Systematic review of the use of cyanoacrylate glue in addition to standard wound closure in the prevention of surgical site infection

Abstract

Surgical site infection (SSI) is associated with increased morbidity, length of stay, and cost. Cyanoacrylate glue is a low‐cost, fluid‐proof, antimicrobial barrier. The aim of this systematic review is to assess the use of cyanoacrylate glue after standard wound closure versus dressings in the reduction of SSI. Medline, Embase, Cochrane Library, and clinical trial registries were searched with no restrictions in accordance with PRISMA guidelines. Eligibility criteria were prospective studies comparing glue versus dressings after standardised wound closure. Two reviewers independently screened articles and utilised GRADE for quality assessment. Meta‐analysis was not performed because of the heterogeneity of the data. Three articles were included in the review. Study quality was uniformly low. Incidence of SSI was low, between 0% and 4%. No significant differences were reported in the single randomised controlled trial. A single non‐randomised parallel group trial reported a significant reduction in the incidence of SSI in the cyanoacrylate group. There was no consistent evidence demonstrating reduction in SSI as a result of the use of cyanoacrylate glue. Future studies should assess the use of cyanoacrylate in procedures with a higher rate of SSI, for example, lower limb bypass.

Comparative analysis of the hemostatic, analgesic and healing effects of cyanoacrylate on free gingival graft surgical wounds in donor and recipient areas: a systematic review

“…Cyanoacrylate stands out among the materials on the market for the closure of surgical wounds which has been pointed out by different authors [ 1 , 3 , 4 , 6 ] as being an alternative to conventional suture materials due to their hemostatic [ 18 , 19 ], analgesic [ 9 , 18 , 19 ], and healing properties [ 6 , 9 , 19 ]. Moreover, studies [ 1 , 14 ] demonstrate that the application of cyanoacrylate records a shorter surgery time than the suturing groups ( p < 0.05).…”

“…The main advantages of bioadhesive materials are generally attributed to the following factors: high tissue compatibility and long half-life; presence of hemostatic, analgesic and antibacterial properties; high potential for adhesiveness and biodegradation; the ability to maintain the position/stabilization of injured tissues; and to trigger a mild inflammatory response [ 3 , 4 , 6 , 9 ].…”

“…Cyanoacrylate adhesives have been extensively used for closing skin wounds and in several surgical procedures involving skin, mucous membranes and different tissues, including oral tissues [3][4][5]. These adhesives have been applied in the oral cavity for flap closure, gingival graft fixation, and pulp capping [1,[6][7][8].…”

Redirecting drug repositioning to discover innovative cosmeceuticals

“…The ability of cyanoacrylates to act as adhesives in wound healing was recognized, subsequently. Nevertheless, polymerization of methyl and ethyl cyanoacrylates is an exothermic reaction, but cyanoacrylate esters with higher alcohols, n‐butyl cyanoacrylate (Histoacryl) and the 2‐octyl cyanoacrylate (Dermabond) polymerize in significant less exothermic manner and are used for medical purposes 143 . Cyanoacrylates could also prevent wound contamination via their antimicrobial effects against Gram(+) bacteria 143 .…”

“…Nevertheless, polymerization of methyl and ethyl cyanoacrylates is an exothermic reaction, but cyanoacrylate esters with higher alcohols, n‐butyl cyanoacrylate (Histoacryl) and the 2‐octyl cyanoacrylate (Dermabond) polymerize in significant less exothermic manner and are used for medical purposes 143 . Cyanoacrylates could also prevent wound contamination via their antimicrobial effects against Gram(+) bacteria 143 . Cyanoacrylates are also used in cosmetics as glues in artificial eyelash extensions 144 and as nail glues 145 …”