Systematic Review of Physical Activity Trajectories and Mortality in Patients With Coronary Artery Disease

PPBP gene as a biomarker for coronary heart disease risk in postmenopausal Thai women

“…(2) the gene profile was obtained and applied from male samples using next-generation sequencing analysis ( Maneerat et al, 2016 , 2017 ). The data might thus not be applicable in women, because of sex differences, for instance in innate immunity ( Casimir et al, 2010 ; Gupta et al, 2020 ; Maianski et al, 2004 ; Stubelius et al, 2017 ), various risk factors ( Anand et al, 2008 ; Gonzalez-Jaramillo et al, 2022 ; Sucato et al, 2022 ), and plaque morphology in coronary atherosclerosis ( Sato et al, 2022 ). Further studies with larger sample size are therefore needed to validate the findings using sex-specific gene profiles to select appropriate biomarkers for females.…”

“…Atherogenesis and coronary heart disease (CHD) involve a long preclinical process. Complicated risk factors for CHD have been identified in both women and men without familial hypercholesterolemia, including behavioral, dietary, and lifestyle factors such as smoking, physical activity, dietary fat intake, exogenous infections, changes in endogenous blood constituents such as lipid and lipoprotein particles, inflammation and coagulation proteins, intermediate metabolites, and oxidant markers of stress, obesity, hypertension, and diabetes mellitus ( Anand et al, 2008 ; Gonzalez-Jaramillo et al, 2022 ; Sucato et al, 2022 ). Sex is also an important factor affecting the development of CVD.…”

Late-life physical activity changes after a cardiovascular event: can we reduce mortality risks?

“…A recent systematic review suggests that patients with coronary heart disease who maintain or engage in physical activity can significantly reduce mortality risks compared to those inactive over time 2. Changes in physical activity describe trajectories that have the potential of better defining individual risk profiles compared to single-time assessments 2. Recently, growing interest has been drawn to the possibility of achieving cardiovascular benefits by engaging in physical activity also in late-life 3 4.…”

Domestic Physical Activity: An Overlooked Risk-Modifier for Incident Hypertension?

“…Physical activity is associated with improved mental and physical quality of life, 1 blood pressure control and cardiovascular health, 2, 3 cancer prevention, 2 cancer survival, 4 and all-cause mortality. 5,6 Physiologically, physical activity's beneficial effects include skeletal and cardiac muscle hypertrophy, increased mitochondrial activity, improvements in maximum ventilation capacity, and increase in capillary volume with reduction in peripheral vascular resistance. 7 Physical activity is thus a foundational tenet of many preventive guidelines, including current recommendations for blood pressure management.…”

“…on incident hypertension in 1311 African-Americans, but found no benefit from home/life ("domestic") physical activity in adjusted models. 11 The analysis was arguably incomplete, however, since the study assessed overall domestic activity of each participant as a single ordinal variable (1)(2)(3)(4)(5). The potential impact of duration or relative intensity of different domestic tasks was therefore limited.…”