatment with ion exchange www.wjgnet.com resins such as cholestiramine that bind and act as sequestrant of BAs during their intestinal transit [137] . Moreover, BAs are being considered as galenic agents to improve intestinal absorption of drugs compounds such as nucleotides, heparin or insulin [138][139][140] .…”

Section: Intestinal Applications Of Bamentioning

confidence: 99%

Intestinal bile acid physiology and pathophysiology

Martínez‐Augustin¹,

Medina²

2008

WJG

135

114

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Bile acids (BAs) have a long established role in fat digestion in the intestine by acting as tensioactives, due to their amphipathic characteristics. BAs are reabsorbed very efficiently by the intestinal epithelium and recycled back to the liver via transport mechanisms that have been largely elucidated. The transport and synthesis of BAs are tightly regulated in part by specific plasma membrane receptors and nuclear receptors. In addition to their primary effect, BAs have been claimed to play a role in gastrointestinal cancer, intestinal inflammation and intestinal ionic transport. BAs are not equivalent in any of these biological activities, and structural requirements have been generally identified. In particular, some BAs may be useful for cancer chemoprevention and perhaps in inflammatory bowel disease, although further research is necessary in this field. This review covers the most recent developments in these aspects of BA intestinal biology.

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“…delivery of oligonucleotides in both animals and man [11]. Permeation data from in vivo/in situ rodent studies of oligonucleotides calculate tight junction opening after C10 dosing to be consistent with the cross-sectional diameter of the singlestrand oligonucleotides [12]. It remains to be seen if double-stranded constructs will show the same degree of increased permeation when paracellular junctions are opened to the same degree.…”

Section: Oral Bioavailability Enhancement Of Nabtsmentioning

confidence: 90%

Oral Delivery of Nucleic acid-based Therapeutics

Hardee¹

2012

Therapeutic Delivery

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Systematic Studies on the Paracellular Permeation of Model Permeants and Oligonucleotides in the Rat Small Intestine with Chenodeoxycholate as Enhancer

Cited by 27 publications

References 36 publications

Bile acids in regulation of intestinal physiology

Bile acids in regulation of intestinal physiology

Intestinal bile acid physiology and pathophysiology

Oral Delivery of Nucleic acid-based Therapeutics

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