Systematic Review of the Risk of Dementia and Chronic Cognitive Impairment After Mild Traumatic Brain Injury: Results of the International Collaboration on Mild Traumatic Brain Injury Prognosis

Godbolt, Alison K.; Cancelliere, Carol; Hincapié, Cesar A.; Marras, Connie; Boyle, Eleanor; Kristman, Vicki L.; Coronado, Victor G.; Cassidy, J. David

doi:10.1016/j.apmr.2013.06.036

Cited by 103 publications

(70 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several studies and meta-analyses have not found an association between TBI and risk of dementia. 1–5 Many prior studies have had notable limitations including recall bias due to self-reported diagnoses, 6–10 possible reverse causality 11 if patients with dementia have increased risk of TBI, possible confusion with post-concussive syndrome due to transient post-TBI cognitive symptoms, 12,13 or possible confounding if TBI patients are compared to healthy controls who may differ in many ways from patients prone to TBI. 13 Even among studies reporting a positive association between TBI and dementia, there is dramatic variability in the magnitude of reported risk, which may be due to differences in TBI severity, age of subjects, and follow-up period (with some being as short as two years) between studies.…”

Section: Introductionmentioning

confidence: 99%

Dementia Risk After Traumatic Brain Injury vs Nonbrain Trauma

et al. 2014

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Dementia Risk After Traumatic Brain Injury vs Nonbrain Trauma

et al. 2014

View full text Add to dashboard Cite

“…Other authors question whether a direct link exists between TBI and dementia, and instead suggest that a history of TBI in late life, combined with the brain changes associated with normal aging, might lead to more rapid cognitive decline in older adults [57]. The final review paper, the met inclusion criteria, was a systematic review which found insufficient evidence to draw any conclusion about a potential risk for dementia after mTBI [58].…”

Section: • Studies Reporting a Conditional Relationship Between Tbi Andmentioning

confidence: 99%

Traumatic Brain Injury As a Risk Factor for Alzheimer’s Disease: Current Knowledge and Future Directions

Dams-O’Connor

Guetta

Hahn-Ketter

et al. 2016

Neurodegener. Dis. Manag.

View full text Add to dashboard Cite

There is growing concern about the late effects of traumatic brain injury (TBI). This scoping review summarizes clinical research from the past 10 years that evaluates the relationship between TBI and Alzheimer's disease. This review identified five studies that found increased risk for dementia after TBI, two studies that found no increased risk and four studies that found a relationship only under certain conditions or in specified subsamples. Methodological differences across studies preclude direct comparison of results, and discrepant findings elucidate the complex course of post-TBI neurodegeneration. We discuss the factors that influence the strength and direction of the relationship between TBI and Alzheimer's disease, and the implications of this body of research for patient care and future research.

show abstract

“…Previous reports were conflicting, which created controversy over whether a preceding traumatic head injury predisposed an individual to an increased incidence of PD (Bower et al, 2003;Fang et al, 2012;Rugbjerg et al, 2008;Spangenberg et al, 2009). A systemic review article concluded that there was no significant relationship between mild traumatic brain injury and PD (Godbolt et al, 2014). However, there is no literature on the relationship of BPPV, head injury, and PD.…”

Section: Discussionmentioning

confidence: 96%