Systematic review of the use of fibrin sealant in abdominal-wall repair surgery

Abstract

Compared with mechanical methods, fibrin sealant is an efficacious alternative for mesh fixation postsurgery of the abdominal wall.

The effect of TISSEEL fibrin sealant on seroma formation following complex abdominal wall hernia repair: a single institutional review and derived cost analysis

“…Additionally, the same holds true for our secondary measures as hernia recurrence rate, as longer follow-up of the patients may reveal additional surgical site occurrences. Also, the amount of fibrin sealant used in our study (2 ml per 10 cm 2 defect size), although within the maximum range suggested by the manufacturer, is a greater amount than previous studies (1-2 ml per 16-40 cm 2 ) that have demonstrated successes with its use [17,18]. A lesser amount of fibrin sealant may prove advantageous and further studies are ongoing to explore this topic.…”

“…Tissucol Ò was used in the space between the prosthesis and the hernia sac, at an average of 1 ml per 16 cm 2 of defect size [18]. A significant reduction in the incidence and volume of the seromas in the sealant group was noted at 7 days and 1 month after surgery [18]. Similarly, Férnandez et al noted significantly less local morbidity and a shorter hospital stay in patients who had Tissucol applied following incisional hernia repair with dermolipectomy [19].…”

“…However, data are limited to small case series with fewer than 50 patients in the treatment and control groups [9,16,17]. Morales-Conde et al performed a prospective non-randomized single-center study on 50 patients undergoing laparoscopic ventral hernia repair divided into two groups with and without sealant (Tissucol Ò Duo: Baxter, Vienna, Austria) [18]. Tissucol Ò was used in the space between the prosthesis and the hernia sac, at an average of 1 ml per 16 cm 2 of defect size [18].…”

“…Morales-Conde et al performed a prospective non-randomized single-center study on 50 patients undergoing laparoscopic ventral hernia repair divided into two groups with and without sealant (Tissucol Ò Duo: Baxter, Vienna, Austria) [18]. Tissucol Ò was used in the space between the prosthesis and the hernia sac, at an average of 1 ml per 16 cm 2 of defect size [18]. A significant reduction in the incidence and volume of the seromas in the sealant group was noted at 7 days and 1 month after surgery [18].…”

A Meta-Analysis Examining the Use of Fibrin Glue Mesh Fixation versus Suture Mesh Fixation in Open Inguinal Hernia Repair

“…Generally, sutures are generally used to secure the prosthetic mesh; however, that may lead to chronic pain and other problems such as numbness or groin discomfort, presumably through tension or nerve compression [5]. Some studies showed that chronic pain was influenced by the type of the mesh implanted and its fixation [22,23]. For these reasons, some surgeons searched for a new type of atraumatic methods of fixation.…”