Systematic Review of the Risk of Parkinson's Disease After Mild Traumatic Brain Injury: Results of the International Collaboration on Mild Traumatic Brain Injury Prognosis

Marras, Connie; Hincapié, Cesar A.; Kristman, Vicki L.; Cancelliere, Carol; Soklaridis, Sophie; Li, Alvin; Borg, Jörgen; Geijerstam, Jean-Luc af; Cassidy, J. David

doi:10.1016/j.apmr.2013.08.298

Cited by 80 publications

(55 citation statements)

References 22 publications

(39 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A systematic review of the literature from 1990-2012 identified just five high-quality studies assessing risk of PD after MTBI. 5 Of the two studies that reported an elevated risk of PD after MTBI, the study authors themselves were not convinced, attributing their positive results to reverse-causation in one study 29 and sub-optimal matching of controls in the other. 42 The other three studies in the meta-analysis, however, did not find an association between MTBI and PD.…”

Section: Does Mtbi Increase Risk For Neurodegeneration?mentioning

confidence: 99%

“…3 Relatively fewer studies have assessed the association specifically between mild TBI (MTBI) and neurodegenerative diseases, and thus this association is not as well established. 4, 5 Since the highly publicized report of a series of autopsy cases of professional American football players with chronic traumatic encephalopathy (CTE), 6, 7 however, there has been a resurgence of interest in unraveling the potential link between MTBI and neurodegenerative disease including CTE. This resurgence of interest has led to a number of recent studies that have investigated the risk of neurodegenerative diseases following MTBI or prevalence of neurodegenerative diagnoses or suggestive symptoms among individuals with high levels of exposure to repetitive MTBI.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Epidemiology of mild traumatic brain injury and neurodegenerative disease

Gardner

Yaffe

2015

Molecular and Cellular Neuroscience

527

341

View full text Add to dashboard Cite

Every year an estimated 42 million people worldwide suffer a mild traumatic brain injury (MTBI) or concussion. More severe traumatic brain injury (TBI) is a well-established risk factor for a variety of neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). Recently, large epidemiological studies have additionally identified MTBI as a risk factor for dementia. The role of MTBI in risk of PD or ALS is less well established. Repetitive MTBI and repetitive sub-concussive head trauma has been linked to increased risk for a variety of neurodegenerative diseases including chronic traumatic encephalopathy (CTE). CTE is a unique neurodegenerative tauopathy first described in boxers but more recently described in a variety of contact sport athletes, military veterans, and civilians exposed to repetitive MTBI. Studies of repetitive MTBI and CTE have been limited by referral bias, lack of consensus clinical criteria for CTE, challenges of quantifying MTBI exposure, and potential for confounding. The prevalence of CTE is unknown and the amount of MTBI or sub-concussive trauma exposure necessary to produce CTE is unclear. This review will summarize the current literature regarding the epidemiology of MTBI, post-TBI dementia and Parkinson's disease, and CTE while highlighting methodological challenges and critical future directions of research in this field.

show abstract

Section: Does Mtbi Increase Risk For Neurodegeneration?mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Epidemiology of mild traumatic brain injury and neurodegenerative disease

Gardner

Yaffe

2015

Molecular and Cellular Neuroscience

527

341

View full text Add to dashboard Cite

show abstract

“…24 No evidence is currently available to show a causal link between repetitive subconcussive 67 although the relationship between mTBI and PD risk remains uncertain. 68 In paediatric populations, particularly young athletes, the effects of single or repetitive concussions on the risk of later-life neurodegeneration and dementia are unknown. CTE was first described symptomatically in the late 1920s as 'punch-drunk' dementia in boxers, 69 was later described as 'dementia pugilistica' , 70 and was first described pathologically in 1973.…”

Section: Subconcussive Blowsmentioning

confidence: 99%

Mind the gaps—advancing research into short-term and long-term neuropsychological outcomes of youth sports-related concussions

et al. 2015

View full text Add to dashboard Cite

“…ICoMP accepted five studies examining the risk of developing Parkinson’s disease (PD) following MTBI [34]. One Phase III study found an association between MTBI and PD, but only if the first PD diagnosis occurred within nine or less years of the initial injury.…”

Section: Reviewmentioning

confidence: 99%

“…Reverse causality however, likely explains the shorter time interval associated with injury and disease onset; that is to say that early stages of PD when it is not yet diagnosed may cause a fall resulting in MTBI. Collectively, the ICoMP evidence does not suggest an association between PD and MTBI [34]. …”

Section: Reviewmentioning

confidence: 99%

Summary of the findings of the International Collaboration on Mild Traumatic Brain Injury Prognosis

2014

Self Cite

View full text Add to dashboard Cite

In 2004, the WHO Collaborating Centre for Neurotrauma, Prevention, Management and Rehabilitation Task Force published the first large systematic review and best evidence synthesis on the clinical course and prognosis for recovery after MTBI. Ten years later, the International Collaboration on Mild Traumatic Brain Injury Prognosis (ICoMP) formed to update the original WHO Task Force results. This summary review highlights important clinical findings from the full ICoMP results including the current evidence on the course and prognosis of recovery after MTBI in diverse patient populations (e.g., adults, athletes and children) and injury environments (e.g., motor vehicle collisions) as well as on the risk of long-term outcomes after MTBI, such as Parkinson’s disease and dementia. Additional clinical areas of interest in MTBI are also discussed including the similarities between MTBI and other traumatic injuries and the risk of Second Impact Syndrome after sport concussion. Clinicians can use this information to help inform patients on the likely course of recovery after MTBI/concussion and guide better decision-making in the care of these patients.

show abstract

Systematic Review of the Risk of Parkinson's Disease After Mild Traumatic Brain Injury: Results of the International Collaboration on Mild Traumatic Brain Injury Prognosis

Cited by 80 publications

References 22 publications

Epidemiology of mild traumatic brain injury and neurodegenerative disease

Epidemiology of mild traumatic brain injury and neurodegenerative disease

Mind the gaps—advancing research into short-term and long-term neuropsychological outcomes of youth sports-related concussions

Summary of the findings of the International Collaboration on Mild Traumatic Brain Injury Prognosis

Contact Info

Product

Resources

About