Systematic Review of Ozone Effects on Human Lung Function, 2013 Through 2020

Holm, Stephanie M.; Balmes, John R.

doi:10.1016/j.chest.2021.07.2170

Cited by 56 publications

(38 citation statements)

References 55 publications

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“…The range of magnitude in the association we found between short-term O 3 and evening FEV 1 is comparable to previous studies, with a lower limit of −5.2% expected reduction in %predicted FEV 1 (−2.65 [−5.19, −0.10]). For example, a previous literature review reported that short-term O 3 exposure was associated with a wide range of reduction in %predicted FEV 1 in children (−0.01% to −9% reduction per 10 ppb change in O 3 ), for periods ranging from 1 day to 2 weeks [ 37 ]. Similarly, expected changes as large as −9.3% reduction in morning %predicted FEV 1 and −9.3% reduction in morning %predicted PEF were seen with lag 1 traffic-related NO x exposure (lower 95% CI limit, Supplementary Tables S4 and S5 ).…”

Section: Discussionmentioning

confidence: 99%

Daily Associations of Air Pollution and Pediatric Asthma Risk Using the Biomedical REAI-Time Health Evaluation (BREATHE) Kit

Hao

Eckel

Hosseini

et al. 2022

IJERPH

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Background: Exposure to air pollution is associated with acute pediatric asthma exacerbations, including reduced lung function, rescue medication usage, and increased symptoms; however, most studies are limited in investigating longitudinal changes in these acute effects. This study aims to investigate the effects of daily air pollution exposure on acute pediatric asthma exacerbation risk using a repeated-measures design. Methods: We conducted a panel study of 40 children aged 8–16 years with moderate-to-severe asthma. We deployed the Biomedical REAI-Time Health Evaluation (BREATHE) Kit developed in the Los Angeles PRISMS Center to continuously monitor personal exposure to particulate matter of aerodynamic diameter < 2.5 µm (PM2.5), relative humidity and temperature, geolocation (GPS), and asthma outcomes including lung function, medication use, and symptoms for 14 days. Hourly ambient (PM2.5, nitrogen dioxide (NO2), ozone (O3)) and traffic-related (nitrogen oxides (NOx) and PM2.5) air pollution exposures were modeled based on location. We used mixed-effects models to examine the association of same day and lagged (up to 2 days) exposures with daily changes in % predicted forced expiratory volume in 1 s (FEV1) and % predicted peak expiratory flow (PEF), count of rescue inhaler puffs, and symptoms. Results: Participants were on average 12.0 years old (range: 8.4–16.8) with mean (SD) morning %predicted FEV1 of 67.9% (17.3%) and PEF of 69.1% (18.4%) and 1.4 (3.5) puffs per day of rescue inhaler use. Participants reported chest tightness, wheeze, trouble breathing, and cough symptoms on 36.4%, 17.5%, 32.3%, and 42.9%, respectively (n = 217 person-days). One SD increase in previous day O3 exposure was associated with reduced morning (beta [95% CI]: −4.11 [−6.86, −1.36]), evening (−2.65 [−5.19, −0.10]) and daily average %predicted FEV1 (−3.45 [−6.42, −0.47]). Daily (lag 0) exposure to traffic-related PM2.5 exposure was associated with reduced morning %predicted PEF (−3.97 [−7.69, −0.26]) and greater odds of “feeling scared of trouble breathing” symptom (odds ratio [95% CI]: 1.83 [1.03, 3.24]). Exposure to ambient O3, NOx, and NO was significantly associated with increased rescue inhaler use (rate ratio [95% CI]: O3 1.52 [1.02, 2.27], NOx 1.61 [1.23, 2.11], NO 1.80 [1.37, 2.35]). Conclusions: We found significant associations of air pollution exposure with lung function, rescue inhaler use, and “feeling scared of trouble breathing.” Our study demonstrates the potential of informatics and wearable sensor technologies at collecting highly resolved, contextual, and personal exposure data for understanding acute pediatric asthma triggers.

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Section: Discussionmentioning

confidence: 99%

Daily Associations of Air Pollution and Pediatric Asthma Risk Using the Biomedical REAI-Time Health Evaluation (BREATHE) Kit

Hao

Eckel

Hosseini

et al. 2022

IJERPH

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“…First, VOCs can undergo photochemical reactions with nitrogen oxides (NO x ) and ultraviolet (UV) radiation to produce ground-level O 3 [7]. Exposure to groundlevel O 3 has been associated with decreased lung function [8] and pre-term births [9]. Secondly, VOCs emitted from biogenic and anthropogenic sources can react to form secondary organic aerosols (SOAs) [10,11], which contribute to PM 2.5 and smog [12,13].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Volatile Organic Compound Concentrations in Ambient Air among Different Source Areas around Khon Kaen, Thailand

et al. 2021

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Volatile organic compounds (VOCs) are a complex group of chemicals that pose a direct risk to human health. They also lead to the formation of other air pollution constituents, including fine particulate matter (PM2.5) and ground level ozone (O₃). The ambient air concentrations of 19 VOCs were measured using multi-day 24 h sampling at two urban sites and two rural sites in the area of Khon Kaen, Thailand. Results showed that most VOCs were at concentrations considered acceptable according to the 24 h average standards established by the Thai Pollution Control Department. The VOC acrolein, however, was detected at concentrations (0.69–1.15 μg/m3) in excess of the 24 h average standard (0.55 μg/m3). Two other VOCs, benzene and 1,3-butadiene, were also detected at elevated levels (1.73–2.75 and 0.18–0.40 μg/m3, respectively) that indicated the potential to exceed the 1-year average standard. VOC concentrations were highest in the urban market monitoring site, suggesting that vehicle exhaust and food preparation using cooking oil at high temperatures may have been potential sources of the elevated VOCs.

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“…Ozone is perhaps the best studied air pollutant in terms of acute respiratory effects, and review of recent evidence confirms that short-term exposure is associated with acute decrements in lung function ( 1 ). In fact, the National Ambient Air Quality Standard for ozone promulgated by the U.S. Environmental Protection Agency is based primarily on evidence from multiple controlled human-exposure studies conducted over the past several decades showing acute decrements in lung function ( 2 ).…”

mentioning

confidence: 99%

“…In fact, the National Ambient Air Quality Standard for ozone promulgated by the U.S. Environmental Protection Agency is based primarily on evidence from multiple controlled human-exposure studies conducted over the past several decades showing acute decrements in lung function ( 2 ). Multihour ozone concentrations of 80 ppb or higher consistently produce significant decreases in FEV 1 and FVC in healthy adults that typically resolve within 24 hours ( 1 , 2 ). Multiple epidemiological studies have also demonstrated acute decrements in spirometric lung function with real-world exposures during exercise ( 1 – 4 ).…”

mentioning

confidence: 99%

“…Multihour ozone concentrations of 80 ppb or higher consistently produce significant decreases in FEV 1 and FVC in healthy adults that typically resolve within 24 hours ( 1 , 2 ). Multiple epidemiological studies have also demonstrated acute decrements in spirometric lung function with real-world exposures during exercise ( 1 – 4 ). Despite the robust human experimental and epidemiological evidence of the acute effects of short-term ozone exposure on lung function, the evidence for chronic effects of long-term exposure to higher concentrations of ozone is relatively sparse and less clear.…”

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confidence: 99%

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