Systematic review with meta‐analysis: dietary intake in adults with inflammatory bowel disease

Abstract

Summary Background Poor dietary intake is associated with the development of malnutrition, micronutrient deficiencies, anaemia and osteoporosis in individuals with inflammatory bowel disease. While trials are underway to manipulate the diet of people with IBD, there has been no comprehensive systematic review of the dietary intake of adults with IBD. Aims To conduct a systematic evaluation and meta‐analysis of the dietary intake of adults with IBD, including macronutrients, micronutrients and food group data. Methods CINAHL, Embase, Medline and Scopus were searched from 1 January 2000 to 25 September 2020 for cohort, case–control or cross‐sectional studies that reported usual dietary intake in adults. Data were pooled and reported as weighted mean intake for: all adults with IBD; Crohn's disease; ulcerative colitis; active disease; remission; males; females. A random‐effects meta‐analysis model compared intake with healthy individuals. Results Forty studies were identified and 19 were included in the meta‐analysis. All subgroups of adults with IBD consumed inadequate energy (mean intake in adults with IBD 1980 ± 130 kcal), fibre (14 ± 4 g), folate (246 ± 33 mg) and calcium (529 ± 114 mg) per day. Intake of breads and cereals, legumes, fruit, vegetables and dairy were inadequate. Compared to healthy individuals, adults with IBD consume significantly less dietary fibre (SMD −0.59; 95% CI: −0.73, −0.46). Conclusions This review provides improved clarity about the dietary intake of adults with IBD. Future attention is required to improve diet quality and increase understanding of factors influencing dietary intake in IBD.

Mucolytic bacteria license pathobionts to acquire host-derived nutrients during dietary nutrient restriction

“…Generally, L-serine is contained in proteinrich foods, such as meat, fish, eggs, and soybeans. A recent systematic review has shown that fiber and calcium intakes are insufficient in IBD, whereas protein intake meets or exceeds the recommended amount (Lambert et al, 2021). Therefore, the reduced concentration of L-serine in the gut lumen of individuals with IBD may be caused by the excessive consumption of L-serine by the gut microbiota or the host cells rather than by the insufficient intake of protein.…”

Mucolytic bacteria license pathobionts to acquire host-derived nutrients during dietary nutrient restriction

“…Generally, L-serine is contained in protein-rich foods, such as meat, fish, eggs, and soybeans. A recent systematic review has shown that fiber and calcium intakes are insufficient in IBD, whereas protein intake meets or exceeds the recommended amount (Lambert et al, 2021). Therefore, the reduced concentration of L-serine in the gut lumen of individuals with IBD may be caused by the excessive consumption of L-serine by the gut microbiota or the host cells rather than by the insufficient intake of protein.…”

New Diagnostic Possibilities for Determining the Activity of Ulcerative Colitis: The Role of Neutrophils

“…Недавно проведенный метаанализ 19-ти исследований продемонстрировал важную роль питания в развитии ВЗК [8]. Целью этого исследования стало обобщение данных о повседневном рационе питания взрослых с ВЗК по сравнению со здоровыми людьми, сопоставимыми по возрасту и полу.…”