Systematic review of hyperbaric oxygen therapy for the treatment of non-neurological soft tissue radiation-related injuries

Hoggan, B.L.; Cameron, A Scott

doi:10.1007/s00520-014-2198-z

Cited by 29 publications

(28 citation statements)

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“…Systematic reviews of HBOT and cancer have described the use of HBOT in patients with malignancy (Daruwalla and Christophi, 2006;Hoggan and Cameron, 2014;Mayer et al, 2005;Moen and Stuhr, 2012). However, several unsolved questions remain connected with HBOT treatment, including severe DNA damage and genetic instability leading to reactivation or augmentation of existing cancer, development of fragile and porous capillaries and associated higher chance of metastasis, initiating aneuplody causing delay in DNA repair of surrounding normal or stromal cells.…”

Section: Abstract: Angiogenesis Chorioallantoic Membrane Hyperbarimentioning

confidence: 99%

Angiogenesis and hyperbaric oxygen in the chick embryo chorioallantoic membrane

et al. 2015

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Hyperbaric Oxygen Therapy (HBOT) is increasingly applied in different areas of medical practice. The oxy-hyperbarism effects are not well understood in cancer malignancy. One unique feature of cancer is the presence of hypoxic regions that are insensitive to conventional therapies. It is possible to alter the hypoxic state and produce reactive oxygen species for better treatment outcome by HBOT. In the present study, we determined the effects of HBOT on angiogenesis, a signature of cancer progression, by using the chick chorioallantoic membrane (CAM) in vivo assy. CAMs were exposed to 2.0 ATA (atmospheres absolute) for 30 min of hyperbaric oxygen on the 6 th and 7 th days of incubation (ED6, ED7). On the 10-11 th day of incubation, CAMs were excised from eggs, fixed and analysed using APERIO ImageScope software. HBOT outcomes were evaluated quantifying the volumetric area occupied by blood vessels and calculating the number of blood vessel ramifications. Results indicated that CAMs treated at ED6 and ED7 had a significantly higher CAM vascularization and an increased number of blood vessel ramifications (+82% higher for ED6) compared to untreated CAMs (ED6=63.3±2.5 and ED7=57.7±5.5 vs. CTRL=34.7±2.5). Thus, HBOT induces an angiogenic response in treated CAMs through a classic sprouting mechanism.

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Section: Abstract: Angiogenesis Chorioallantoic Membrane Hyperbarimentioning

confidence: 99%

Angiogenesis and hyperbaric oxygen in the chick embryo chorioallantoic membrane

et al. 2015

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“…However, the roles of HBO as an adjunctive therapy for tumors remains controversial. Some previous studies suggest that HBO therapy may improve postoperative outcome and outcome of radiotherapy and chemotherapy, especially proving beneficial for the treatment of radiotherapy (4,5). A combinatorial approach using chemotherapeutic drugs with HBO may enhance sensitivity of tumor cells to chemotherapeutic agents (6,7) and the application of HBO in chemotherapy for malignant lymphoma, brain tumor, lung cancer, gastric cancer and breast cancer may increase chemotherapeutic efficacy while decreasing treatment related toxicity (8).…”

Section: Introductionmentioning

confidence: 99%

Effects of hyperbaric oxygen treatment on gastric cancer cell line SGC7901

Ruan

Wang

et al. 2017

Biomedical Reports

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Abstract. Hyperbaric oxygen (HBO) has been previously identified as an effective adjunct treatment option for the management of brain injury, diabetic ulcers and chronic wounds. However, the roles of HBO as an adjunctive therapy for tumors remain controversial. The present research project was performed to explore the effects of HBO treatment on proliferation, autophagy and endoplasmic reticulum stress response of the gastric cancer cell line, SGC7901. The present study demonstrated that, after subjecting SGC7901 cells to HBO treatment, the increase in cell proliferation was significant, compared with that of the control group. In addition, there was a significant increase in LC3-phosphatidylethanolamine conjugate (LC3-II) level, as well as binding immunoglobulin protein level, and a significant decrease in CCAAT-enhancer-binding protein homologous protein level. These suggested that hyperbaric oxygen treatment alone may promote proliferation and cell survival of gastric cancer cell SGC7901, and inhibit apoptosis through regulating cell autophagy and oxidative stress. IntroductionWidely used in the clinic, hyperbaric oxygen (HBO) treatment has be shown to be an effective adjunct to management of brain injury (1), diabetic ulcers (2) and chronic wounds (3). However, the roles of HBO as an adjunctive therapy for tumors remains controversial. Some previous studies suggest that HBO therapy may improve postoperative outcome and outcome of radiotherapy and chemotherapy, especially proving beneficial for the treatment of radiotherapy (4,5). A combinatorial approach using chemotherapeutic drugs with HBO may enhance sensitivity of tumor cells to chemotherapeutic agents (6,7) and the application of HBO in chemotherapy for malignant lymphoma, brain tumor, lung cancer, gastric cancer and breast cancer may increase chemotherapeutic efficacy while decreasing treatment related toxicity (8). However, HBO treatment alone may stimulate the proliferation of tumor tissues (9). Other studies indicate that cancer cells in hypoxic conditions are more likely to metastasize and thus be more deadly (10-12). Meanwhile, hypoxic cells undergo a high rate of mutation to become a treatment-resistant genotype, and HBO treatment may improve it (13). The current study is to explore the effects of hyperbaric oxygen treatment alone on proliferation, autophagy and oxidative stress response of gastric cancer SGC7901 cells. Materials and methodsCell culture. Gastric cancer SGC7901 cell lines were purchased from the American Type Culture Collection (Manassas, VA, USA), inoculated in Dulbecco's modified Eagle's (high glucose) culture medium (Gibco; Thermo Fisher Scientific, Inc., Waltham, MA, USA) with 10% fetal bovine serum (Clark Bioscience, Richmond, VA, USA) and cultured in a 5% CO 2 incubator at 37˚C. HBO treatment.Prior to the experiment, the hyperbaric chamber was disinfected using UV techniques for 20 min, and cleaned using pure oxygen for 10 min. The cells were placed flat in the chamber under aseptic conditions for 90 min each time. The press...

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“…5 Pharmacological experiments have demonstrated that sanguis draconis produces the following effects: (1) improvements to blood circulation; (2) powerful anti-inflammatory, analgesic, and immuneimproving effects caused by saponins within sanguis draconis; (3) sterilization; and (4) the promotion of wound healing by stimulating keratinocyte cell migration, thereby promoting fibroblast cell migration and the proliferation of vascular endothelial cells. 3,4,6,7 In this article, we report the observed medicinal effects of sanguis draconis on the treatment of chronic pressure ulcer with tunneling.…”

Section: Herbal Pharmacologymentioning

confidence: 95%

“…To promote wound healing, an evidencebased approach that showed oxygen therapy promoted wound healing was adopted, in which the wound was treated with sanguis draconis in combination with local oxygen therapy. 6 At each change of the topical wound dressing, normal saline was used to wash the sanguis draconis powder from the wound, and the wound was then cleaned with hydrogen peroxide and thoroughly irrigated with pulses of normal saline. Local high-flow oxygen therapy (with the oxygen flow regulated to 6-8 L/min) was applied to the wound for 30 minutes.…”

Section: Specific Practicesmentioning

confidence: 99%

Sanguis Draconis (Daemonorops draco)

Shu

Zhang²,

Hua³

et al. 2015

Holistic Nursing Practice

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Pressure ulcers are a frequently encountered difficulty in clinical nursing care. In cases of pressure ulcers, continued pressure on soft tissue leads to pathological processes in affected tissues that include ischemia and hypoxia, nutritional and metabolic disorders, and degeneration and necrosis. Pressure ulcers are a common clinical complication. In February 2013, our department admitted a patient with Parkinson's disease who suffered from a chronic pressure ulcer with tunneling. This patient was given an integrative therapy treatment protocol that consisted of external applications of a phytomedicine called sanguis draconis, combined with a series of conventional treatments, including local oxygen therapy, custom-built vacuum aspiration, and anti-infection therapies. The patient's integrative treatment program resulted in complete amelioration of the pressure ulceration. The following sections describe the nursing experiences associated with this case study.

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Systematic review of hyperbaric oxygen therapy for the treatment of non-neurological soft tissue radiation-related injuries

Cited by 29 publications

References 50 publications

Angiogenesis and hyperbaric oxygen in the chick embryo chorioallantoic membrane

Angiogenesis and hyperbaric oxygen in the chick embryo chorioallantoic membrane

Effects of hyperbaric oxygen treatment on gastric cancer cell line SGC7901

Sanguis Draconis (Daemonorops draco)

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