Systematic Review of the Association Between Respiratory Diseases and Oral Health

Azarpazhooh, Amir; Leake, James L.

doi:10.1902/jop.2006.060010

Cited by 559 publications

(493 citation statements)

References 40 publications

(62 reference statements)

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“…Good oral health and regular professional dental cleaning has improved respiratory outcomes for patients, particularly those living in nursing homes. A recent meta-analysis has shown that periodontal disease may be associated with COPD [30]. As a large proportion of inhaled drugs are retained in the oral cavity, they may also interfere with oral physiology and the oral microbiome.…”

Section: Discussionmentioning

confidence: 99%

The Lung Microbiome in Moderate and Severe Chronic Obstructive Pulmonary Disease

Pragman¹,

Kim²,

Reilly³

et al. 2014

Annals ATS

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Chronic obstructive pulmonary disease (COPD) is an inflammatory disorder characterized by incompletely reversible airflow obstruction. Bacterial infection of the lower respiratory tract contributes to approximately 50% of COPD exacerbations. Even during periods of stable lung function, the lung harbors a community of bacteria, termed the microbiome. The role of the lung microbiome in the pathogenesis of COPD remains unknown. The COPD lung microbiome, like the healthy lung microbiome, appears to reflect microaspiration of oral microflora. Here we describe the COPD lung microbiome of 22 patients with Moderate or Severe COPD compared to 10 healthy control patients. The composition of the lung microbiomes was determined using 454 pyrosequencing of 16S rDNA found in bronchoalveolar lavage fluid. Sequences were analyzed using mothur, Ribosomal Database Project, Fast UniFrac, and Metastats. Our results showed a significant increase in microbial diversity with the development of COPD. The main phyla in all samples were Actinobacteria, Firmicutes, and Proteobacteria. Principal coordinate analyses demonstrated separation of control and COPD samples, but samples did not cluster based on disease severity. However, samples did cluster based on the use of inhaled corticosteroids and inhaled bronchodilators. Metastats analyses demonstrated an increased abundance of several oral bacteria in COPD samples.

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Section: Discussionmentioning

confidence: 99%

The Lung Microbiome in Moderate and Severe Chronic Obstructive Pulmonary Disease

Pragman¹,

Kim²,

Reilly³

et al. 2014

Annals ATS

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“…In addition to the aggravation of periodontal disease, there is a bidirectional causality between some diseases of the oral cavity and systemic morbidities, such as cardiovascular and respiratory diseases 11,13,[25][26] . The presence of oral biofilm in these patients could trigger an inflammatory response, causing a significant increase in the quantity of immunoglobulin and circulating chemical mediators of inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…During hospitalization, patients often neglect themselves, feel discouraged and even become physically or mentally incapacitated, and this may adversely affect their performance of oral hygiene care [2][3][4][5][6][7][8][9] . Oral hygiene negligence facilitates the accumulation of microorganisms in the form of biofilm, the etiological agent of oral conditions such as caries and periodontal disease 8,[10][11][12][13][14] .…”

Section: Introductionmentioning

confidence: 99%

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The impact of hospitalization on periodontal health status: an observational study

Lages

Dutra

Lima

et al. 2017

RGO, Rev. Gaúch. Odontol.

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Objective To evaluate the impact of hospitalization on the periodontal status of patients admitted to a private hospital. Methods A sample of 41 patients answered a questionnaire on oral hygiene habits before and after hospitalization. An examiner measured the Periodontal Screening and Recording ratio (PSR) within 24 hours after hospitalization (T0), after five (T1) and after ten days of hospital admission (T2). Results 47 RESUMO ObjetivoAvaliar o impacto da internação hospitalar sobre a condição periodontal de pacientes em um hospital privado. MétodosA amostra de 41 pacientes respondeu questionário sobre hábitos de higiene bucal antes e após a internação. Um examinador mensurou o índice Periodontal Screening and Recording (PSR) no início, cinco e dez dias a partir da admissão hospitalar. ResultadosNenhum paciente recebeu orientação sobre higiene bucal por profissionais do hospital. Após 5 dias do exame inicial, 58,8% dos pacientes sadios apresentaram sangramento à sondagem e 16,7% dos pacientes com sangramento apresentaram cálculo dental; e 10 dias depois, 70,0% dos pacientes sadios apresentaram sangramento gengival e 57,1% daqueles que já tinham sangramento gengival apresentaram cálculo dental. Houve um aumento das necessidades de tratamento. ConclusãoA condição periodontal de pacientes internados agravou-se com o decorrer do tempo de internação e, consequentemente, houve um aumento da necessidade de tratamento. Isso desperta a atenção para a importância dos cuidados de higiene bucal no hospital.

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“…Further, there is evidence for direct links between oral health and general health. Systematic reviews concluded that poor oral hygiene and periodontal disease are risk factors for pneumonia, and possibly also for chronic obstructive pulmonary disease (Azarpazhooh and Leake 2006;Sjögren et al 2008), and that periodontal disease adversely affects diabetes outcomes (Borgnakke et al 2013). …”

Section: Introductionmentioning

confidence: 99%

A Life Course Perspective on Health Trajectories and Transitions

Burton-Jeangros

Cullati

Sacker

et al. 2015

Life Course Research and Social Policies

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Life course research has been developing quickly these last decades for good reasons. Life course approaches focus on essential questions about individuals' trajectories, longitudinal analyses, cross-fertilization across disciplines like lifespan psychology, developmental social psychology, sociology of the life course, social demography, socio-economics, social history. Life course is also at the crossroads of several fields of specialization like family and social relationships, migration, education, professional training and employment, and health. This Series invites academic scholars to present theoretical, methodological, and empirical advances in the analysis of the life course, and to elaborate on possible implications for society and social policies applications.More information about this series at

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Systematic Review of the Association Between Respiratory Diseases and Oral Health

Cited by 559 publications

References 40 publications

The Lung Microbiome in Moderate and Severe Chronic Obstructive Pulmonary Disease

The Lung Microbiome in Moderate and Severe Chronic Obstructive Pulmonary Disease

The impact of hospitalization on periodontal health status: an observational study

A Life Course Perspective on Health Trajectories and Transitions

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