Systematic Review of Metabolic Syndrome Biomarkers: A Panel for Early Detection, Management, and Risk Stratification in the West Virginian Population

Srikanthan, Krithika; Feyh, Andrew; Visweshwar, Haresh; Shapiro, Joseph I.; Sodhi, Komal

doi:10.7150/ijms.13800

Cited by 367 publications

(362 citation statements)

References 147 publications

(122 reference statements)

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“…Obesity is not sufficient to characterise the risk, as not all the obese population is metabolically obese (Guo & Garvey, 2016;Gherman et al, 2010). Therefore, assessing the appropriate screening methods for the young nonobese persons needs further research (Srikanthan et al, 2016).…”

Section: Problem Statementmentioning

confidence: 99%

Atherogenic Plasma Index in a Young Non-Obese Caucasian Population

Oțelea¹

2018

The European Proceedings of Social and Behavioural Sciences

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Cardiovascular risk is based on age, gender, smoking, systolic blood pressure and total cholesterol.Although it is well documented that the atherosclerosis process starts early in life, the risk is very clearly defined only for fatal events and only for persons above 40 years old. Besides the Guidelines for the Management of Dyslipidaemias, other factors such as atherogenic plasma index (AIP) or adipokine levels have certain predictive information about this risk. The aim of our study was to assess the gender differences in AIP in a young non-obese adult population. We selected 85 young adults without a diagnosis of metabolic syndrome or related medical conditions. The metabolic syndrome components were measured and those (2 subjects) with 3 established metabolic syndrome criteria were excluded. The average AIP value on the whole group was 0.07. When stratifying the risk according to the AIP value, the majority of the participants were in the low risk range (51 participants representing 61.4% of the total), 18 (21.6%) were included in the high risk, and 15 (18%), in the medium risk category. The average AIP in women's group was 0.02, and in men's group, 0.18 (p<0.001). Our preliminary results suggest that, for screening purposes, the AIP threshold should be different according to gender. To confirm this finding, a large longitudinal study is needed.

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Section: Problem Statementmentioning

confidence: 99%

Atherogenic Plasma Index in a Young Non-Obese Caucasian Population

Oțelea¹

2018

The European Proceedings of Social and Behavioural Sciences

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“…More than 50% of diabetes mellitus patients experience failure to control blood glucose levels that lead to HbA1c levels abnormalities (>7%) [9]. High blood glucose or HbA1c levels causes oxidative stress that damages blood vessels and triggers vascular endothelial death [10,11]. HbA1c is formed from a bond of glucose with an amide group on the valine amino acid at the end of the Hb globulin beta chain.…”

Section: Ipcuad2017mentioning

confidence: 99%

The efficacy of black cumin seed (Nigella sativa) oil and hypoglycemic drug combination to reduce HbA1c level in patients with metabolic syndrome risk

Rachman

Akrom

Darmawan

2017

IOP Conf. Ser.: Mater. Sci. Eng.

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The efficacy of black cumin seed (Nigella sativa) oil and hypoglycemic drug combination to reduce HbA1c level in patients with metabolic syndrome risk Abstract. Metabolic syndrome is a conditions caused by metabolic abnormalities include central obesity, atherogenic dyslipidemia, hypertension, and insulin resistance. HbA1c examination is required to study the long-term glycemic status and to prevent diabetic complications of metabolic syndrome. The purpose of this study is to determine the efficacy of black cumin seed (Nigella sativa) oil and hypoglycemic drug combination to reduce HbA1c level in patients with metabolic syndrome risk. This research performed using an experimental randomized single -blind controlled trial design. A total of 99 outpatients at the Jetis I Public Health Center, Yogyakarta, Indonesia with metabolic syndrome risk were divided into three groups: The control group received placebo and two treatment groups received black seed oil orally at dose of 1.5 mL/day and 3 mL/day, respectively, for 20 days. The clinical conditions such as blood pressure, pulse rate, BMI, blood glucose serum and HbA1c levels were examined on day 0 and 21. The results obtained were analyzed with one-way ANOVA test. The mean of HbA1c levels of all groups before treatment was higher than the normal values and there was no significant difference in HbA1c value on day 0. Administration of 1.5 and 3 mL/day of black seed oil for 20 days decreased (p<0.05) HbA1c levels. It can be concluded that administration of black cumin seed oil and hypoglycemic drug combination for 20 days in patients at risk of metabolic syndrome may reduce to HbA1c levels.

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“…Masno tkivo funkcioniše i kao endokrini organ, zbog sposobnosti adipocita da produkuju brojne biološki aktivne supstance -adipocitokine. Povećanje broja adipocita u organizmu gojaznih osoba dovodi do veće produkcije adipokina i pogoduje razvoju metaboličkog sindroma [3]. Metabolički sindrom karakteriše prisustvo više povezanih metaboličkih poremećaja u humanom organizmu, poremećaj regulacije metabolizma lipida (dislipidemija), hiperglikemija, neosetljivost na insulin, povećan krvni pritisak i abdominalna (centralna) gojaznost.…”

unclassified

Examination of myeloperoxidase activity, as an indicator of inflammation in obese participants with metabolic syndrome

Matic¹,

Puhalo-Sladoje²,

Kisić³

et al. 2016

Praxis Med

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Gojaznost humanog organizma je složen metabolički poremećaj koji predstavlja jedan od najčešćih savremenih zdravstvenih problema. Brojna istraživanja ukazuju na udruženost hronične inflamacije niskog stepena i gojaznosti. Mijeloperoksidaza (MPO) i njeni reaktivni oksidanti učestvuju u oštećenju tkiva tokom inflamatornih procesa u humanom organizmu. Cilj istraživanja bilo je ispitivanje aktivnosti enzima mijeloperoksidaze u serumu gojaznih i ispitanika sa metaboličkim sindromom i testiranje povezanosti aktivnosti MPO i drugih pokazatelja zapaljenja u krvi ispitanika. Ispitanici su na osnovu antropometrijskih parametara i biohemijskih pokazatelja podeljeni u tri grupe: normalno uhranjeni (n=30), ispitanici sa abdominalnom gojaznošću (n=30) i ispitanici sa metaboličkim sindromom (n=30). U serumu ispitanika određivana je hlorinišuća aktivnost MPO spektrofotometrijski. Tokom ispitivanja utvrđene su značajne razlike u aktivnosti MPO kod sve tri grupe ispitanika i to najveća aktivnost izmerena je kod ispitanika sa metaboličkim sindromom (p<0.001). Utvrđena je pozitivna korelacija između aktivnost MPO i aterogenog indeksa, kao i između MPO i koncentracije LDL-holesterola, dok je negativna povezanost utvrđena između MPO i koncentracije HDL-holesterola. Ispitivanje je pokazalo da aktivnost MPO progresivno raste sa gojaznošću i metaboličkim sindromom. Dobijeni rezultati ukazju da MPO može biti od značaja u patofiziološkim mehanizmima koji dovode do razvoja komplikacija kod gojaznosti i metaboličkog sindroma.Ključne reči: mijeloperoksidaza, metabolički sindrom, inflamacija, gojaznost, dislipidemija. UVODGojaznost je složen metabolički poremećaj koji predstavlja jedan od najčešćih savremenih zdravstvenih problema. Prema definiciji Svetske zdravstvene organizacije gojaznost karakteriše indeks telesne mase (engl. Body Mass Index, BMI) preko 30 kg/m2 [1]. Gojaznost je povezana sa razvojem najčešćih savremenih humanih bolesti, kao što su koronarna srčana bolest, hipertenzija, diabetes mellitus tip 2 i dr. Brojna istraživanja ukazuju na udruženost perzistentne hronične inflamacije niskog stepena i gojaznosti [2]. Masno tkivo funkcioniše i kao endokrini organ, zbog sposobnosti adipocita da produkuju brojne biološki aktivne supstance -adipocitokine. Povećanje broja adipocita u organizmu gojaznih osoba dovodi do veće produkcije adipokina i pogoduje razvoju metaboličkog sindroma [3]. Metabolički sindrom karakteriše prisustvo više povezanih metaboličkih poremećaja u humanom organizmu, poremećaj regulacije metabolizma lipida (dislipidemija), hiperglikemija, neosetljivost na insulin, povećan krvni pritisak i abdominalna (centralna) gojaznost. Pomenuti metabolički poremećaji, kao i kod gojaznosti, predstavljaju značajne faktore rizika za pojavu brojnih komplikacija. Mijeloperoksidaza (MPO; E.C. 1.11.1.7.) jedan je od najzastupljenijih proteina u humanim neutrofilnim leukocitima i manje zastupljen u monocitima i tkivnim makrofagima [4]. Mijeloperoksidaza koja se nalazi u azurofilnim granulama neutrofila u toku aktivacije prelazi u fagocit...

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Systematic Review of Metabolic Syndrome Biomarkers: A Panel for Early Detection, Management, and Risk Stratification in the West Virginian Population

Cited by 367 publications

References 147 publications

Atherogenic Plasma Index in a Young Non-Obese Caucasian Population

Atherogenic Plasma Index in a Young Non-Obese Caucasian Population

The efficacy of black cumin seed (Nigella sativa) oil and hypoglycemic drug combination to reduce HbA1c level in patients with metabolic syndrome risk

Examination of myeloperoxidase activity, as an indicator of inflammation in obese participants with metabolic syndrome

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