Systematic review of ethnomedicine, phytochemistry, and pharmacology of Cyperi Rhizoma

Abstract

Cyperi Rhizoma (CR) is the dry rhizome of Cyperus rotundus L., a Cyperaceae plant. It has a long history of clinical medication and is known as the “holy medicine” of gynecology. CR smells sweet and bitter. It has the effect of soothing the liver and relieving depression, regulating qi, regulating meridian and relieving pain. It can be used to treat liver qi stagnation, chest pain, spleen and stomach qi stagnation, hernia pain, irregular menstruation and other diseases. At present, the main chemical constituents isolated from CR are volatile oil, flavonoids and terpenes. Modern pharmacological studies have shown that CR has a wide range of pharmacological activities, including antidepressant, hypoglycemic, antioxidant, anti-inflammatory, antipyretic and analgesic effects. In this paper, the botany, traditional application, phytochemistry, pharmacological effects, processing and other aspects of CR are reviewed. At the same time, the shortcomings of current research of CR are discussed in depth, and the possible solutions are put forward in order to find a breakthrough point for future research of CR.

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“…Rhizoma Cyperi is known for its ability to clear the liver, relieve depression, regulate qi, and relieve menstrual pain. Modern studies have shown that the chemical components of Rhizoma Cyperi mainly include terpenes, flavonoids, alkaloids, sugars, sterols, and other components, which have pharmacological effects such as antitumor, antidepression, anti-inflammatory, antibacterial, antioxidation, and hypoglycemic effects [ 58 ]. Volatile oils, including α-vanvanone, vanvanolone, etc., are the main components of Rhizoma Cyperi, with a mass fraction of 0.65–1.4% [ 59 , 60 ].…”

Exploration of the mechanisms of Cyperi Rhizoma in the treatment of endometriosis through GEO datasets, network pharmacology, and molecular docking studies

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“…The conventional approach to treating endometriosis is surgical removal of the lesions and hormonal suppression, but these treatments are often associated with side effects and a high rate of recurrence [2]. Against this backdrop, complementary and alternative medicine (CAM) has recently gained popularity due to its low side effects and high e cacy [3].Cyperi Rhizoma (CR), the dried rhizome of Cyperus rotundus L. of the plant family Cyperaceae, has a long history of clinical use and is referred to as the 'holy medicine' in gynaecology [4]. Pharmacological studies have shown that CR has multiple properties, including antioxidant, anti-in ammatory, antidepressant, antipyretic, analgesic, antitumour, hypoglycaemic and antibacterial effects.…”