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AbstractIntroduction: The appropriate management of patients with osteoporosis and the rational use of antibiotics are growing concerns in Pakistan. The first step to improve patient care is to understand current prescribing patterns and the rationale behind these patterns. Aim: To assesses utilisation patterns, prescribing behaviour and the potential rationale among a range of medicines including bisphosphonates and antibiotics. Subsequently, use the findings to suggest potential future policies for all key stakeholders to improve patient care in the future. Methodology: A questionnaire based, cross-sectional study in both private and public health care facilities in Pakistan, conducted between January 2011 and December 2012, involving 438 physicians and15824 prescriptions. The second study involved 9984 outpatient prescriptions, 127 in-patient cases and over 100 prescribers and dispensers. Results: There was adequate history taking and examinations in approximately half of the physicians surveyed, with prescribing typically taking into account issues such as disease severity (84% of respondents) and the socioeconomic status of patients (53%). Prescribing of bisphosphonates was common certainly compared to medicines