2003
DOI: 10.2337/diabetes.52.2.562
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Systematic Search for Single Nucleotide Polymorphisms in the FOXC2 Gene

Abstract: 1FOXC2, a forkhead/winged helix transcription factor, represents a promising candidate gene for type 2 diabetes since transgenic mice that specifically overexpress this gene in adipocytes are lean and insulin sensitive. To determine whether there are single nucleotide polymorphisms (SNPs) in this gene that are associated with type 2 diabetes, sequences of the coding and ϳ1 kb of 5 flanking regions in 24 Japanese type 2 diabetic subjects were initially analyzed using PCR direct sequencing, and the regions conta… Show more

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Cited by 19 publications
(18 citation statements)
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“…Our findings show that the FOXC2 -512C>T substitution is not a major cause of Type 2 diabetes in the Danish Caucasian population. This is consistent with previous reports in Japanese subjects [8] and Pima Indian subjects [9].…”
Section: Discussionsupporting
confidence: 94%
“…Our findings show that the FOXC2 -512C>T substitution is not a major cause of Type 2 diabetes in the Danish Caucasian population. This is consistent with previous reports in Japanese subjects [8] and Pima Indian subjects [9].…”
Section: Discussionsupporting
confidence: 94%
“…In agreement with our data, none of these studies performed in Japanese, 9 Pima Indians 8 and Danish Caucasians, 10 respectively, could show an association between FOXC2 and type 2 diabetes. However, also in agreement with our present data, a significant association between the À512C4T variant and BMI (P ¼ 0.03) and measures of body composition (percent body fat; P ¼ 0.02) was noted in Pima Indians.…”
Section: Discussionsupporting
confidence: 90%
“…7,8 Although these data identified FOXC2 as a candidate gene for insulin resistance and/or type 2 diabetes, three recent reports in Japanese, Pima Indians and Danish Caucasians have failed to identify an association between FOXC2 and type 2 diabetes. [8][9][10] In addition, contrasting with previous data, the Tallele was weakly associated with increased waist-to-hip ratio (WHR), plasma triglycerides and measures of insulin resistance in the Danish study. 10 Insulin resistance and additional features of the metabolic, or rather dysmetabolic, syndrome including abdominal obesity, hypertension and dyslipidemia are under strong genetic influence and cluster in families and they are the hallmark feature of type 2 diabetes.…”
Section: Introductioncontrasting
confidence: 91%
“…The genotype distributions for all SNPs were consistent with Hardy-Weinberg equilibrium (P Ͼ 0.13 vs. expected frequency, 2 test). There was no association of either the C-512T or the G-350T with type 2 diabetes in 937 full-blooded Pima Indians (611 diabetic and 326 nondiabetic subjects), which is consistent with a recent Japanese study (4). However, the C-512T SNP was associated with BMI in 644 Pimas with normal glucose tolerance who were at least 18 years of age.…”
supporting
confidence: 75%