Systematic review of innovative ablative therapies for the treatment of locally advanced pancreatic cancer

Abstract

Ablative therapies in patients with LAPC appear to be feasible and safe.

Time-dependent impact of irreversible electroporation on pancreas, liver, blood vessels and nerves: a systematic review of experimental studies

“…electric field strength, pulse number and duration) on pathological outcomes needs further examination. Several animal studies have aimed to clarify the mechanisms of IRE using a wide range of settings, and by comparing the effects of IRE with alternative techniques [20][21][22][23]. The main limitation of these studies is that specimen evaluation was performed at varying times after IRE-ablation.…”

“…The main limitation of these studies is that specimen evaluation was performed at varying times after IRE-ablation. This may be problematic since cell death is a dynamic process by definition (23), and the question to which extent the time of histological evaluation determines the outcomes remains unanswered.…”

Current therapeutic strategies for advanced pancreatic cancer: A review for clinicians

“…As an example, in a single centre institution experience, the authors reported a median OS of 18.4 mo and median PFS of 9.8 mo in 88 patients affected by LAPC and BRPC treated with SBRT (2-30 Gy in five fractions on the planning target volume) with an acceptable toxicity profile (3.4% of > G3 gastrointestinal toxicity) [86] . Furthermore, SBRT led to improved pain control in five out of six studies in which this outcome has been evaluated [87] . Moreover, as previously mentioned, SBRT can be delivered in association with chemotherapy with interesting preliminary evidence of activity (e.g., gemcitabine).…”

“…It can be administered with continuous or pulsed modality. HIFU doesn't need the placement of a needle and it is characterized by a low rate of adverse events [87] . In a recent trial of HIFU, administered in addition chemotherapy or chemoradiotherapy to 30 patients with stage Ⅲ/Ⅳ PC, the rate of symptom relief effect was 66.7% and the disease control-rate was 86% (mainly stable disease).…”

Electroporation: characteristics and therapeutic application of the method (a review)

“…Они пришли к выводу о высокой эффективности, простоте и доступности данного метода при указанной патологии. Другие авторы также указывают на эффективность электропорационной терапии при раке поджелудочной железы, в том числе и при его нерезектабельных формах [43][44][45].…”