Systematic review: patient-reported outcome measures of fatigue in inflammatory bowel disease

Fan, Vanessa S. K.; Mehdipour, Ava; O’Grady, Heather K.; Richardson, Julie; Griffith, Lauren; Campbell, Kristin L.; Bosch, Jackie

doi:10.1080/21641846.2022.2073157

Cited by 3 publications

(3 citation statements)

References 41 publications

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“…Over 250 different scales have been reported, of which at least nine have been used for research on IBD-related fatigue and five have been validated for this purpose. These include the functional assessment of chronic illness therapy fatigue (FACIT-F), the fatigue questionnaire (FQ), multidimensional assessment fatigue (MAF), the multidimensional fatigue inventory (MFI), and the inflammatory bowel disease fatigue (IBD-F); of which the latter is recommended for research and clinical use ( 22 , 23 ).…”

Section: Definition Of Ibd-related Fatigue and Its Assessmentmentioning

confidence: 99%

Unraveling the fatigue puzzle: insights into the pathogenesis and management of IBD-related fatigue including the role of the gut-brain axis

Truyens,

Lernout,

De Vos

et al. 2024

Front. Med.

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A significant percentage of patients with an inflammatory bowel disease (IBD) encounter fatigue which can profoundly diminish patients’ quality of life, particularly during periods of disease remission when gastrointestinal symptoms have receded. Various contributing risk factors have been identified including active inflammation, anemia, psychological, lifestyle and drug-related factors. While addressing these risk factors has been suggested as the initial approach to managing fatigue, a considerable number of patients still experience persisting symptoms, the primary causes of which remain incompletely understood. Recent insights suggest that dysfunction of the gut-brain axis may play a pathogenic role. This review provides an overview of established risk factors for fatigue, alongside emerging perspectives on the role of the gut-brain axis, and potential treatment strategies.

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Section: Definition Of Ibd-related Fatigue and Its Assessmentmentioning

confidence: 99%

Unraveling the fatigue puzzle: insights into the pathogenesis and management of IBD-related fatigue including the role of the gut-brain axis

Truyens,

Lernout,

De Vos

et al. 2024

Front. Med.

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“…Despite its high prevalence and substantial impact, several knowledge gaps remain including the best way to measure fatigue (17), how fatigue evolves over time at the level of the individual (9,(18)(19)(20), the etiology of fatigue (21), and optimal management approaches (22). The few longitudinal studies that have examined predictors of fatigue have focused on average effects in the IBD population (9,(18)(19)(20), rather than changes in fatigue over time in individuals with IBD, and predictors of those changes.…”

Section: Introductionmentioning

confidence: 99%

Understanding Predictors of Fatigue Over Time in Persons With Inflammatory Bowel Disease: The Importance of Depressive and Anxiety Symptoms

Bernstein,

Fisk,

Dolovich

et al. 2023

Am J Gastroenterol

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Background Fatigue is a complex and frequent symptom in persons with IBD, with detrimental impact. We aimed to determine predictors of fatigue over time. Methods: 247 adults with IBD participated in a prospective study conducted in Manitoba, Canada, providing data at baseline and annually for 3 years. Participants reported fatigue impact (Daily Fatigue Impact Scale [DFIS]), depression and anxiety symptoms (Hospital Anxiety and Depression Scale [HADS]) and pain (Pain Effects Scale [PES]). Physician-diagnosed comorbidities, IBD characteristics, physical and cognitive functioning were also assessed. We tested factors associated with fatigue using multivariable generalized linear models that estimated within-person and between-person effects. Results: Most participants were women (63.2%), White (85.4%) and had Crohn’s disease (62%). At baseline, 27.9% reported moderate-severe fatigue impact,16.7% had clinically elevated anxiety (HADS-A ≥11) and 6.5% had clinically elevated depression (HADS-D ≥11). Overall fatigue burden was stable over time though approximately half the participants showed improved or worsening fatigue impact between annual visits during the study. On multivariable analysis, participants with a one-point higher HADS-D score had, on average, a 0.63-point higher DFIS score, while participants with a one-point higher PES score had a 0.78-point higher DFIS score. Within-individuals, a one-point increases in HADS-D score was associated with a 0.61-point higher DFIS scores, in HADS-A scores with a 0.23-point higher DFIS scores, and in PES scores with 0.38-point higher DFIS scores. No other variables predicted fatigue. Conclusions: Anxiety, depression and pain predicted fatigue impact over time in IBD, suggesting that targeting psychological factors and pain for intervention may lessen fatigue burden.

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“…These patients with IBD preferred the IBD-F since it best reflects their experience of fatigue [ 5 ]. Furthermore, a recent systematic review on PROMs concerning fatigue in patients with IBD, recommended the use of the IBD-F to evaluate fatigue in this population [ 18 ]. This self-assessment scale was developed in the United Kingdom and was translated into different languages and validated in multiple countries [ 19 – 23 ].…”

Section: Introductionmentioning

confidence: 99%

Translation, validation and psychometric properties of the Dutch version of the Inflammatory Bowel Disease-Fatigue (IBD-F) self-assessment scale

Stoker,

Gruters,

Loon

et al. 2023

J Patient Rep Outcomes

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Background In patients with inflammatory bowel disease (IBD), a symptom with major impact on health-related quality of life is fatigue. To assess fatigue and conduct research regarding fatigue in IBD patients, a validated disease specific assessment tool is required. The aim of this study was to translate the Inflammatory Bowel Disease Fatigue patient self-assessment scale (IBD-F) into Dutch and to validate this translated scale in a Dutch IBD population. Methods The study comprised three phases. In phase 1, the original IBD-F was translated into Dutch. Phase 2 comprised a pilot-test of the pre-final Dutch IBD-F to assess content validity by applying a semi-structured interview design. In phase 3, construct validity, internal consistency and test-retest reliability were assessed using a cross-sectional design. Results Phase 1 resulted in the pre-final version of the Dutch IBD-F. After five semi-structured interviews with IBD patients in phase 2, minor adjustments were made which resulted in the final version of the Dutch IBD-F. Evaluation of this final version in 133 IBD patients showed adequate psychometric properties: good convergent validity with the Multidimensional Fatigue Inventory subscales (Spearman’s r 0.57–0.86) and excellent internal consistency (Cronbach’s alpha 0.94 for Section I and 0.97 for Section II). Test-retest reliability in 102 patients was shown to be good (Section I ICC 0.85 (95% CI 0.79–0.90) and Section II ICC 0.88 (95% CI 0.83–0.92)). Conclusions The thorough translation process resulted in a comprehensible, valid and reliable version of the Dutch IBD-F. Convergent validity with the MFI-20 appeared to be good. This study found excellent internal consistency and good test-retest reliability.

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Systematic review: patient-reported outcome measures of fatigue in inflammatory bowel disease

Cited by 3 publications

References 41 publications

Unraveling the fatigue puzzle: insights into the pathogenesis and management of IBD-related fatigue including the role of the gut-brain axis

Unraveling the fatigue puzzle: insights into the pathogenesis and management of IBD-related fatigue including the role of the gut-brain axis

Understanding Predictors of Fatigue Over Time in Persons With Inflammatory Bowel Disease: The Importance of Depressive and Anxiety Symptoms

Translation, validation and psychometric properties of the Dutch version of the Inflammatory Bowel Disease-Fatigue (IBD-F) self-assessment scale

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