Systematic Reviews and Meta-Analyses of Portal Vein Embolization, Associated Liver Partition and Portal Vein Ligation, and Radiation Lobectomy Outcomes in Hepatocellular Carcinoma Patients

Charalel, Resmi A.; Sung, Jeffrey C.; Askin, Gülce; Jo, Jonathan; Mitry, Maria; Chung, Caroline; Tmanova, Lyubov L.; Madoff, David C.

doi:10.1007/s11912-021-01075-1

Cited by 10 publications

(14 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hepatectomy is one of the best choice for curative treatment of patients with liver cancer [ 37 ]. Although the clinical outcome of hepatectomy has a marked improvement over the last few decades, numerous liver cancer patients are diagnosed at an unresectable stage (locally advanced or metastatic disease) and lost the opportunity to surgical treatment due to a small FLR and function [ 38 , 39 ]. To enhance FLR and resectability of large HCC, many techniques have been developed, such as PVE, ALPPS, and radiation lobectomy[ 39 ].…”

Section: Discussionmentioning

confidence: 99%

“…Although the clinical outcome of hepatectomy has a marked improvement over the last few decades, numerous liver cancer patients are diagnosed at an unresectable stage (locally advanced or metastatic disease) and lost the opportunity to surgical treatment due to a small FLR and function [ 38 , 39 ]. To enhance FLR and resectability of large HCC, many techniques have been developed, such as PVE, ALPPS, and radiation lobectomy[ 39 ]. All three treatments accelerate liver hypertrophy in liver cancer patients, but PVE is considered as the best choice based on the effective hypertrophy with a short time and low rate of complication [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

“…To enhance FLR and resectability of large HCC, many techniques have been developed, such as PVE, ALPPS, and radiation lobectomy[ 39 ]. All three treatments accelerate liver hypertrophy in liver cancer patients, but PVE is considered as the best choice based on the effective hypertrophy with a short time and low rate of complication [ 39 ]. In the study, our main aim was to uncover the crucial lncRNAs and mRNAs of PVL that promote liver regeneration similar to the mechanism of PVE.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Identification of crucial lncRNAs and mRNAs in liver regeneration after portal vein ligation through weighted gene correlation network analysis

Zhu

Zhang

et al. 2022

BMC Genomics

View full text Add to dashboard Cite

Background Portal vein ligation (PVL)-induced liver hypertrophy increases future liver remnant (FLR) volume and improves resectability of large hepatic carcinoma. However, the molecular mechanism by which PVL facilitates liver hypertrophy remains poorly understood. Methods To gain mechanistic insight, we established a rat PVL model and carried out a comprehensive transcriptome analyses of hepatic lobes preserving portal blood supply at 0, 1, 7, and 14-day after PVL. The differentially expressed (DE) long-non coding RNAs (lncRNAs) and mRNAs were applied to conduct weighted gene co-expression network analysis (WGCNA). LncRNA-mRNA co-expression network was constructed in the most significant module. The modules and genes associated with PVL-induced liver hypertrophy were assessed through quantitative real-time PCR. Results A total of 4213 DElncRNAs and 6809 DEmRNAs probesets, identified by transcriptome analyses, were used to carry out WGCNA, by which 10 modules were generated. The largest and most significant module (marked in black_M6) was selected for further analysis. Gene Ontology (GO) analysis of the module exhibited several key biological processes associated with liver regeneration such as complement activation, IL-6 production, Wnt signaling pathway, autophagy, etc. Sixteen mRNAs (Notch1, Grb2, IL-4, Cops4, Stxbp1, Khdrbs2, Hdac2, Gnb3, Gng10, Tlr2, Sod1, Gosr2, Rbbp5, Map3k3, Golga2, and Rev3l) and ten lncRNAs (BC092620, AB190508, EF076772, BC088302, BC158675, BC100646, BC089934, L20987, BC091187, and M23890) were identified as hub genes in accordance with gene significance value, module membership value, protein–protein interaction (PPI) and lncRNA-mRNA co-expression network. Furthermore, the overexpression of 3 mRNAs (Notch1, Grb2 and IL-4) and 4 lncRNAs (BC089934, EF076772, BC092620, and BC088302) was validated in hypertrophic liver lobe tissues from PVL rats and patients undergoing hepatectomy after portal vein embolization (PVE). Conclusions Microarray and WGCNA analysis revealed that the 3 mRNAs (Notch1, Grb2 and IL-4) and the 4 lncRNAs (BC089934, EF076772, BC092620 and BC088302) may be promising targets for accelerating liver regeneration before extensive hepatectomy.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Identification of crucial lncRNAs and mRNAs in liver regeneration after portal vein ligation through weighted gene correlation network analysis

Zhu

Zhang

et al. 2022

BMC Genomics

View full text Add to dashboard Cite

show abstract

“…are available for preoperative volumetric evaluation. In addition to providing volumetric data, newer software-based imaging devices can produce a three-dimensional reconstruction of the hepatic anatomy, tumour extent and its relation to vital structures [4 ▪▪ ,27,28 ▪▪ ]. It should nonetheless be highlighted that despite being a strong predictor of postoperative outcomes, liver volume is basically a surrogate marker for function.…”

Section: Quantitative Assessment Of the Livermentioning

confidence: 99%

“…Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is a relatively recent technique to aid hepatic resection in patients with small FLR and has the advantage of inducing much more rapid FLR hypertrophy as compared with PVE or PVL. ALPPS is completed in two-stages with the first stage involving in-situ portal vein ligation on the tumour side with parenchymal transection [6 ▪▪ ,11 ▪ ,28 ▪▪ ,31] (Fig. 2).…”

Section: Strategies For Functional Liver Remnant Volume Optimizationmentioning

confidence: 99%

Perioperative screening and management in elective complex hepatobiliary surgery

Rajakumar

Rammohan

Rela

2022

Current Opinion in Critical Care

View full text Add to dashboard Cite

Purpose of reviewPreoperative optimization and structured evidence-based perioperative care of a patient undergoing complex hepatobiliary (HPB) surgery are essential components in their management. Apart from advances in surgical technique, these perioperative measures have resulted in substantial reductions in morbidity and mortality. There hence, remains a continued need to have evidence-based updation in their management algorithm to ensure optimal outcomes. Recent findingsWe present an evidence-based overview of the preoperative screening, optimization and perioperative management of patients undergoing complex HPB surgery.

show abstract

Comparison of Complications in Patients with Ductal Cholangiocarcinoma (CCC) and Patients with Colorectal Liver Metastases (CRLMs) After Portal Vein Embolization (PVE): A Matched Cohort Study

De Beukelaer,

Van den Bosch,

Kuhl

et al. 2024

Cardiovasc Intervent Radiol

View full text Add to dashboard Cite

Systematic Reviews and Meta-Analyses of Portal Vein Embolization, Associated Liver Partition and Portal Vein Ligation, and Radiation Lobectomy Outcomes in Hepatocellular Carcinoma Patients

Cited by 10 publications

References 45 publications

Identification of crucial lncRNAs and mRNAs in liver regeneration after portal vein ligation through weighted gene correlation network analysis

Identification of crucial lncRNAs and mRNAs in liver regeneration after portal vein ligation through weighted gene correlation network analysis

Perioperative screening and management in elective complex hepatobiliary surgery

Comparison of Complications in Patients with Ductal Cholangiocarcinoma (CCC) and Patients with Colorectal Liver Metastases (CRLMs) After Portal Vein Embolization (PVE): A Matched Cohort Study

Contact Info

Product

Resources

About