2022
DOI: 10.1111/apt.16924
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Systematic review with meta‐analysis: outcomes of pregnancy in patients with autoimmune hepatitis

Abstract: Background: Autoimmune hepatitis (AIH) is common in females of childbearing age.Although some studies have provided information about the outcomes of pregnancy, there remains uncertainty regarding conclusions.

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Cited by 10 publications
(11 citation statements)
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References 65 publications
(110 reference statements)
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“…LBW and very low birth weight (VLBW) were noted in 14.1% and 4.2% in this study versus 4.8% and 0.9% in the general population 28 . The incidence of preterm birth was similar compared to 12%–22% reported in AIH, 14–17,24 with exception of 7% in a small study 29 . No risk factors were found for preterm birth and no association was found between the use of azathioprine and preterm birth.…”
Section: Discussionsupporting
confidence: 71%
See 1 more Smart Citation
“…LBW and very low birth weight (VLBW) were noted in 14.1% and 4.2% in this study versus 4.8% and 0.9% in the general population 28 . The incidence of preterm birth was similar compared to 12%–22% reported in AIH, 14–17,24 with exception of 7% in a small study 29 . No risk factors were found for preterm birth and no association was found between the use of azathioprine and preterm birth.…”
Section: Discussionsupporting
confidence: 71%
“…10 The available evidence shows that overall the outcome of pregnancy in AIH is good, but it has been associated with an increased incidence of complications. [11][12][13][14][15][16][17] There are less data evaluating the influence of AIH control on maternal and perinatal outcomes.…”
Section: Introductionmentioning
confidence: 99%
“…In general, pregnancy and childbirth seem to be safe for both mother and child. [64][65][66][67][68][69] If not properly controlled, however, autoimmune hepatitis can flare up during pregnancy, and this is associated with a high rate of fetal and maternal complications within the range of 10-20%. Pregnancy should be initiated when the disease is in stable and persistent remission, 4 and immunosuppression with azathioprine should be neither reduced nor suspended, as its teratogenic potential in animals is not observed in humans.…”
Section: Older and Pediatric Patientsmentioning
confidence: 99%
“…Many female patients with autoimmune hepatitis at childbearing age request information on pregnancy in relation to their hepatic condition. In general, pregnancy and childbirth seem to be safe for both mother and child 646566676869. If not properly controlled, however, autoimmune hepatitis can flare up during pregnancy, and this is associated with a high rate of fetal and maternal complications within the range of 10-20%.…”
Section: Special Patient Populations With Autoimmune Hepatitismentioning
confidence: 99%
“…The same meta-analysis demonstrated lower DA and risk of biochemical flare intrapartum compared to postpartum (relative risk, 0.31; p < 0.00001) except in those with portal hypertension who had increased risk of intrapartum loss of biochemical remission (LOBR). [5] Interestingly, stable disease at conception was associated with fewer postpartum LOBR and PTB. Preconception counseling would be the ideal opportunity to optimize DA before conception and manage patients with high risk with significant portal hypertension.…”
mentioning
confidence: 99%