Systematic review of the efficacy of topical haemoglobin therapy for wound healing

Abstract

Hypoxia is a common cause of poor wound healing, for which a variety of oxygen therapies have been developed. In order to overcome the limitations of traditional methods of treatment, namely the type of equipment, its setting, safety and cost, local haemoglobin therapy has been developed, although no reviews have so far been published. Here, we systematically review the current evidence to establish the efficacy, scope, adverse reactions, and required precautions of this new form of therapy. A search of the literature was conducted in the PubMed, Embase, Scopus, CENTRAL, CINAHL, and Web of science databases, with 17 studies meeting the eligibility criteria, comprising one animal model study and 16 clinical studies. Local haemoglobin therapy is able to safely and effectively promote the healing of a variety of wounds, especially those that are chronic and non‐healing. However, premature discontinuation of this treatment can result in impediment to wound healing and even deterioration of the wound. The distinct benefit of the elimination of slough and relief of pain suggests that this technique may represent a new generation of debridement technology. Furthermore, its ease of use and convenience enables patient self‐management, thereby greatly reducing health care costs.

Topical oxygen therapy for treating diabetic foot ulcers: a WHAM evidence summary

“…1.a Systematic review of randomised controlled trials (RCTs) [1][2][3]5 1.b Systematic review of RCTs and studies of other designs 4,[6][7][8][9]…”

“…34 This intervention is designed to increase oxygen supply to the wound bed through the application of a topical, aqueous, haemoglobin-containing spray. 8,9 Because haemoglobin is capable of transporting oxygen within the body, the spray is designed to promote oxygen-binding in the wound bed from the surrounding air for transport deeper into the wound bed and diffusion into cells to promote healing. 9 In the laboratory, the spray has been demonstrated to increase angiogenesis, cell proliferation and collagen deposition.…”

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Level 1 evidenceStudies reported in included 1.a and 1.b systematic reviews

Experimental designs1.a Systematic review of randomised controlled trials (RCTs) [1][2][3]5 1.b Systematic review of RCTs and studies of other designs 4,[6][7][8][9]

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Effectiveness of the healing rate of sickle wounds with musa acuminata colla genome AA extract gel on rattus novergicus

“…The wound healing occurs gradually, starting with inflammation, polypheration, and regeneration (Hu, Guo, Hu, & Sun, 2020;Majewski, 2006;Primadina, Basori, & Perdanakusuma, 2019). In general, wound healing occurs through four stages: hemostatic, inflammatory, proliferation, and remodelling.…”

Contribuições Do Enfermeiro Na Pesquisa Básica: Modelo De Fixação De Curativo Em Feridas Cutâneas Excisionais De Camundongos

“…Na enfermagem ainda se mantém o debate sobre a relevância do uso de animais na pesquisa sobre temáticas dessa área de conhecimento 3 . Contudo alguns estudos começaram a ser produzidos na área, especialmente aqueles visando a integração da ciência básica a conteúdos do reparo tecidual das feridas 6,7 . Acredita-se que o uso das tecnologias disponíveis para o tratamento das feridas cutâneas pode ser aperfeiçoado pela Enfermagem por meio do desenvolvimento de pesquisas experimentais e clínicas 8 .…”