Systematic review: the effects of conservative and surgical treatment for obesity on gastro‐oesophageal reflux disease

“…These varied results of weight loss on GERD symptoms could be because of small sample size, gender differences, wide variation in BMI of subjects (23 vs. 43), and use of different weight loss methods (various lifestyle changes vs. surgical approaches) (21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35). Furthermore, a number of lifestyle intervention treatments have been attempted for GERD-low calorie diet, use of fruits/ vegetables, and physical activity; individually each intervention has no direct correlation with GERD improvement as shown in previous population-based studies (13,22,23) and a recent meta-analysis (32).…”

Section: Discussionmentioning

confidence: 99%

“…Previous data on the impact of weight loss achieved through various lifestyle (dietary changes and physical activity) (21)(22)(23)(24)(25) or surgical methods (Roux-en-Y gastric bypass or vertical band gastroplasty) (26)(27)(28)(29)(30) on GERD symptoms are scarce and with conflicting results (31). A systematic review evaluating the effects of various life style changes on GERD symptoms suggested that weight loss and head of bed elevation could improve symptoms of GERD (32).…”

Section: Introductionmentioning

confidence: 99%

Weight Loss Can Lead to Resolution of Gastroesophageal Reflux Disease Symptoms: A Prospective Intervention Trial

Singh¹,

Lee²,

Gupta³

et al. 2012

Obesity

View full text Add to dashboard Cite

Objective-Weight gain is an important risk factor for gastroesophageal reflux disease (GERD); however, whether weight loss can lead to resolution of GERD symptoms is not clear. Our aim was to measure the impact of weight loss on GERD symptoms.Design and Methods-In a prospective cohort study at a tertiary referral center, overweight/ obese subjects (BMI 25-39.9 kg/m2) were enrolled in a structured weight loss program. Weight loss strategies included dietary modifications, increased physical activity and behavioral changes. At baseline and at 6 months, BMI and waist circumference were measured and all participants completed a validated reflux disease questionnaire.Results-A total of 332 adult subjects, mean age 46 years and 66% women were prospectively enrolled. At baseline, the mean body weight, BMI, and waist circumference were 101 (±18) kg, 35 (±5) kg/m2 and 103 (±13) cm. At 6 months, majority of the subjects (97%) lost weight (average weight loss: 13 ± 7.7 kg) and as compared with baseline, there was a significant decrease in the overall prevalence of GERD (15 vs. 37%; P < 0.01) and the mean GERD symptom score (1.8 vs. 5.5; P < 0.01). Overall, 81% of the subjects had reduction in GERD symptom scores; 65% had complete resolution and 15% had partial resolution of reflux symptoms. There was a significant correlation between % body weight loss and reduction in GERD symptom scores (r = 0.17, P < 0.05).Conclusions-In conclusion, the overall prevalence of GERD symptoms is high (37%) in overweight and obese subjects. A structured weight loss program can lead to complete resolution of GERD symptoms in the majority of these subjects.

show abstract

“…Although weight loss and lifestyle modifications are important in reducing the symptoms of GERD, different bariatric surgeries have provided varying degrees of symptom alleviation. 17 De Groote and colleagues 17 performed a systematic review of bariatric surgery and GERD and compared the data with lifestyle modification. They found that lifestyle modification led to a decrease in GERD symptoms in 4 of 7 studies.…”

Section: Reviewmentioning

confidence: 99%