Systematic Review of Systemic Corticosteroids for Treatment of Organizing Pneumonia

Cendon, Laia; Codern, Albert Rafecas; Rosa, David de la; Castellví, Iván; Spagnolo, Paolo; Castillo, Diego

doi:10.1016/j.opresp.2022.100211

Cited by 2 publications

(3 citation statements)

References 131 publications

(128 reference statements)

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“…Brucellosis [8] and aspergillosis [4,7] were also considered but excluded with advanced testing, as suggested by He et al [8] and Lim et al [7]. A combination of antibiotics and corticosteroids led to clinical improvement, as suggested by Cendon et al [1].…”

Section: Discussionmentioning

confidence: 99%

“…Community-acquired pneumonia (CAP) typically presents with a well-defined constellation of symptoms and responds favorably to antibiotics. However, a subset of patients deviates from this classic presentation, exhibiting a prolonged and complicated course of antibiotics and corticosteroids [ 1 , 2 ] that necessitates a more nuanced diagnostic approach [ 3 , 4 ]. This report describes the case of a 41-year-old woman with no significant past medical history who presented with a 3.5-month history of fever, generalized weakness, productive cough, burning micturition, and significant weight loss.…”

Section: Introductionmentioning

confidence: 99%

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A Diagnostic Dilemma: A Case of Complicated Pneumonia With Pyelonephritis and Subclinical Myocarditis

Goswami,

Singh,

Sharma

et al. 2024

Cureus

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A 41-year-old woman presented with a 3.5-month history of fever, weakness, productive cough, and burning micturition along with generalized weakness and significant weight loss. Chest X-ray revealed bilateral infiltrates and bilateral pleural effusion, and the workup suggested community-acquired pneumonia (CAP). However, the course was complicated by persistent fevers, elevated inflammatory markers, elevated Nterminal pro-B-type natriuretic peptide (NT-proBNP), and pelvic fluid collection.Extensive investigations, including bronchoscopy and lung biopsy, failed to identify a specific pathogen. Pulmonary vasculitis and lymphoma were ruled out. Antibiotic and corticosteroid therapy resulted in clinical improvement. While the cause remains unknown, brucellosis and aspergillosis were considered but ruled out with advanced testing. The underlying etiology remains elusive, highlighting the diagnostic challenges in CAP with atypical presentations.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Diagnostic Dilemma: A Case of Complicated Pneumonia With Pyelonephritis and Subclinical Myocarditis

Goswami,

Singh,

Sharma

et al. 2024

Cureus

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“…Notably, pathology in both cases can be altered if treated with steroids before sampling. Patients with COP do require a prolonged course of steroids and often have a recurrence of symptoms [ 8 ] while patients with acute IEP show complete resolution at the end of their steroid treatment [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Cryptogenic Organizing Pneumonia and Idiopathic Eosinophilic Pneumonia: A Case Report of Clinically Identical Entities

Buddhavarapu¹,

Dhillon²,

Grewal³

et al. 2023

Cureus

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Cryptogenic organizing pneumonia (COP) and idiopathic eosinophilic pneumonia (IEP) are two forms of diffuse interstitial lung diseases (ILD) that lead to a rapid respiratory decline in young patients. Both conditions presented with similar clinical and radiological findings, making a clinical diagnosis challenging. They are both considered diagnoses of exclusion, and the treatment for both conditions is high-dose corticosteroids, leading to a quick recovery. Pathological specimens are often required prior to initiating appropriate treatment, leading to significant delays in appropriate therapy and a poorer prognosis. In this case report, we suggest that clinical pearls can be used to establish either diagnosis earlier, which leads to earlier treatment and better outcomes. Our patient presented with an acute respiratory distress syndrome (ARDS) picture, bilateral interstitial infiltrates with peripheral predominance, eosinophilia, and a negative initial infectious and cardiac workup. Based on these findings, we had a high initial suspicion that either COP or IEP was present. Our patient had a bronchoscopy done and was promptly started on steroid therapy soon after, which led to rapid clinical improvement. Pathological specimens were inconclusive, but the patient continued to improve, thereby confirming the presence of either form of ILD. The patient was subsequently discharged home with oxygen and recommended to follow up with a pulmonologist for further outpatient testing and management.

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Systematic Review of Systemic Corticosteroids for Treatment of Organizing Pneumonia

Cited by 2 publications

References 131 publications

A Diagnostic Dilemma: A Case of Complicated Pneumonia With Pyelonephritis and Subclinical Myocarditis

A Diagnostic Dilemma: A Case of Complicated Pneumonia With Pyelonephritis and Subclinical Myocarditis

Cryptogenic Organizing Pneumonia and Idiopathic Eosinophilic Pneumonia: A Case Report of Clinically Identical Entities

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