Systematic review with meta‐analysis: the association between human papillomavirus infection and oesophageal cancer

Abstract

These two authors contributed to this work equally. SUMMARY BackgroundHuman papillomavirus (HPV) infection might be one of the potential risk factors for oesophageal cancer. However, the previous epidemiological findings were heterogeneous.

Molecular Detection of High Risk Human Papilloma Viruses (HR-HPV 16 and 18) among Patients with Esophageal Cancer

“…Significant association was observed between HR-HPV infection and esophageal squamous cell carcinoma with a summarized odds ratio of 3.32 (95% CI, 2.26-4.87). According to HR-HPV16, the strength of the association was found to be 3.52 (95% CI, 2.04-6.07) [18]. Though HR-HPV18 was not detected in the present study but studies have reported low prevalence rates in the highly infected regions [19].…”

Prevalence of high Risk Human Papilloma Viruses 16 and 18 (HR-HPV16&18) Among Sudanese Patients with Esophageal Cancer

“…Significant association was observed between HPV infection and esophageal SCC with a summarized odds ratio of 3.32 (95% CI, 2.26-4.87). According to HPV16, the strength of the association was found to be 3.52 (95% CI, 2.04-6.07) [16]. Though HPV18 was not detected in the present study but studies have reported low prevalence rates in the highly infected regions [17].…”

Prevalence of Human Papillomavirus 16 in Esophageal Cancer Among the Chinese Population: a Systematic Review and Meta-analysis

“…Results in this study were consistent with these recent meta-analysis and even with a higher prevalence level in our study because the included cases were testing by PCR method which can improve the HPV 16 positive rate in the case tissues. Furthermore, as Li reported (Li et al, 2014), HPV infection might be disappeared during the development of cancer and this clearance of HPV infection may lead to underestimation of the HPV 16 infection. In other words, the high prevalence of HPV 16 may suggested a relative high overall HPV prevalence in esophageal cancer cases.…”

“…With respect to esophageal cancer, studies also reported that HPV 16 was the main HPV type (Yong et al, 2013;Li et al, 2014;Petrick et al, 2014), although there is a controversy on this issue. Meta-analysis conducted by Petrick et al showed that HPV 16 prevalence ranged from 17.3% to 35.9% in esophageal cancer using different detecting method (Petrick et al, 2014).…”