Systematic review of the diagnostic value of magnetic resonance imaging for early glottic carcinoma

Abstract

ObjectiveIn early glottic cancer, accurate assessment of tumor extension, including depth infiltration, is of great importance for both staging, therapeutic approach and systematic comparison of data. Our goal was to assess the diagnostic value of MRI in pre‐therapeutic staging of primary early stage (T1 and T2) glottic carcinoma.Study designSystematic review of literature.MethodsWe conducted a systematic search in Pubmed, Embase, and Scopus up to September 23, 2016. Included studies were selected and critically appraised for relevance and validity.ResultsSeven out of 938 unique articles were selected, including 64 cases. MRI over‐staged 6% and under‐staged 13% of cT1 and cT2 tumors. However, available data is heterogeneous, very limited and mainly based on subanalysis of a small amount of patients. Reported MRI protocols appear to be suboptimal for small laryngeal lesions. Diagnostic value of MRI for subtle depth infiltration or laryngeal anatomical subsites (eg, laryngeal ventricle, vocal cord, etc.) could not be assessed.ConclusionsMore studies are needed to assess the diagnostic value of MRI for small glottic tumors.

Additional Diffusion-Weighted Imaging with Background Body Signal Suppression (DWIBS) Improves Pre-Therapeutical Detection of Early-Stage (pT1a) Glottic Cancer: A Feasibility and Interobserver Reliability Study

“…Van Egmond et al conducted a systematic review of the diagnostic value of MRI for early glottic carcinoma in 2018 and reported concordance between MRI and histopathology in 81% (52 out of 64 patients). In total, 6% (4 out of 64) of tumors were over-staged, and 13% (8 out of 64) were under-staged, but available data for MRI and T1 and T2 glottic carcinomas were very limited as none of the reviewed articles solely included the defined subgroup (cT1 and cT2 glottic carcinomas), and no diagnostic values (sensitivity, specificity, PPV, and NPV) could therefore be calculated [ 12 ].…”

“…Furthermore, the development of dedicated MRI protocols for the evaluation of early-stage laryngeal cancer has not been concluded to date, as scanning protocols vary widely and are not optimal for the diagnosis of early-stage laryngeal cancer. However, implementing diffusion-weighted imaging is highly recommended by most authors [ 12 , 23 ]…”

“…Nevertheless, assessment of early-stage laryngeal cancer of the glottis by MRI remains a challenge [ 1 , 5 , 12 ] as some drawbacks of MRI persist compared to CT, including a longer acquisition time and motion artifacts requiring improved patient cooperation, a lower spatial resolution, and technical challenges related to air-tissue interfaces affecting the image quality of DWI sequences [ 5 , 13 ].…”

Multifunctional Hybrid Nanoprobe for Photoacoustic/PET/MR Imaging-Guided Photothermal Therapy of Laryngeal Cancer

“…Laryngeal cancer is one of the most common malignant tumors in otorhinolaryngology and seriously threatens the human health and the ability to speak. , Conventional clinical treatments including total laryngectomy, transoral laser microsurgery, and radiotherapy do not achieve satisfactory benefits for the most patients with larynx cancer . Moreover, these treatments have severe side effects such as loss of the ability to speak, damage to vocal folds, and negative long-term voice outcomes. − Consequently, it is of great importance and urgency to develop more precise and effective methods to diagnose and treat laryngeal cancer.…”

Clinical value of (dedicated) 3 Tesla and 7 Tesla MRI for cT1 glottic carcinoma: A feasibility study

“…A recent systematic review evaluating the diagnostic value of MRI for pre‐therapeutic staging of early glottic cancer, showed that MRI data of T1 and T2 glottic carcinoma is limited, heterogenous and based on sub analysis. Both slice thickness and the use of neck receive coils varied and was suboptimal for small laryngeal lesions.…”